The impact of heparin and direct thrombin inhibitors on cell-penetrating polymer siRNA transfection

Zhang MM, Bahal R, Rasmussen TP, Manautou JE, Zhong XB. The growth of siRNA-based therapeutics: Updated clinical studies. Biochem Pharmacol. 2021;189:114432.

Article  CAS  PubMed  Google Scholar 

Saw PE, Song EW. siRNA therapeutics: a clinical reality. Sci China Life Sci. 2020;63:485–500.

Article  CAS  PubMed  Google Scholar 

Jaiprasart P, Yeung BZ, Lu Z, Wientjes MG, Cui M, Hsieh CM, et al. Quantitative contributions of processes by which polyanion drugs reduce intracellular bioavailability and transfection efficiency of cationic siRNA lipoplex. J Control Release. 2018;270:101–13.

Article  CAS  PubMed  Google Scholar 

Nabzdyk CS, Chun M, Pradhan Nabzdyk L, Yoshida S, LoGerfo FW. Differential susceptibility of human primary aortic and coronary artery vascular cells to RNA interference. Biochem Biophys Res Commun. 2012;425:261–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nabzdyk CS, Chun M, Pradhan L, Logerfo FW. High throughput RNAi assay optimization using adherent cell cytometry. J Transl Med. 2011;9:48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nabzdyk CS, Chun MC, Oliver-Allen HS, Pathan SG, Phaneuf MD, You JO, et al. Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts. Biomaterials. 2014;35:3071–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andersen ND, Monahan TS, Malek JY, Jain M, Daniel S, Caron LD, et al. Comparison of gene silencing in human vascular cells using small interfering RNAs. J Am Coll Surg. 2007;204:399–408.

Article  PubMed  Google Scholar 

Cinquin B, Lopes F. Structure and fluorescence intensity measurements in biofilms. Methods Mol Biol. 2019;2040:117–33.

Article  CAS  PubMed  Google Scholar 

Ivandic B, Zorn M. Monitoring of the anticoagulants argatroban and lepirudin: a comparison of laboratory methods. Clin Appl Thromb Hemost. 2011;17:549–55.

Article  CAS  PubMed  Google Scholar 

Beiderlinden M, Werner P, Bahlmann A, Kemper J, Brezina T, Schafer M, et al. Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial. BMC Anesthesiol. 2018;18:18.

Article  PubMed  PubMed Central  Google Scholar 

Veale JJ, McCarthy HM, Palmer G, Dyke CM. Use of bivalirudin as an anticoagulant during cardiopulmonary bypass. J Extra Corpor Technol. 2005;37:296–302.

Article  PubMed  PubMed Central  Google Scholar 

Despotis GJ, Summerfield AL, Joist JH, Goodnough LT, Santoro SA, Spitznagel E, et al. Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations. J Thorac Cardiovasc Surg. 1994;108:1076–82.

Article  CAS  PubMed  Google Scholar 

Raymond PD, Ray MJ, Callen SN, Marsh NA. Heparin monitoring during cardiac surgery. Part 1: Validation of whole-blood heparin concentration and activated clotting time. Perfusion. 2003;18:269–76.

Article  CAS  PubMed  Google Scholar 

Aleman LM, Doench J, Sharp PA. Comparison of siRNA-induced off-target RNA and protein effects. RNA. 2007;13:385–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han H. RNA interference to knock down gene expression. Methods Mol Biol. 2018;1706:293–302.

Article  CAS  PubMed  Google Scholar 

Ruigrok MJR, Xian JL, Frijlink HW, Melgert BN, Hinrichs WLJ, Olinga P. siRNA-mediated protein knockdown in precision-cut lung slices. Eur J Pharm Biopharm. 2018;133:339–48.

Article  CAS  PubMed  Google Scholar 

Koren MJ, Moriarty PM, Baum SJ, Neutel J, Hernandez-Illas M, Weintraub HS, et al. Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a). Nat Med. 2022;28:96–103.

Article  CAS  PubMed  Google Scholar 

Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V, et al. A highly durable RNAi therapeutic inhibitor of PCSK9. N Engl J Med. 2017;376:41–51.

Article  CAS  PubMed  Google Scholar 

Bodewes TC, Johnson JM, Auster M, Huynh C, Muralidharan S, Contreras M, et al. Intraluminal delivery of thrombospondin-2 small interfering RNA inhibits the vascular response to injury in a rat carotid balloon angioplasty model. FASEB J. 2017;31:109–19.

Article  CAS  PubMed  Google Scholar 

Singh J, Kassis N, Ahuja KR, Sheth C, Verma BR, Saxena S, et al. Percutaneous coronary intervention outcomes based on decision-making capacity. J Am Heart Assoc. 2021;10:e020609.

Article  PubMed  PubMed Central  Google Scholar 

Collins D, Goldberg S. Care of the post-CABG patient. Cardiol Rev. 2020;28:26–35.

Article  PubMed  Google Scholar 

Goodney PP, Beck AW, Nagle J, Welch HG, Zwolak RM. National trends in lower extremity bypass surgery, endovascular interventions, and major amputations. J Vasc Surg. 2009;50:54–60.

Article  PubMed  Google Scholar 

Conners MS 3rd, Money SR. The new heparins. Ochsner J. 2002;4:41–7.

PubMed  PubMed Central  Google Scholar 

McKeage K, Plosker GL. Argatroban. Drugs. 2001;61:515–22.

Article  CAS  PubMed  Google Scholar 

Warkentin TE, Koster A. Bivalirudin: a review. Expert Opin Pharmacother. 2005;6:1349–71.

Article  CAS  PubMed  Google Scholar 

Jeske WP, Fareed J, Hoppensteadt DA, Lewis B, Walenga JM. Pharmacology of argatroban. Expert Rev Hematol. 2010;3:527–39.

Article  CAS  PubMed  Google Scholar 

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, et al. PubChem 2023 update. Nucleic Acids Res. 2023;51:D1373–D80.

Article  PubMed  Google Scholar 

Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61:77–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hvas AM, Favaloro EJ, Hellfritzsch M. Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment. Expert Rev Hematol. 2021;14:335–46.

Article  CAS  PubMed  Google Scholar 

Lewis BE, Wallis DE, Leya F, Hursting MJ, Kelton JG, Argatroban I. Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. Arch Intern Med. 2003;163:1849–56.

Article  CAS  PubMed  Google Scholar 

Chew DP. Bivalirudin, a bivalent, thrombin specific anticoagulant as an alternative to heparin in interventional procedures as an alternative to heparin in interventional procedures. Hamostaseologie. 2002;22:60–6.

CAS  PubMed 

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