Algorithm to guide clinical evaluation and management of corticobasal syndrome. Though a clinical exam only is not enough to determine underlying pathology, some key features were indicated here. Currently, available biomarkers in clinical practice are detailed, though this is a rapidly evolving field, and plasma biomarkers may find their place in this table very soon. AD: Alzheimer’s Disease. CJD: Creutzfeldt-Jakob Disease. PSP: progressive Supranuclear Palsy. CBD: Corticobasal Degeneration. LBD: Lewy Body Disease. FTLD: Frontotemporal Lobar Degeneration. PCA: Posterior Cortical Atrophy. nfPPA: nonfluent Primary Progressive Aphasia (PPA). svPPA: Semantic variant PPA. lvPPA: logopenic variant PPA. PSWC: Periodic sharp wave complexes. RBD: REM sleep Behavior Disorder