Saver JL, Jahan R, Levy EI, et al. Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet. 2012;380(9849):1241–9.

Article  PubMed  Google Scholar 

Kidwell CS, Jahan R, Gornbein J, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013;368(10):914–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nogueira RG, Lutsep HL, Gupta R, et al. Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet. 2012;380(9849):1231–40.

Article  PubMed  PubMed Central  Google Scholar 

Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372(24):2296–306.

Article  CAS  PubMed  Google Scholar 

Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372(11):1009–18.

Article  CAS  PubMed  Google Scholar 

Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372(11):1019–30.

Article  CAS  PubMed  Google Scholar 

Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372(24):2285–95.

Article  CAS  PubMed  Google Scholar 

Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372(1):11–20.

Article  PubMed  Google Scholar 

Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387(10029):1723–31.

Article  PubMed  Google Scholar 

Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378(1):11–21.

Article  PubMed  Google Scholar 

Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378(8):708–18.

Article  PubMed  PubMed Central  Google Scholar 

Yoshimura S, Sakai N, Yamagami H, et al. Endovascular therapy for acute stroke with a large ischemic region. N Engl J Med. 2022;386(14):1303–13. First pivotal trial demonstrating a benefit of mechanical thrombectomy in strokes with large ischemic core.

Article  PubMed  Google Scholar 

Sarraj A, Hassan AE, Abraham MG, et al. Trial of Endovascular Thrombectomy for Large Ischemic Strokes. N Engl J Med. 2023;388(14):1259–71. This is a recent pivotal trials conducted to demonstrate the effect of thrombectomy on large core acute ischemic stroke.

Article  PubMed  Google Scholar 

Huo X, Ma G, Tong X, et al. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct. N Engl J Med. 2023;388(14):1272–83. This is a recent pivotal trials conducted to demonstrate the effect of thrombectomy on large core acute ischemic stroke.

Article  CAS  PubMed  Google Scholar 

Bendszus M, Fiehler J, Subtil F, et al. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial. Lancet. 2023;402(10414):1753–63 This is a recent pivotal trials conducted to demonstrate the effect of thrombectomy on large core acute ischemic stroke.

Article  PubMed  Google Scholar 

Zaidat OO, Kasab SA, Sheth S, et al. TESLA trial: rationale, protocol, and design. Stroke Vasc Interv Neurol. 2023;3(4):e000787. This is a recent pivotal trials conducted to demonstrate the effect of thrombectomy on large core acute ischemic stroke.

Google Scholar 

Costalat V, Lapergue B, Albucher JF, et al. Evaluation of acute mechanical revascularization in large stroke (ASPECTS ⩽5) and large vessel occlusion within 7 h of last-seen-well: The LASTE multicenter, randomized, clinical trial protocol. Int J Stroke. 2024;19(1):114–9. This is a recent pivotal trials conducted to demonstrate the effect of thrombectomy on large core acute ischemic stroke.

Article  PubMed  Google Scholar 

Langezaal LCM, van der Hoeven E, Mont’Alverne FJA, et al. Endovascular therapy for stroke due to basilar-artery occlusion. N Engl J Med. 2021;384(20):1910–20.

Article  PubMed  Google Scholar 

Liu X, Dai Q, Ye R, et al. Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol. 2020;19(2):115–22.

Article  PubMed  Google Scholar 

Nguyen TN, Strbian D. Endovascular therapy for stroke due to basilar artery occlusion: a BASIC challenge at BEST. Stroke. 2021;52(10):3410–3.

Article  PubMed  Google Scholar 

Tao C, Nogueira RG, Zhu Y, et al. Trial of endovascular treatment of acute basilar-artery occlusion. N Engl J Med. 2022;387(15):1361–72. First trial to demonstrate an improvement in outcomes with basilar artery thrombectomy.

Article  PubMed  Google Scholar 

Jovin TG, Li C, Wu L, et al. Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med. 2022;387(15):1373–84. Pivotal trial demonstrating an improvement in functional outcomes and mortality in thrombectomy for basilar artery occlusion in the 6–24 hour window.

Article  PubMed  Google Scholar 

Malik A, Drumm B, D’Anna L, et al. Mechanical thrombectomy in acute basilar artery stroke: a systematic review and meta-analysis of randomized controlled trials. BMC Neurol. 2022;22(1):415.

Article  PubMed  PubMed Central  Google Scholar 

Romano JG, Smith EE, Liang L, et al. Outcomes in mild acute ischemic stroke treated with intravenous thrombolysis: a retrospective analysis of the Get With the Guidelines-Stroke registry. JAMA Neurol. 2015;72(4):423–31.

Article  PubMed  Google Scholar 

Mazya MV, Cooray C, Lees KR, et al. Minor stroke due to large artery occlusion. When is intravenous thrombolysis not enough? Results from the SITS International Stroke Thrombolysis Register. Eur Stroke J. 2018;3(1):29–38.

Article  PubMed  Google Scholar 

Kim JT, Park MS, Chang J, et al. Proximal arterial occlusion in acute ischemic stroke with low NIHSS scores should not be considered as mild stroke. PLoS ONE. 2013;8(8):e70996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajajee V, Kidwell C, Starkman S, et al. Early MRI and outcomes of untreated patients with mild or improving ischemic stroke. Neurology. 2006;67(6):980–4.

Article  CAS  PubMed  Google Scholar 

Saleem Y, Nogueira RG, Rodrigues GM, et al. Acute neurological deterioration in large vessel occlusions and mild symptoms managed medically. Stroke. 2020;51(5):1428–34.

Article  PubMed  Google Scholar 

Lin CH, Saver JL, Ovbiagele B, et al. Effects of endovascular therapy for mild stroke due to proximal or M2 occlusions: meta-analysis. J Neurointerv Surg. 2023;15(4):350–4.

Article  PubMed  Google Scholar 

Endovascular therapy for low NIHSS ischemic strokes (ENDOLOW). ClinicalTrials.gov identifier: NCT04167527. Updated May 8, 2024. https://clinicaltrials.gov/study/NCT04167527. Accessed 25 Jun 2024.

Minor stroke therapy evaluation (MOSTE). ClinicalTrials.gov identifier: NCT03796468. Updated August 31, 2023. https://clinicaltrials.gov/study/NCT03796468. Accessed 25 Jun 2024.

Ospel JM, Goyal M. A review of endovascular treatment for medium vessel occlusion stroke. J Neurointerv Surg. 2021;13(7):623–30.

Article  PubMed  Google Scholar 

Saver JL, Chapot R, Agid R, et al. Thrombectomy for distal, medium vessel occlusions: a consensus statement on present knowledge and promising directions. Stroke. 2020;51(9):2872–84.

Article  PubMed  Google Scholar 

Barchetti G, Cagnazzo F, Raz E, et al. Mechanical thrombectomy of distal occlusions using a direct aspiration first pass technique compared with new generation of mini-0.017 microcatheter compatible-stent retrievers: a meta-analysis. World Neurosurg. 2020;134:111–9.

Article  PubMed  Google Scholar 

Waqas M, Kuo CC, Dossani RH, et al. Mechanical thrombectomy versus intravenous thrombolysis for distal large-vessel occlusion: a systematic review and meta-analysis of observational studies. Neurosurg Focus. 2021;51(1):E5.

Article  PubMed