Gut colonization with multidrug resistant organisms in the intensive care unit: a systematic review and meta-analysis

Russell DL, Flood A, Zaroda TE, Acosta C, Riley MMS, Busuttil RW, et al. Outcomes of colonization with MRSA and VRE Among liver transplant candidates and recipients. Am J Transpl. 2008;8(8):1737–43.

Article  CAS  Google Scholar 

Freedberg DE, Zhou MJ, Cohen ME, Annavajhala MK, Khan S, Moscoso DI, et al. Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection. Intensive Care Med. 2018;44(8):1203–11.

Article  PubMed  PubMed Central  Google Scholar 

Willems RPJ, van Dijk K, Vehreschild MJGT, Biehl LM, Ket JCF, Remmelzwaal S, et al. Incidence of infection with multidrug-resistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis. Lancet Infect Dis. 2023;23(6):719–31.

Article  CAS  PubMed  Google Scholar 

Campos-Madueno EI, Moradi M, Eddoubaji Y, Shahi F, Moradi S, Bernasconi OJ, et al. Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers. Eur J Clin Microbiol Infect Dis. 2023;42(3):229–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prado V, Hernández-Tejero M, Mücke MM, Marco F, Gu W, Amoros A, et al. Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis Graphical abstract Rectal colonization by multidrug-resistant organism Predominant colonizing strain. J Hepatol. 2022;76:1079–89.

Article  PubMed  Google Scholar 

Prematunge C, MacDougall C, Johnstone J, Adomako K, Lam F, Robertson J, et al. VRE and VSE Bacteremia Outcomes in the Era of Effective VRE Therapy: A Systematic Review and Meta-analysis. Infect Control Hosp Epidemiol. 2016;37(1):26–35.

Article  PubMed  Google Scholar 

Alevizakos M, Gaitanidis A, Nasioudis D, Tori K, Flokas ME, Mylonakis E. colonization with vancomycin-resistant enterococci and risk for bloodstream infection among patients with malignancy: a systematic review and meta-analysis. Open Forum Infect Dis. 2017;4(1):ofw246.

D’Agata EMC, Geffert SF, McTavish R, Wilson F, Cameron C. Acquisition of antimicrobial-resistant bacteria in the absence of antimicrobial exposure: a systematic review and meta-analysis. Infect Control Hosp Epidemiol. 2019;40(10):1128–34.

Article  PubMed  Google Scholar 

Detsis M, Karanika S, Mylonakis E. ICU acquisition rate, risk factors, and clinical significance of digestive tract colonization with extended-spectrum beta-lactamase–producing enterobacteriaceae. Crit Care Med. 2017;45(4):705–14.

Article  PubMed  Google Scholar 

Ziakas PD, Thapa R, Rice LB, Mylonakis E. Trends and significance of VRE colonization in the ICU: a meta-analysis of published studies. PLOS ONE. 2013;8(9):e75658-e.

Tesfa T, Mitiku H, Edae M, Assefa N. Prevalence and incidence of carbapenem-resistant K. pneumoniae colonization: systematic review and meta-analysis. Systc Rev. 2022;11(1).

Arzilli G, Scardina G, Casigliani V, Petri D, Porretta A, Moi M, et al. Screening for antimicrobial-resistant Gram-negative bacteria in hospitalised patients, and risk of progression from colonisation to infection: systematic review. J Infect. 2022;84(2):119–30.

Article  CAS  PubMed  Google Scholar 

Ferrer R, Soriano A, Cantón R, Del Pozo JL, García-Vidal C, Garnacho-Montero J, et al. A systematic literature review and expert consensus on risk factors associated to infection progression in adult patients with respiratory tract or rectal colonisation by carbapenem-resistant Gram-negative bacteria. Rev Esp Quimioter. 2022;35(5):455–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choy A, Freedberg DE. Impact of microbiome-based interventions on gastrointestinal pathogen colonization in the intensive care unit. Ther Adv Gastroenterol. 2020;13:175628482093944.

Article  Google Scholar 

Saha S, Tariq R, Tosh PK, Pardi DS, Khanna S. Faecal microbiota transplantation for eradicating carriage of multidrug-resistant organisms: a systematic review. Clin Microbiol Infect. 2019;25(8):958–63.

Article  CAS  PubMed  Google Scholar 

Straub TJ, Lombardo M-J, Bryant JA, Diao L, Lodise TP, Freedberg DE, et al. Impact of a purified microbiome therapeutic on abundance of antimicrobial resistance genes in patients with recurrent clostridioides difficile infection. Clin Infect Dis. 2024;78(4):833–41.

Article  PubMed  Google Scholar 

Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc. 2015;13(3):147–53.

Article  PubMed  Google Scholar 

Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–27.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, The PRISMA, et al. statement: an updated guideline for reporting systematic reviews. BMJ. 2020;2021:n71.

Google Scholar 

Covidence systematic review software: Veritas Health Innovation; 2023 [updated March 8, 2023]. Available from: www.covidence.org.

Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

National Heart, Lung, and Blood Institute. Quality assessment tool for observational cohort and cross-sectional studies. 2021. Available from: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools.

Grohs P, Podglajen I, Guerot E, Bellenfant F, Caumont-Prim A, Kac G, et al. Assessment of five screening strategies for optimal detection of carriers of third-generation cephalosporin-resistant Enterobacteriaceae in intensive care units using daily sampling. Clin Microbiol Infect. 2014;20(11):O879–86.

Article  CAS  PubMed  Google Scholar 

Karanika S, Karantanos T, Arvanitis M, Grigoras C, Mylonakis E. Fecal colonization with extended-spectrum beta-lactamase-producing enterobacteriaceae and risk factors among healthy individuals: a systematic review and metaanalysis. Clin Infect Dis. 2016;63(3):310–8.

Article  PubMed  Google Scholar 

Jolivet S, Lolom I, Bailly S, Bouadma L, Lortat-Jacob B, Montravers P, et al. Impact of colonization pressure on acquisition of extended-spectrum β-lactamase-producing Enterobacterales and meticillin-resistant Staphylococcus aureus in two intensive care units: a 19-year retrospective surveillance. J Hosp Infect. 2020;105(1):10–6.

Article  CAS  PubMed  Google Scholar 

Lagier JC, Armougom F, Million M, Hugon P, Pagnier I, Robert C, et al. Microbial culturomics: paradigm shift in the human gut microbiome study. Clin Microbiol Infect. 2012;18(12):1185–93.

Article  CAS  PubMed  Google Scholar 

Kollef MH, Shorr AF, Bassetti M, Timsit J-F, Micek ST, Michelson AP, et al. Timing of antibiotic therapy in the ICU. Crit Care. 2021;25(1).

Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–96.

Article  PubMed  Google Scholar 

Massart N, Camus C, Benezit F, Moriconi M, Fillatre P, Le Tulzo Y. Incidence and risk factors for acquired colonization and infection due to extended-spectrum beta-lactamase-producing Gram-negative bacilli: a retrospective analysis in three ICUs with low multidrug resistance rate. Eur J Clin Microbiol Infect Dis. 2020;39(5):889–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teerawattanapong N, Kengkla K, Dilokthornsakul P, Saokaew S, Apisarnthanarak A, Chaiyakunapruk N. Prevention and control of multidrug-resistant gram-negative bacteria in adult intensive care units: a systematic review and network meta-analysis. Clin Infect Dis. 2017;64:S51–60.

Article  CAS  PubMed  Google Scholar 

Radhakrishnan ST, Gallagher KI, Mullish BH, Serrano-Contreras JI, Alexander JL, Miguens Blanco J, et al. Rectal swabs as a viable alternative to faecal sampling for the analysis of gut microbiota functionality and composition. Sci Rep. 2023;13(1).

Ajao AO, Johnson JK, Harris AD, Zhan M, McGregor JC, Thom KA, et al. Risk of acquiring extended-spectrum β-lactamase-producing Klebsiella species and Escherichia coli from prior room occupants in the intensive care unit. Infect Control Hosp Epidemiol. 2013;34(5):453–8.

Article  PubMed  PubMed Central  Google Scholar 

Alves M, Lemire A, Decré D, Margetis D, Bigé N, Pichereau C, et al. Extended-spectrum beta-lactamase–producing enterobacteriaceae in the intensive care unit: acquisition does not mean cross-transmission. BMC Infect Dis. 2016;16:147.

Article  PubMed  PubMed Central  Google Scholar 

Boutrot M, Azougagh K, Guinard J, Boulain T. Antibiotics with activity against intestinal anaerobes and the hazard of acquired colonization with ceftriaxone-resistant Gram-negative pathogens in ICU patients: a propensity score-based analysis. J Antimicrob Chemother. 2019;74(10):3095–103.

Article  CAS  PubMed  Google Scholar 

Gómez-Zorrilla S, Camoez M, Tubau F, Periche E, Cañizares R, Dominguez MA, et al. Antibiotic pressure is a major risk factor for rectal colonization by multidrug-resistant pseudomonas aeruginosa in critically ill patients. Antimicrob Agents Chemother. 2014;58(10):5863–70.

Article  PubMed  PubMed Central  Google Scholar 

Marchenay P, Blasco G, Navello

留言 (0)

沒有登入
gif