World Health Organization [Internet]. Human papillomavirus vaccines: WHO position paper (2022 update). Available from: https://www.who.int/publications/i/item/who-wer9750-645-672.
zur Hausen, H. Papillomaviruses in the causation of human cancers—a brief historical account. Virology 384, 260–265 (2009).
Article CAS PubMed Google Scholar
zur Hausen, H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2, 342–350 (2002).
Article CAS PubMed Google Scholar
Thomsen, L. T. & Kjær, S. K. Human papillomavirus (HPV) testing for cervical cancer screening in a middle-income country: comment on a large real-world implementation study in China. BMC Med. 19, 165 (2021).
Article PubMed PubMed Central Google Scholar
Lehtinen, M. & Dillner, J. Clinical trials of human papillomavirus vaccines and beyond. Nat. Rev. Clin. Oncol. 10, 400–410 (2013).
Article CAS PubMed Google Scholar
Huh, W. K. et al. Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial. Lancet (Lond., Engl.) 390, 2143–2159 (2017).
Hildesheim, A. et al. Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial. Jama 298, 743–753 (2007).
Article CAS PubMed Google Scholar
Garland, S. M. et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N. Engl. J. Med. 356, 1928–1943 (2007).
Article CAS PubMed Google Scholar
Tsu, V. D., LaMontagne, D. S., Atuhebwe, P., Bloem, P. N. & Ndiaye, C. National implementation of HPV vaccination programs in low-resource countries: Lessons, challenges, and future prospects. Prevent. Med. 144, 106335 (2021).
Lin, K., Doolan, K., Hung, C. F. & Wu, T. C. Perspectives for preventive and therapeutic HPV vaccines. J. Formos. Med. Assoc. Taiwan yi zhi 109, 4–24 (2010).
Article CAS PubMed Google Scholar
Cordeiro, M. N. et al. Current research into novel therapeutic vaccines against cervical cancer. 18, 365–376, https://doi.org/10.1080/14737140.2018.1445527 (2018).
Roden, R. B., Ling, M. & Wu, T. C. Vaccination to prevent and treat cervical cancer. Hum. Pathol. 35, 971–982 (2004).
Smalley Rumfield, C., Roller, N. & Pellom, S. T. Therapeutic vaccines for HPV-associated malignancies. 9, 167–200, https://doi.org/10.2147/itt.s273327 (2020).
Huber, B., Wang, J. W., Roden, R. B. S. & Kirnbauer, R. RG1-VLP and other L2-based, broad-spectrum HPV vaccine candidates. J. Clin. Med. 10, https://doi.org/10.3390/jcm10051044 (2021).
Áyen, Á., Jiménez Martínez, Y. & Boulaiz, H. Targeted gene delivery therapies for cervical cancer. 12, https://doi.org/10.3390/cancers12051301 (2020).
Muller, M. et al. Chimeric papillomavirus-like particles. Virology 234, 93–111 (1997).
Article CAS PubMed Google Scholar
Greenstone, H. L. et al. Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model. Proc. Natl Acad. Sci. USA 95, 1800–1805 (1998).
Article CAS PubMed PubMed Central Google Scholar
van der Burg, S. H. et al. Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens. Vaccine 19, 3652–3660 (2001).
Kim, D. et al. Generation and characterization of a preventive and therapeutic HPV DNA vaccine. Vaccine 26, 351–360 (2008).
Article CAS PubMed Google Scholar
Kirnbauer, R. et al. Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J. Virol. 67, 6929–6936 (1993).
Article CAS PubMed PubMed Central Google Scholar
Xu, Y. F. et al. Encapsidating artificial human papillomavirus-16 mE7 protein in human papillomavirus-6b L1/L2 virus like particles. Chin. Med. J. 120, 503–508 (2007).
Article CAS PubMed Google Scholar
Davidson, E. J. et al. Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). Vaccine 22, 2722–2729 (2004).
Article CAS PubMed Google Scholar
Peng, S. et al. Control of HPV-associated tumors by innovative therapeutic HPV DNA vaccine in the absence of CD4+ T cells. Cell Biosci. 4, 11 (2014).
Article PubMed PubMed Central Google Scholar
Canali, E. et al. A high-performance thioredoxin-based scaffold for peptide immunogen construction: proof-of-concept testing with a human papillomavirus epitope. Sci. Rep. 4, 4729 (2014).
Article PubMed PubMed Central Google Scholar
Seitz, H. et al. A three component mix of thioredoxin-L2 antigens elicits broadly neutralizing responses against oncogenic human papillomaviruses. Vaccine 32, 2610–2617 (2014).
Article CAS PubMed Google Scholar
Seitz, H. et al. Robust in vitro and in vivo neutralization against multiple high-risk HPV types induced by a thermostable thioredoxin-L2 vaccine. Cancer Prev. Res. (Phila) 8, 932–941 (2015).
Article CAS PubMed Google Scholar
Del Campo, J. & Pizzorno, A. OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes. 4, 4, https://doi.org/10.1038/s41541-019-0098-4 (2019).
Ogun, S. A., Dumon-Seignovert, L., Marchand, J. B., Holder, A. A. & Hill, F. The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria. Infect. Immun. 76, 3817–3823 (2008).
Article CAS PubMed PubMed Central Google Scholar
Minhinnick, A. et al. A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults. Vaccine 34, 1412–1421 (2016).
Article CAS PubMed PubMed Central Google Scholar
Li, Y. et al. Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology. Sci. Rep. 6, 18848 (2016).
Article CAS PubMed PubMed Central Google Scholar
Spencer, A. J. et al. Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates. PloS One 7, e33555 (2012).
Article CAS PubMed PubMed Central Google Scholar
Zhao, X., Yang, F., Mariz, F. & Osen, W. Combined prophylactic and therapeutic immune responses against human papillomaviruses induced by a thioredoxin-based L2-E7 nanoparticle vaccine. 16, e1008827, https://doi.org/10.1371/journal.ppat.1008827 (2020).
OSIVAX [Internet] Available from: https://osivax.com/technology/.
Spagnoli, G. et al. Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles. Sci. Rep. 7, 18000 (2017).
Article PubMed PubMed Central Google Scholar
Pouyanfard, S. et al. Minor capsid protein L2 polytope induces broad protection against oncogenic and mucosal human papillomaviruses. J. Virol. 92, https://doi.org/10.1128/jvi.01930-17 (2018).
Jin, L. et al. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J. Immunol. (Baltim., Md.: 1950) 187, 2595–2601 (2011).
Burdette, D. L. et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478, 515–518 (2011).
留言 (0)