Mowat C, Cole A, Windsor A, Ahmad T, Arnott I, Driscoll R, et al. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60:571–607. https://doi.org/10.1136/gut.2010.224154
Chatu S, Subramanian V, Saxena S, Pollok RC. The role of thiopurines in reducing the need for surgical resection in Crohn’s disease: a systematic review and meta-analysis. Am J Gastroenterol. 2012;107:23–34. https://doi.org/10.1038/ajg.2011.401
Peyrin-Biroulet L, Khosrotehrani K, Carrat F, Bouvier AM, Chevaux JB, Simon T, et al. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn’s disease: a meta-analysis. Am J Gastroenterol. 2009;104:2089–96. https://doi.org/10.1038/ajg.2009.301
Article CAS PubMed Google Scholar
Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, et al. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010;362:1383–95. https://doi.org/10.1056/NEJMoa0904492
Article CAS PubMed Google Scholar
Chaparro M, Panés J, García V, Mendoza JL, Bermejo F, López San Román A, et al. Safety of thiopurine therapy in inflammatory bowel disease: Long-term follow-up study of 3931 patients. Inflamm Bowel Dis. 2013;19:1404–10. https://doi.org/10.1097/MIB.0b013e318281f28f
Schwab M, Schäffeler E, Marx C, Fischer C, Lang T, Behrens C, et al. Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism. Pharmacogenetics. 2002;12:429–36. https://doi.org/10.1097/00008571-200208000-00003
Article CAS PubMed Google Scholar
Chande N, Laidlaw M, McDonald JW, Macdonald JK. Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2013;10:CD000545 https://doi.org/10.1002/14651858.CD000545.pub5
Friedman AB, Sparrow MP, Gibson PR. The role of thiopurine metabolites in inflammatory bowel disease and rheumatological disorders. Int J Rheum Dis. 2014;17:132–41. https://doi.org/10.1111/1756-185X.12204
Article CAS PubMed Google Scholar
Relling MV, Hancock ML, Rivera GK, Sandlund JT, Ribeiro RC, Krynetski EY, et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst. 1999;91:2001–8.
Article CAS PubMed Google Scholar
Chouchana L, Narjoz C, Beaune P, Loriot MA, Roblin X. Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2012;35:15–36. https://doi.org/10.1111/j.1365-2036.2011.04905.x
Article CAS PubMed Google Scholar
Higgs JE, Payne K, Roberts C, Newman WG. Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications? Pharmacogenomics. 2010;11:177–88. https://doi.org/10.2217/pgs.09.155
Article CAS PubMed Google Scholar
Gearry RB, Barclay ML, Burt MJ, Collett JA, Chapman BA, Roberts RL, et al. Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2003;18:395–400. https://doi.org/10.1046/j.1365-2036.2003.01690.x
Article CAS PubMed Google Scholar
Colombel JF, Ferrari N, Debuysère H, Marteau P, Gendre JP, Bonaz B, et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn’s disease and severe myelosuppression during azathioprine therapy. Gastroenterology. 2000;118:1025–30. https://doi.org/10.1016/S0016-5085(00)70354-4
Article CAS PubMed Google Scholar
Ansari A, Arenas M, Greenfield SM, Morris D, Lindsay J, Gilshenan K, et al. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment Pharmacol Ther. 2002;16:1743–50. https://doi.org/10.1046/j.1365-2036.2002.01353.x
Article CAS PubMed Google Scholar
Sumi S, Marinaki AM, Arenas M, Fairbanks L, Shobowale-Bakre EM, Rees DC, et al. Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. Hum Genet. 2002;111:360–7. https://doi.org/10.1007/s00439-002-0798-z
Article CAS PubMed Google Scholar
Marinaki AM, Duley JA, Arenas M, Sumi S, Lewis CM, Shobowale-Bakre M, et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics. 2004;14:181–7. https://doi.org/10.1097/00008571-200403000-00006
Article CAS PubMed Google Scholar
Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, et al. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat Genet. 2016;48:367–73. https://doi.org/10.1038/ng.3508
Article CAS PubMed PubMed Central Google Scholar
Yang JJ, Whirl-Carrillo M, Scott SA, Turner AJ, Schwab M, Tanaka Y, et al. Pharmacogene variation consortium gene introduction: NUDT15. Clin Pharmacol Ther. 2019;105:1091–4. https://doi.org/10.1002/cpt.1411
Maaser C, Sturm A, Vavricka SR, Kucharzik T, Fiorino G, Annese V, et al. ECCO-ESGAR guideline for diagnostic assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis. 2019;13:144–64. https://doi.org/10.1093/ecco-jcc/jjy113
Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19:5–36.
Harvey RF, Bradshaw JM. A simple index of Crohn’s disease activity. Lancet. 1980;1:514.
Article CAS PubMed Google Scholar
Campbell S, Kingstone K, Ghosh S. Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine. Aliment Pharmacol Ther. 2002;16:389–98. https://doi.org/10.1046/j.1365-2036.2002.01177.x
Article CAS PubMed Google Scholar
Zelinkova Z, Derijks LJ, Stokkers PC, Vogels EW, van Kampen AH, Curvers WL, et al. Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression. Clin Gastroenterol Hepatol. 2006;4:44–49. https://doi.org/10.1016/j.cgh.2005.10.019
Article CAS PubMed Google Scholar
Dewit O, Moreels T, Baert F, Peeters H, Reenaers C, de Vos M, et al. Limitations of extensive TPMT genotyping in the management of azathioprine-induced myelosuppression in IBD patients. Clin Biochem. 2011;44:1062–6. https://doi.org/10.1016/j.clinbiochem.2011.06.079
Article CAS PubMed Google Scholar
Ansari A, Arenas M, Greenfield SM, Morris D, Lindsay J, Gilshenan K, et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther. 2008;28:973–83. https://doi.org/10.1111/j.1365-2036.2008.03788.x
Article CAS PubMed Google Scholar
Hindorf U, Lindqvist M, Peterson C, Söderkvist P, Ström M, Hjortswang H, et al. Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut. 2006;55:1423–31. https://doi.org/10.1136/gut.2005.074930
Article CAS PubMed PubMed Central Google Scholar
Van Dieren JM, van Vuuren AJ, Kusters JG, Nieuwenhuis EE, Kuipers EJ, van der Woude CJ. ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients. Gut. 2005;54:1664.
PubMed PubMed Central Google Scholar
Gutiérrez-Valencia M, Leache L, Saiz LC, Beloqui JJ, Barajas M, Vicuña M, et al. Role of pharmacogenomics in the efficacy and safety of thiopurines in inflammatory bowel disease: a systematic review and meta-analysis. J Clin Gastroenterol. 2023;57:671–85.
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