Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 295(18):2164–2167

Article  CAS  PubMed  Google Scholar 

McLeod DSA, Zhang L, Durante C, Cooper DS (2019) Contemporary debates in adult papillary thyroid cancer management. Endocr Rev 40(6):1481–1499

Article  PubMed  Google Scholar 

Network CGAR (2014) Integrated genomic characterization of papillary thyroid carcinoma. Cell 159(3):676–690

Article  Google Scholar 

Pani F, Caria P, Yasuda Y, Makoto M, Mariotti S, Leenhardt L et al (2022) The immune landscape of papillary thyroid cancer in the context of autoimmune thyroiditis. Cancers 14(17):4287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pizzato M, Li M, Vignat J, Laversanne M, Singh D, La Vecchia C et al (2022) The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020. Lancet Diabetes Endocrinol 10(4):264–272

Article  PubMed  Google Scholar 

Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM et al (2017) American thyroid association guidelines on the management of thyroid nodules and differentiated thyroid cancer task force review and recommendation on the proposed renaming of encapsulated follicular variant papillary thyroid carcinoma without invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Thyroid 27(4):481–483

Article  CAS  PubMed  Google Scholar 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM (2014) Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74(11):2913–2921

Article  CAS  PubMed  Google Scholar 

Cunha LL, Ward LS (2022) Translating the immune microenvironment of thyroid cancer into clinical practice. Endocr Relat Cancer 29(6):R67–R83

Article  CAS  PubMed  Google Scholar 

Menicali E, Guzzetti M, Morelli S, Moretti S, Puxeddu E (2020) Immune landscape of thyroid cancers: new insights. Front Endocrinol (Lausanne) 11:637826

Article  PubMed  Google Scholar 

Febrero B, Ruiz-Manzanera JJ, Ros-Madrid I, Hernández AM, Orenes-Piñero E, Rodríguez JM (2024) Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments. Head Neck 46(6):1486–1499

Article  PubMed  Google Scholar 

Rotondi M, Coperchini F, Latrofa F, Chiovato L (2018) Role of chemokines in thyroid cancer microenvironment: Is CXCL8 the main player? Front Endocrinol (Lausanne) 9:314

Article  PubMed  Google Scholar 

Xie K (2001) Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 12(4):375–391

Article  CAS  PubMed  Google Scholar 

Fang W, Ye L, Shen L, Cai J, Huang F, Wei Q et al (2014) Tumor-associated macrophages promote the metastatic potential of thyroid papillary cancer by releasing CXCL8. Carcinogenesis 35(8):1780–1787

Article  CAS  PubMed  Google Scholar 

Sanmamed MF, Carranza-Rua O, Alfaro C, Oñate C, Martín-Algarra S, Perez G et al (2014) Serum interleukin-8 reflects tumor burden and treatment response across malignancies of multiple tissue origins. Clin Cancer Res 20(22):5697–5707

Article  CAS  PubMed  Google Scholar 

Jurcevic S, Humfrey C, Uddin M, Warrington S, Larsson B, Keen C (2015) The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions. Br J Clin Pharmacol 80(6):1324–1336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uddin M, Betts C, Robinson I, Malmgren A, Humfrey C (2017) The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates. Haematologica 102(2):e65–e68

Article  PubMed  PubMed Central  Google Scholar 

Sody S, Uddin M, Grüneboom A, Görgens A, Giebel B, Gunzer M et al (2019) Distinct spatio-temporal dynamics of tumor-associated neutrophils in small tumor lesions. Front Immunol 10:1419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saintigny P, Massarelli E, Lin S, Ahn YH, Chen Y, Goswami S et al (2013) CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma. Cancer Res 73(2):571–582

Article  CAS  PubMed  Google Scholar 

Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M et al (2008) Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13(1):23–35

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steele CW, Karim SA, Leach JDG, Bailey P, Upstill-Goddard R, Rishi L et al (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell 29(6):832–845

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo F, Long L, Wang J, Wang Y, Liu Y, Wang L et al (2019) Insights on CXC chemokine receptor 2 in breast cancer: an emerging target for oncotherapy. Oncol Lett 18(6):5699–5708

CAS  PubMed  PubMed Central  Google Scholar 

Liotti F, De Pizzol M, Allegretti M, Prevete N, Melillo RM (2017) Multiple anti-tumor effects of Reparixin on thyroid cancer. Oncotarget 8(22):35946–35961

Article  PubMed  PubMed Central  Google Scholar 

Safarulla S, Madan A, Xing F, Chandrasekaran A (2022) CXCR2 mediates distinct neutrophil behavior in brain metastatic breast tumor. Cancers 14(3):515

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coperchini F, Pignatti P, Carbone A, Bongianino R, Di Buduo CA, Leporati P et al (2016) TNF-α increases the membrane expression of the chemokine receptor CCR6 in thyroid tumor cells, but not in normal thyrocytes: potential role in the metastatic spread of thyroid cancer. Tumour Biol 37(4):5569–5575

Article  CAS  PubMed  Google Scholar 

Watz H, Uddin M, Pedersen F, Kirsten A, Goldmann T, Stellmacher F et al (2017) Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma. Pulm Pharmacol Ther 45:121–123

Article  CAS  PubMed  Google Scholar 

Cullberg M, Arfvidsson C, Larsson B, Malmgren A, Mitchell P, Wählby Hamrén U et al (2018) Pharmacokinetics of the oral selective CXCR2 antagonist azd5069: a summary of eight phase I studies in healthy volunteers. Drugs R D 18(2):149–159

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crowley LC, Christensen ME, Waterhouse NJ (2016) Measuring survival of adherent cells with the colony-forming assay. Cold Spring Harb Protoc. https://doi.org/10.1101/pdb.prot087171

Article  PubMed  Google Scholar 

Coperchini F, Croce L, Denegri M, Pignatti P, Agozzino M, Netti GS et al (2020) Adverse effects of in vitro GenX exposure on rat thyroid cell viability, DNA integrity and thyroid-related genes expression. Environ Pollut 264:114778

Article  CAS  PubMed  Google Scholar 

Abbonante V, Gruppi C, Rubel D, Gross O, Moratti R, Balduini A (2013) Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions. J Biol Chem 288(23):16738–16746

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rotondi M, Coperchini F, Pignatti P, Sideri R, Groppelli G, Leporati P et al (2013) Interferon-γ and tumor necrosis factor-α sustain secretion of specific CXC chemokines in human thyrocytes: a first step toward a differentiation between autoimmune and tumor-related inflammation? J Clin Endocrinol Metab 98(1):308–313

Article