Long, H. et al. Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease Study 2019. Arthritis Rheumatol. 74, 1172–1183 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Hootman, J. M., Helmick, C. G., Barbour, K. E., Theis, K. A. & Boring, M. A. Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among US adults, 2015–2040. Arthritis Rheumatol. 68, 1582–1587 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Arden, N. K. et al. Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines. Nat. Rev. Rheumatol. 17, 59–66 (2021).

Article  CAS  PubMed  Google Scholar 

Bijlsma, J. W. J., Berenbaum, F. & Lafeber, F. P. J. G. Osteoarthritis: an update with relevance for clinical practice. Lancet 377, 2115–2126 (2011).

Article  PubMed  Google Scholar 

Sinusas, K. Osteoarthritis: diagnosis and treatment. Am. Fam. Physician 85, 49–56 (2012).

PubMed  Google Scholar 

Maudens, P., Jordan, O. & Allémann, E. Recent advances in intra-articular drug delivery systems for osteoarthritis therapy. Drug. Discov. Today 23, 1761–1775 (2018).

Article  CAS  PubMed  Google Scholar 

Balazs, E. A. & Denlinger, J. L. Viscosupplementation: a new concept in the treatment of osteoarthritis. J. Rheumatol. Suppl. 39, 3–9 (1993).

CAS  PubMed  Google Scholar 

Legré-Boyer, V. Viscosupplementation: techniques, indications, results. Orthop. Traumatol. Surg. Res. 101, S101–S108 (2015).

Article  PubMed  Google Scholar 

Venn, M. & Maroudas, A. Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition. Ann. Rheum. Dis. 36, 121–129 (1977).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sophia Fox, A. J., Bedi, A. & Rodeo, S. A. The basic science of articular cartilage: structure, composition, and function. Sports Health 1, 461–468 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Carballo, C. B., Nakagawa, Y., Sekiya, I. & Rodeo, S. A. Basic science of articular cartilage. Clin. Sports Med. 36, 413–425 (2017).

Article  PubMed  Google Scholar 

Chen, S. S., Falcovitz, Y. H., Schneiderman, R., Maroudas, A. & Sah, R. L. Depth-dependent compressive properties of normal aged human femoral head articular cartilage: relationship to fixed charge density. Osteoarthritis Cartilage 9, 561–569 (2001).

Article  CAS  PubMed  Google Scholar 

Ateshian, G. A. The role of interstitial fluid pressurization in articular cartilage lubrication. J. Biomech. 42, 1163–1176 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Mäkelä, J. T. A., Han, S. K., Herzog, W. & Korhonen, R. K. Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage. J. Biomech. 48, 3369–3376 (2015).

Article  PubMed  Google Scholar 

Park, S., Krishnan, R., Nicoll, S. B. & Ateshian, G. A. Cartilage interstitial fluid load support in unconfined compression. J. Biomech. 36, 1785–1796 (2003).

Article  PubMed  PubMed Central  Google Scholar 

Mansour, J. M. & Mow, V. C. The permeability of articular cartilage under compressive strain and at high pressures. J. Bone Joint Surg. Am. 58, 509–516 (1976).

Article  CAS  PubMed  Google Scholar 

Krishnan, R., Kopacz, M. & Ateshian, G. A. Experimental verification of the role of interstitial fluid pressurization in cartilage lubrication. J. Orthop. Res. 22, 565–570 (2004).

Article  PubMed  PubMed Central  Google Scholar 

McCutchen, C. W. The frictional properties of animal joints. Wear 5, 1–17 (1962).

Article  Google Scholar 

Radin, E. L., Paul, I. L., Swann, D. A. & Schottstaedt, E. S. Lubrication of synovial membrane. Ann. Rheum. Dis. 30, 322 (1971).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ateshian, G. A. & Wang, H. Rolling resistance of articular cartilage due to interstitial fluid flow. Proc. Inst. Mech. Eng. H 211, 419–424 (2016).

Article  Google Scholar 

Walker, P. S., Dowson, D., Longfield, M. D. & Wright, V. Lubrication of human joints. Ann. Rheum. Dis. 28, 194 (1969).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ludwig, T. E., Hunter, M. M. & Schmidt, T. A. Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure. BMC Musculoskelet. Disord. 16, 386 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Bonnevie, E. D., Galesso, D., Secchieri, C., Cohen, I. & Bonassar, L. J. Elastoviscous transitions of articular cartilage reveal a mechanism of synergy between lubricin and hyaluronic acid. PLoS One 10, e0143415 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Greene, G. W. et al. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc. Natl Acad. Sci. USA 108, 5255–5259 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seror, J., Zhu, L., Goldberg, R., Day, A. J. & Klein, J. Supramolecular synergy in the boundary lubrication of synovial joints. Nat. Commun. 2015 61(6), 1–7 (2015).

Google Scholar 

Jahn, S. & Klein, J. Hydration lubrication: the macromolecular domain. Macromolecules 48, 5059–5075 (2015).

Article  CAS  Google Scholar 

Oungoulian, S. R. et al. Articular cartilage wear characterization with a particle sizing and counting analyzer. J. Biomech. Eng. 135, 024501 (2013).

Article  PubMed  Google Scholar 

Workman, J., Thambyah, A. & Broom, N. The influence of early degenerative changes on the vulnerability of articular cartilage to impact-induced injury. Clin. Biomech. 43, 40–49 (2017).

Article  Google Scholar 

Steinmeyer, J., Knue, S., Raiss, R. X. & Pelzer, I. Effects of intermittently applied cyclic loading on proteoglycan metabolism and swelling behaviour of articular cartilage explants. Osteoarthritis Cartilage 7, 155–164 (1999).

Article  CAS  PubMed  Google Scholar 

Hossain, M. J. et al. Anisotropic properties of articular cartilage in an accelerated in vitro wear test. J. Mech. Behav. Biomed. Mater. 109, 103834 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos, S., Emery, N., Neu, C. P. & Pierce, D. M. Propagation of microcracks in collagen networks of cartilage under mechanical loads. Osteoarthritis Cartilage 27, 1392–1402 (2019).

Article  CAS  PubMed  Google Scholar 

McNulty, A. L., Rothfusz, N. E., Leddy, H. A. & Guilak, F. Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. J. Orthop. Res. 31, 1039–1045 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berg, W. B., van den, Loo, F. A., van de, Zwarts, W. A. & Otterness, I. G. Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study. Ann. Rheum. Dis. 47, 855 LP–855863 (1988).

Article  Google Scholar