Update on the pathophysiology and treatment of primary Sjögren syndrome

Mariette, X. & Criswell, L. A. Primary Sjögren’s Syndrome. N. Engl. J. Med. 379, 97 (2018).

PubMed  Google Scholar 

Brito-Zerón, P. et al. Sjögren syndrome. Nat. Rev. Dis. Prim. 2, 16047 (2016).

Article  PubMed  Google Scholar 

Segal, B. M., Pogatchnik, B., Henn, L., Rudser, K. & Sivils, K. M. Pain severity and neuropathic pain symptoms in primary Sjögren’s syndrome: a comparison study of seropositive and seronegative Sjögren’s syndrome patients. Arthritis Care Res. 65, 1291–1298 (2013).

Article  Google Scholar 

Mæland, E., Miyamoto, S. T., Hammenfors, D., Valim, V. & Jonsson, M. V. Understanding fatigue in Sjögren’s syndrome: outcome measures, biomarkers and possible interventions. Front. Immunol. 12, 703079 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Unger, J. et al. The experiences of functioning and health of patients with primary Sjögren’s syndrome: a multicenter qualitative European study. Front. Med. 8, 770422 (2021).

Article  Google Scholar 

Beydon, M. et al. Epidemiology of Sjogren syndrome. Nat. Rev. Rheumatol. 20, 158–169 (2024).

Article  PubMed  Google Scholar 

McCoy, S. S. et al. National Sjögren’s foundation survey: burden of oral and systemic involvement on quality of life. J. Rheumatol. 48, 1029–1036 (2021).

Article  PubMed  Google Scholar 

Tarn, J. et al. Primary Sjögren’s syndrome: longitudinal real-world, observational data on health-related quality of life. J. Intern. Med. 291, 849–855 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Baer, A. N. & Hammitt, K. M. Sjogren’s disease, not syndrome. Arthritis Rheumatol. 73, 1347–1348 (2021).

Article  PubMed  Google Scholar 

Baldini, C., Bartoloni, E. & Bombardieri, M. Highlights of the 15th International Symposium on Sjogren’s Syndrome. Clin. Exp. Rheumatol. 40, 2201–2210 (2022).

PubMed  Google Scholar 

Brito-Zerón, P. et al. Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren’s syndrome. RMD Open. 5, e001064 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Vivino, F. B. et al. Sjogren’s syndrome: an update on disease pathogenesis, clinical manifestations and treatment. Clin. Immunol. 203, 81–121 (2019).

Article  CAS  PubMed  Google Scholar 

Fasano, S. et al. Pathogenesis of primary Sjögren’s syndrome beyond B lymphocytes. Clin. Exp. Rheumatol. 38, 315–323 (2020).

PubMed  Google Scholar 

Fox, R. I., Fox, C. M., Gottenberg, J. E. & Dörner, T. Treatment of Sjögren’s syndrome: current therapy and future directions. Rheumatology 60, 2066–2074 (2021).

Article  CAS  PubMed  Google Scholar 

Retamozo, S., Sisó-Almirall, A., Flores-Chávez, A., Ramos-Casals, M. & Brito-Zerón, P. An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development. Expert. Opin. Pharmacother. 22, 2359–2371 (2021).

Article  CAS  PubMed  Google Scholar 

Ridgewell, D., Thalayasingam, N. & Ng, W. F. Sjögren’s syndrome: shedding light on emerging and key drug targets. Expert. Opin. Ther. Targets 26, 869–882 (2022).

Article  CAS  PubMed  Google Scholar 

Zhan, Q. et al. Pathogenesis and treatment of Sjogren’s syndrome: review and update. Front. Immunol. 14, 1127417 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fox, R. I., Fox, C. M. & McCoy, S. S. Emerging treatment for Sjögren’s disease: a review of recent phase II and III trials. Expert. Opin. Emerg. Drugs 28, 107–120 (2023).

Article  PubMed  Google Scholar 

Bettacchioli, E. et al. Association of combined anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies with increased Sjögren disease severity through interferon pathway activation. Arthritis Rheumatol. 76, 751–762 (2023).

Article  Google Scholar 

James, J. A. et al. Unique Sjögren’s syndrome patient subsets defined by molecular features. Rheumatology 59, 860–868 (2020).

Article  CAS  PubMed  Google Scholar 

Brito-Zerón, P., Retamozo, S. & Ramos-Casals, M. Phenotyping Sjögren’s syndrome: towards a personalised management of the disease. Clin. Exp. Rheumatol. 36, 198–209 (2018).

PubMed  Google Scholar 

Tarn, J. R. et al. Symptom-based stratification of patients with primary Sjögren’s syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials. Lancet Rheumatol. 1, e85–e94 (2019).

Article  PubMed  PubMed Central  Google Scholar 

McCoy, S. S. et al. Symptom-based cluster analysis categorizes Sjögren’s disease subtypes: an international cohort study highlighting disease severity and treatment discordance. Arthritis Rheumatol. 74, 1569–1579 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noaiseh, G. & Baer, A. N. Toward better outcomes in Sjögren’s syndrome: the promise of a stratified medicine approach. Best. Pract. Res. Clin. Rheumatol. 34, 101475 (2020).

Article  PubMed  Google Scholar 

Devauchelle-Pensec, V. et al. French national diagnostic and care protocol for Sjogren’s disease. Rev. Med. Interne 44, 423–457 (2023).

Article  PubMed  Google Scholar 

de Wolff, L., Arends, S., van Nimwegen, J. F. & Bootsma, H. Ten years of the ESSDAI: is it fit for purpose? Clin. Exp. Rheumatol. 38, 283–290 (2020).

PubMed  Google Scholar 

Seror, R. et al. Development and preliminary validation of the Sjögren’s Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren’s syndrome. Ann. Rheum. Dis. 81, 979–989 (2022).

Article  PubMed  Google Scholar 

Brito-Zerón, P. et al. Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren’s syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium. Ann. Rheum. Dis. 76, 1042–1050 (2017).

Article  PubMed  Google Scholar 

Nocturne, G. & Mariette, X. Advances in understanding the pathogenesis of primary Sjögren’s syndrome. Nat. Rev. Rheumatol. 9, 544–556 (2013).

Article  CAS  PubMed  Google Scholar 

Thorlacius, G. E., Björk, A. & Wahren-Herlenius, M. Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies. Nat. Rev. Rheumatol. 19, 288–306 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verstappen, G. M., Pringle, S., Bootsma, H. & Kroese, F. G. M. Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis. Nat. Rev. Rheumatol. 17, 333–348 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chatzis, L., Vlachoyiannopoulos, P. G., Tzioufas, A. G. & Goules, A. V. New frontiers in precision medicine for Sjogren’s syndrome. Expert. Rev. Clin. Immunol. 17, 127–141 (2021).

Article  CAS  PubMed  Google Scholar 

Björk, A., Mofors, J. & Wahren-Herlenius, M. Environmental factors in the pathogenesis of primary Sjögren’s syndrome. J. Intern. Med. 287, 475–492 (2020).

Article  PubMed  Google Scholar 

Lessard, C. J. et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome. Nat. Genet. 45, 1284–1292 (2013).

Article  CAS  PubMed  Google Scholar 

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