Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, et al. The amyloid-β pathway in Alzheimer’s disease. Mol Psychiatry. 2021;26:5481–503.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer’s disease. Neuron. 2014;82:756–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, et al. A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline. Nature. 2012;488:96–9.

Article  CAS  PubMed  Google Scholar 

Benilova I, Gallardo R, Ungureanu AA, Cano VC, Snellinx A, Ramakers M, et al. The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-beta (A beta) aggregation. J Biol Chem. 2014;289:30977–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, et al. The A673T mutation in the amyloid precursor protein reduces the production of beta-amyloid protein from its beta-carboxyl terminal fragment in cells. Acta Neuropathol Commun. 2015;3:ARTN 66.

Article  Google Scholar 

Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990–1000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das P, Chacko AR, Belfort G. Alzheimer’s protective cross-interaction between wild-type and A2T variants alters A beta(42) dimer structure. ACS Chem Neurosci. 2017;8:606–18.

Article  CAS  PubMed  Google Scholar 

Selkoe DJ. Alzheimer’s disease is a synaptic failure. Science. 2002;298:789–91.

Article  CAS  PubMed  Google Scholar 

Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, et al. A mouse model of amyloid beta oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci. 2010;30:4845–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sivanesan S, Tan A, Rajadas J. Pathogenesis of abeta oligomers in synaptic failure. Curr Alzh Res. 2013;10:316–23.

Article  CAS  Google Scholar 

Ortiz-Sanz C, Gaminde-Blasco A, Valero J, Bakota L, Brandt R, Zugaza JL, et al. Early effects of A beta oligomers on dendritic spine dynamics and arborization in hippocampal neurons. Front Synaptic Neuro. 2020;12:Art2.

Article  Google Scholar 

Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, et al. Evidence for seeding of beta-amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. J Neurosci. 2000;20:3606–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006;313:1781–4.

Article  CAS  PubMed  Google Scholar 

Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, et al. Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Sci USA. 2009;106:12926–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watts JC, Condello C, Stohr J, Oehler A, Lee J, DeArmond SJ, et al. Serial propagation of distinct strains of Abeta prions from Alzheimer’s disease patients. Proc Natl Acad Sci USA. 2014;111:10323–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam S, Herard AS, Boluda S, Petit F, Eddarkaoui S, Cambon K, et al. Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice. Acta Neuropathol Commun. 2022;10:ARTN 112.

Article  Google Scholar 

Stohr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, et al. Distinct synthetic Abeta prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci USA. 2014;111:10329–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gary C, Lam S, Herard AS, Koch JE, Petit F, Gipchtein P, et al. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathol Commun. 2019;7:126.

Article  PubMed  PubMed Central  Google Scholar 

Lam S, Petit F, Hérard A-S, Boluda S, Eddarkaoui S, Guillermier M, et al. Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate. Acta Neuropathol Commun. 2021;9:165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Celestine M, Jacquier-Sarlin M, Borel E, Petit F, Perot JB, Herard AS, et al. Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation. Acta Neuropathol Commun. 2023;11:66.

Leveille F, El Gaamouch F, Gouix E, Lecocq M, Lobner D, Nicole O, et al. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J. 2008;22:4258–71.

Article  CAS  PubMed  Google Scholar 

Rodriguez A, Ehlenberger DB, Dickstein DL, Hof PR, Wearne SL. Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images. PLoS ONE. 2008;3:ARTN e1997.

Article  Google Scholar 

Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, et al. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006;24:516–24.

Article  CAS  PubMed  Google Scholar 

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004;13:159–70.

Article  CAS  PubMed  Google Scholar 

Stohr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, Dearmond SJ, et al. Purified and synthetic Alzheimer’s amyloid beta (Abeta) prions. Proc Natl Acad Sci USA. 2012;109:11025–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franco-Bocanegra DK, McAuley C, Nicoll JAR, Boche D. Molecular mechanisms of microglial motility: changes in ageing and Alzheimer’s disease. Cells-Basel. 2019;8:639–60.

Article  CAS  Google Scholar 

Dejanovic B, Huntley MA, De Maziere A, Meilandt WJ, Wu T, Srinivasan K, et al. Changes in the synaptic proteome in tauopathy and rescue of Tau-induced synapse loss by C1q antibodies. Neuron. 2018;100:1322–1336.e7.

Article  CAS  PubMed  Google Scholar 

Nag S, Sarkar B, Bandyopadhyay A, Sahoo B, Sreenivasan VKA, Kombrabail M, et al. Nature of the amyloid-β monomer and the monomer-oligomer equilibrium. J Biol Chem. 2011;286:13827–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jucker M, Walker LC. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature. 2013;501:45–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

LeVine H. Quantification of beta-sheet amyloid fibril structures with thioflavin T. Method Enzymol. 1999;309:274–84.

Article  CAS  Google Scholar 

Ono K, Takahashi R, Ikeda T, Mizuguchi M, Hamaguchi T, Yamada M. Exogenous amyloidogenic proteins function as seeds in amyloid beta-protein aggregation. Biochim Biophys Acta. 2014;1842:646–53.

Article