The impact of bone mineral density on the risk of falling: evidence from genetic correlation and Mendelian randomization analysis

World Health Organization. Falls. https://www.who.int/news-room/fact-sheets/detail/falls (2021). Accessed 13 Nov 2023

M.M. Montero-Odasso, N. Kamkar, F. Pieruccini-Faria, A. Osman, Y. Sarquis-Adamson, J. Close, D.B. Hogan, S.W. Hunter, R.A. Kenny, L.A. Lipsitz et al. Evaluation of clinical practice guidelines on fall prevention and management for older adults: a systematic review. JAMA Netw. Open 4, e2138911 (2021). https://doi.org/10.1001/jamanetworkopen.2021.38911

Article  PubMed  PubMed Central  Google Scholar 

M. Grivna, H.O. Eid, F.M. Abu-Zidan, Epidemiology, morbidity and mortality from fall-related injuries in the United Arab Emirates. Scand. J. Trauma Resusc. Emerg. Med. 22, 51 (2014). https://doi.org/10.1186/s13049-014-0051-5

Article  PubMed  PubMed Central  Google Scholar 

Y. Li, Z. Huang, Y. Gong, Y. Zheng, Q. Zeng, Retrospective analysis of the relationship between bone mineral density and body composition in a health check-up Chinese population. Front. Endocrinol. 13, 965758 (2022). https://doi.org/10.3389/fendo.2022.965758

Article  Google Scholar 

K. Barbour, J. Stevens, C. Helmick, Y.-H. Luo, L. Murphy, J. Hootman, K. Theis, L. Anderson, N. Baker, D. Sugerman, Falls and fall injuries among adults with arthritis — United States, 2012. Morb. Mortal. Wkly. Rep. 63, 379–383 (2014)

Google Scholar 

F. Hita-Contreras, E. Martínez-López, P. González-Matarín, N. Mendoza, D. Cruz-Díaz, A. Ruiz-Ariza, A. Martínez-Amat, Association of bone mineral density with postural stability and the fear of falling in Spanish postmenopausal women. Maturitas 79, 322–328 (2014). https://doi.org/10.1016/j.maturitas.2014.07.015

Article  PubMed  Google Scholar 

M. Baillet, R. Morello, O. Vittecoq, C. Chavoix, C. Marcelli, Bone, cognitive, and anthropometric profiles and their relation to fracture sites in fallers: a cross-sectional study. Osteoporos. Int. 34, 901–913 (2023). https://doi.org/10.1007/s00198-023-06701-1

Article  PubMed  Google Scholar 

Y. Fu, L. Ba, N. Lü, H. Yang, X. Hong, J. Zhou, Z. Sun, Burden of falls attributable to low bone mineral density among people aged 60 years and over in China from 1990 to 2019. Front. Public Health 11, 1204497 (2023). https://doi.org/10.3389/fpubh.2023.1204497

Article  PubMed  PubMed Central  Google Scholar 

B. Zhu, S. Hu, J. Guo, Z. Dong, Y. Dong, F. Li, Differences in the global exposure, mortality and disability of low bone mineral density between men and women: the underestimated burden in men. BMC Public Health 23, 991 (2023). https://doi.org/10.1186/s12889-023-15947-7

Article  PubMed  PubMed Central  Google Scholar 

M. Aquino, F.J. DiMenna, J. Petrizzo, R.M. Otto, J. Wygand, Power training improves bone mineral density and fall risk for a postmenopausal woman with a history of osteoporosis and increased risk of falling: a case report. J. Bodyw. Mov. Ther. 24, 44–49 (2020). https://doi.org/10.1016/j.jbmt.2020.02.026

Article  PubMed  Google Scholar 

A. Tin, A. Kottgen, Mendelian randomization analysis as a tool to gain insights into causes of diseases: a primer. J. Am. Soc. Nephrol. 32, 2400–2407 (2021). https://doi.org/10.1681/ASN.2020121760

Article  PubMed  PubMed Central  Google Scholar 

N.M. Davies, M.V. Holmes, G. Davey Smith, Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362, k601 (2018)

Article  PubMed  PubMed Central  Google Scholar 

B.K. Bulik-Sullivan, B.M. Neale, LD score regression distinguishes confounding from polygenicity in GWAS. Nat. Genet. 47, 291–295 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

K.C. Tashman, R. Cui, L.J. O’Connor, B.M. Neale, H.K. Finucane, Significance testing for small annotations in stratified LD-Score regression (2021), Preprint at https://www.researchgate.net/publication/350382084_Significance_testing_for_small_annotations_in_stratified_LD-Score_regression

D.A. Lawlor, R.M. Harbord, J.A.C. Sterne, N. Timpson, G. Davey Smith, Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology. Stat. Med. 27, 1133–1163 (2008). https://doi.org/10.1002/sim.3034

Article  PubMed  Google Scholar 

A. Teumer, Common methods for performing Mendelian randomization. Front. Cardiovasc. Med. 5, 51 (2018). https://doi.org/10.3389/fcvm.2018.00051

Article  PubMed  PubMed Central  Google Scholar 

G. Hemani, K. Tilling, G. Davey Smith, Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13, e1007081 (2017). https://doi.org/10.1371/journal.pgen.1007081

Article  CAS  PubMed  PubMed Central  Google Scholar 

H.-F. Zheng, V. Forgetta, Y.-H. Hsu, K. Estrada, A. Rosello-Diez, P.J. Leo, C.L. Dahia, K.H. Park-Min, J.H. Tobias, C. Kooperberg et al. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature 526, 112–117 (2015). https://doi.org/10.1038/nature14878

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Medina-Gomez, J.P. Kemp, K. Trajanoska, J. Luan, A. Chesi, T.S. Ahluwalia, D.O. Mook-Kanamori, A. Ham, F.P. Hartwig, D.S. Evans et al. Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. Am. J. Hum. Genet. 102, 88–102 (2018). https://doi.org/10.1016/j.ajhg.2017.12.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.A. Morris, J.P. Kemp, S.E. Youlten, L. Laurent, J.G. Logan, R.C. Chai, N.A. Vulpescu, V. Forgetta, A. Kleinman, S.T. Mohanty et al. An atlas of genetic influences on osteoporosis in humans and mice. Nat. Genet. 51, 258–266 (2019). https://doi.org/10.1038/s41588-018-0302-x

Article  CAS  PubMed  Google Scholar 

M.I. Kurki, J. Karjalainen, P. Palta, T.P. Sipilä, K. Kristiansson, K.M. Donner, M.P. Reeve, H. Laivuori, M. Aavikko, M.A. Kaunisto et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613, 508–518 (2023). https://doi.org/10.1038/s41586-022-05473-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

K. Trajanoska, L.J. Seppala, C. Medina-Gomez, Y.-H. Hsu, S. Zhou, N.M. van Schoor, L.C.P.G.M. de Groot, D. Karasik, J.B. Richards, D.P. Kiel et al. Genetic basis of falling risk susceptibility in the UK Biobank Study. Commun. Biol. 3, 543 (2020). https://doi.org/10.1038/s42003-020-01256-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

G. Hemani, J. Zheng, B. Elsworth, K.H. Wade, V. Haberland, D. Baird, C. Laurin, S. Burgess, J. Bowden, R. Langdon et al. The MR-Base platform supports systematic causal inference across the human phenome. eLife 7, e34408 (2018). https://doi.org/10.7554/eLife.34408

Article  PubMed  PubMed Central  Google Scholar 

J. Bowden, G. Davey Smith, P.C. Haycock, S. Burgess, Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet. Epidemiol. 40, 304–314 (2016). https://doi.org/10.1002/gepi.21965

Article  PubMed  PubMed Central  Google Scholar 

L. Zhang, B. Mukherjee, M. Ghosh, S. Gruber, V. Moreno, Accounting for error due to misclassification of exposures in case-control studies of gene-environment interaction. Stat. Med. 27, 2756–2783 (2008). https://doi.org/10.1002/sim.3044

Article  PubMed  Google Scholar 

M.D. Tobin, C. Minelli, P.R. Burton, J.R. Thompson, Commentary: development of Mendelian randomization: from hypothesis test to “Mendelian deconfounding”. Int. J. Epidemiol. 33, 26–29 (2004). https://doi.org/10.1093/ije/dyh016

Article  PubMed  Google Scholar 

E. Kulinskaya, M.B. Dollinger, K. Bjørkestøl, On the moments of Cochran’s Q statistic under the null hypothesis, with application to the meta-analysis of risk difference. Res. Synth. Methods 11, 920 (2020). https://doi.org/10.1002/jrsm.1446

Article  PubMed  Google Scholar 

S. Burgess, S.G. Thompson, Interpreting findings from Mendelian randomization using the MR-Egger method. Eur. J. Epidemiol. 32, 377–389 (2017). https://doi.org/10.1007/s10654-017-0255-x

Article  PubMed  PubMed Central  Google Scholar 

F. Wu, Y. Huang, J. Hu, Z. Shao, Mendelian randomization study of inflammatory bowel disease and bone mineral density. BMC Med. 18, 312 (2020). https://doi.org/10.1186/s12916-020-01778-5

Article  CAS  PubMed 

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