Elkis H. Treatment-Resistant Schizophrenia. Psychiatr Clin North Am. 2007;30:511–33.
Iasevoli F, Giordano S, Balletta R, Latte G, Formato MV, Prinzivalli E, et al. Treatment resistant schizophrenia is associated with the worst community functioning among severely-ill highly-disabling psychiatric conditions and is the most relevant predictor of poorer achievements in functional milestones. Prog Neuro-Psychopharmacol Biol Psychiatry. 2016;65:34–48.
Howes OD, McCutcheon R, Agid O, de Bartolomeis A, van Beveren NJM, Birnbaum ML, et al. Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology. Am J Psychiatry. 2017;174:216–29.
Kravariti E, Demjaha A, Zanelli J, Ibrahim F, Wise C, MacCabe JH, et al. Neuropsychological function at first episode in treatment-resistant psychosis: findings from the ÆSOP-10 study. Psychol Med. 2019;49:2100–10.
Yada Y, Yoshimura B, Kishi Y. Correlation between delay in initiating clozapine and symptomatic improvement. Schizophrenia Res. 2015;168:585–6.
Kane JM, Agid O, Baldwin ML, Howes O, Lindenmayer J-P, Marder S, et al. Clinical Guidance on the Identification and Management of Treatment-Resistant Schizophrenia. J Clin Psychiatry. 2019;80:18com12123.
Taylor DM, Young C, Paton C. Prior antipsychotic prescribing in patients currently receiving clozapine: a case note review. J Clin Psychiatry. 2003;64:30–4.
Perkins DO, Gu H, Boteva K, Lieberman JA. Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis. Am J Psychiatry. 2005;162:1785–804.
Agid O, Remington G, Kapur S, Arenovich T, Zipursky RB. Early Use of Clozapine for Poorly Responding First-Episode Psychosis. J Clin Psychopharmacol. 2007;27:369–73.
Article CAS PubMed Google Scholar
Egerton A, Brugger S, Raffin M, Barker GJ, Lythgoe DJ, McGuire PK, et al. Anterior Cingulate Glutamate Levels Related to Clinical Status Following Treatment in First-Episode Schizophrenia. Neuropsychopharmacology. 2012;37:2515–21.
Article CAS PubMed PubMed Central Google Scholar
Demjaha A, Egerton A, Murray RM, Kapur S, Howes OD, Stone JM, et al. Antipsychotic Treatment Resistance in Schizophrenia Associated with Elevated Glutamate Levels but Normal Dopamine Function. Biol Psychiatry. 2014;75:e11–3.
Article CAS PubMed Google Scholar
Mouchlianitis E, Bloomfield MAP, Law V, Beck K, Selvaraj S, Rasquinha N, et al. Treatment-Resistant Schizophrenia Patients Show Elevated Anterior Cingulate Cortex Glutamate Compared to Treatment-Responsive. Schizophrenia Bull. 2016;42:744–52.
Egerton A, Broberg BV, Van Haren N, Merritt K, Barker GJ, Lythgoe DJ, et al. Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE). Mol Psychiatry. 2018;23:2145–55.
Article CAS PubMed Google Scholar
Uno Y, Coyle JT. Glutamate hypothesis in schizophrenia. Psychiatry Clin Neurosci. 2019;73:204–15.
Bendikov I, Nadri C, Amar S, Panizzutti R, Demiranda J, Wolosker H, et al. A CSF and postmortem brain study of d-serine metabolic parameters in schizophrenia. Schizophrenia Res. 2007;90:41–51.
Egerton A, Griffiths K, Casetta C, Deakin B, Drake R, Howes OD, et al. Anterior cingulate glutamate metabolites as a predictor of antipsychotic response in first episode psychosis: data from the STRATA collaboration. Neuropsychopharmacology. 2022;48:567–75.
Article PubMed PubMed Central Google Scholar
McCullumsmith R. Striatal Excitatory Amino Acid Transporter Transcript Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. Neuropsychopharmacology. 2002;26:368–75.
Article CAS PubMed Google Scholar
Afshari P, Myles-Worsley M, Cohen OS, Tiobech J, Faraone SV, Byerley W, et al. Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia. Complex Psychiatry. 2015;1:125–44.
Bjørn-Yoshimoto WE, Underhill SM. The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochemistry Int. 2016;98:4–18.
Underhill SM, Ingram SL, Ahmari SE, Veenstra-VanderWeele J, Amara SG. Neuronal excitatory amino acid transporter EAAT3: Emerging functions in health and disease. Neurochemistry Int. 2019;123:69–76.
Radhakrishnan S, Amara SG Cellular redox regulation by the neuronal glutamate and cysteine transporter, EAAT3. The FASEB Journal. 2022;36:fasebj.2022.36.S1.L7661.
Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, et al. Identification of Multiple Serine Racemase (SRR) mRNA Isoforms and Genetic Analyses of SRR and DAO in Schizophrenia and d-Serine Levels. Biol Psychiatry. 2005;57:1493–503.
Article CAS PubMed Google Scholar
Hashimoto K, Engberg G, Shimizu E, Nordin C, Lindström LH, Iyo M. Reduced d-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients. Prog Neuro-Psychopharmacol Biol Psychiatry. 2005;29:767–9.
Goltsov AY, Loseva JG, Andreeva TV, Grigorenko AP, Abramova LI, Kaleda VG, et al. Polymorphism in the 5′-promoter region of serine racemase gene in schizophrenia. Mol Psychiatry. 2006;11:325–6.
Article CAS PubMed Google Scholar
Tomiya M, Fukushima T, Watanabe H, Fukami G, Fujisaki M, Iyo M, et al. Alterations in serum amino acid concentrations in male and female schizophrenic patients. Clin Chim Acta. 2007;380:186–90.
Article CAS PubMed Google Scholar
Morita Y, Ujike H, Tanaka Y, Otani K, Kishimoto M, Morio A, et al. A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia. Biol Psychiatry. 2007;61:1200–3.
Article CAS PubMed Google Scholar
Ohnuma T, Sakai Y, Maeshima H, Hatano T, Hanzawa R, Abe S, et al. Changes in plasma glycine, l-serine, and d-serine levels in patients with schizophrenia as their clinical symptoms improve: Results from the Juntendo University Schizophrenia Projects (JUSP). Prog Neuro-Psychopharmacol Biol Psychiatry. 2008;32:1905–12.
Hons J, Zirko R, Ulrychova M, Cermakova E, Doubek P, Libiger J. Glycine serum level in schizophrenia: Relation to negative symptoms. Psychiatry Res. 2010;176:103–8.
Article CAS PubMed Google Scholar
Labrie V, Wong AHC, Roder JC. Contributions of the d-serine pathway to schizophrenia. Neuropharmacology. 2012;62:1484–503.
Article CAS PubMed Google Scholar
Coyle JT, Ruzicka WB, Balu DT. Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse. Am J Psychiatry. 2020;177:1119–28.
Article PubMed PubMed Central Google Scholar
Tortorella A, Monteleone P, Fabrazzo M, Viggiano A, De Luca B, Maj M. Plasma Concentrations of Amino Acids in Chronic Schizophrenics Treated with Clozapine. Neuropsychobiology. 2001;44:167–71.
Article CAS PubMed Google Scholar
Yamamori H, Hashimoto R, Fujita Y, Numata S, Yasuda Y, Fujimoto M, et al. Changes in plasma d-serine, l-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment. Neurosci Lett. 2014;582:93–8.
Article CAS PubMed Google Scholar
Heresco-Levy U. Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality. Prog Neuro-Psychopharmacol Biol Psychiatry. 2003;27:1113–23.
Gray L, van den Buuse M, Scarr E, Dean B, Hannan AJ. Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation. Int J Neuropsychopharmacol. 2009;12:45.
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