Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets

Mittal V. Epithelial mesenchymal transition in Tumor Metastasis. Annu Rev Pathol. 2018;13:395–412.

Article  CAS  PubMed  Google Scholar 

Xie X, Li Y, Lian S, Lu Y, Jia L. Cancer metastasis chemoprevention prevents circulating tumour cells from germination. Signal Transduct Target Ther. 2022;7:341.

Article  PubMed  PubMed Central  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.

Article  PubMed  Google Scholar 

Ganesh K, Massagué J. Targeting metastatic cancer. Nat Med. 2021;27:34–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147:275–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Y, Xu J, Lan H. Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications. J Hematol Oncol. 2019;12:76.

Article  PubMed  PubMed Central  Google Scholar 

Roe JS, Hwang CI, Somerville TDD, Milazzo JP, Lee EJ, Da Silva B, Maiorino L, Tiriac H, Young CM, Miyabayashi K, et al. Enhancer reprogramming promotes pancreatic Cancer Metastasis. Cell. 2017;170:875–e888820.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai W, Wu J, Peng X, Hou W, Huang H, Cheng Q, Liu Z, Luyten W, Schoofs L, Zhou J, Liu S. CDK12 orchestrates super-enhancer-associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer. Clin Transl Med. 2022;12:e1087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teng S, Li YE, Yang M, Qi R, Huang Y, Wang Q, Zhang Y, Chen S, Li S, Lin K, et al. Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. Cell Res. 2020;30:34–49.

Article  CAS  PubMed  Google Scholar 

Bradner JE, Hnisz D, Young RA. Transcriptional addiction in Cancer. Cell. 2017;168:629–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thandapani P. Super-enhancers in cancer. Pharmacol Ther. 2019;199:129–38.

Article  CAS  PubMed  Google Scholar 

Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 2013;155:934–47.

Article  CAS  PubMed  Google Scholar 

Wang Y, Nie H, He X, Liao Z, Zhou Y, Zhou J, Ou C. The emerging role of super enhancer-derived noncoding RNAs in human cancer. Theranostics. 2020;10:11049–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 2013;153:307–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan Y, Li Y, Tang F. Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis. Mol Cancer. 2020;19:74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang F, Yang Z, Tan Y, Li Y. Super-enhancer function and its application in cancer targeted therapy. NPJ Precis Oncol. 2020;4:2.

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Hoyle RG, Ma Z, Sun B, Cai W, Cai H, Xie N, Zhang Y, Hou J, Liu X, et al. FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program. Mol Ther. 2021;29:2583–600.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong J, Li J, Li Y, Ma Z, Yu Y, Wang CY. Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma. Nat Commun. 2021;12:3974.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mushimiyimana I, Niskanen H, Beter M, Laakkonen JP, Kaikkonen MU, Ylä-Herttuala S, Laham-Karam N. Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis. Nucleic Acids Res. 2021;49:8078–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell. 2014;26:909–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, et al. CDK7-dependent transcriptional addiction in triple-negative breast cancer. Cell. 2015;163:174–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edgar Serfling MJ, Schaffner W. <enhancers and="eukaryotic=” gene="transcription.pdf=”></enhancers>. Trends Genet 1985, 1.

Heintzman ND, Ren B. Finding distal regulatory elements in the human genome. Curr Opin Genet Dev. 2009;19:541–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wamstad JA, Wang X, Demuren OO, Boyer LA. Distal enhancers: new insights into heart development and disease. Trends Cell Biol. 2014;24:294–302.

Article  CAS  PubMed  Google Scholar 

Hamamoto R, Takasawa K, Shinkai N, Machino H, Kouno N, Asada K, Komatsu M, Kaneko S. Analysis of super-enhancer using machine learning and its application to medical biology. Brief Bioinform 2023, 24.

Hnisz D, Day DS, Young RA. Insulated neighborhoods: structural and functional units of mammalian Gene Control. Cell. 2016;167:1188–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA. A phase separation model for Transcriptional Control. Cell. 2017;169:13–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sabari BR, Dall’Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science 2018, 361.

Fullwood MJ, Wei CL, Liu ET, Ruan Y. Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses. Genome Res. 2009;19:521–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Y, Harigaya Y, Zhang Z, Zhang H, Zang C, Zhang NR. Nonparametric single-cell multiomic characterization of trio relationships between transcription factors, target genes, and cis-regulatory regions. Cell Syst. 2022;13:737–e751734.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei X, Xiang Y, Peters DT, Marius C, Sun T, Shan R, Ou J, Lin X, Yue F, Li W, et al. HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization. Mol Cell. 2022;82:1225–e12381226.

Article 

留言 (0)

沒有登入
gif