Mittal V. Epithelial mesenchymal transition in Tumor Metastasis. Annu Rev Pathol. 2018;13:395–412.
Article CAS PubMed Google Scholar
Xie X, Li Y, Lian S, Lu Y, Jia L. Cancer metastasis chemoprevention prevents circulating tumour cells from germination. Signal Transduct Target Ther. 2022;7:341.
Article PubMed PubMed Central Google Scholar
Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.
Ganesh K, Massagué J. Targeting metastatic cancer. Nat Med. 2021;27:34–44.
Article CAS PubMed PubMed Central Google Scholar
Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147:275–92.
Article CAS PubMed PubMed Central Google Scholar
Lin Y, Xu J, Lan H. Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications. J Hematol Oncol. 2019;12:76.
Article PubMed PubMed Central Google Scholar
Roe JS, Hwang CI, Somerville TDD, Milazzo JP, Lee EJ, Da Silva B, Maiorino L, Tiriac H, Young CM, Miyabayashi K, et al. Enhancer reprogramming promotes pancreatic Cancer Metastasis. Cell. 2017;170:875–e888820.
Article CAS PubMed PubMed Central Google Scholar
Dai W, Wu J, Peng X, Hou W, Huang H, Cheng Q, Liu Z, Luyten W, Schoofs L, Zhou J, Liu S. CDK12 orchestrates super-enhancer-associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer. Clin Transl Med. 2022;12:e1087.
Article CAS PubMed PubMed Central Google Scholar
Teng S, Li YE, Yang M, Qi R, Huang Y, Wang Q, Zhang Y, Chen S, Li S, Lin K, et al. Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. Cell Res. 2020;30:34–49.
Article CAS PubMed Google Scholar
Bradner JE, Hnisz D, Young RA. Transcriptional addiction in Cancer. Cell. 2017;168:629–43.
Article CAS PubMed PubMed Central Google Scholar
Thandapani P. Super-enhancers in cancer. Pharmacol Ther. 2019;199:129–38.
Article CAS PubMed Google Scholar
Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 2013;155:934–47.
Article CAS PubMed Google Scholar
Wang Y, Nie H, He X, Liao Z, Zhou Y, Zhou J, Ou C. The emerging role of super enhancer-derived noncoding RNAs in human cancer. Theranostics. 2020;10:11049–62.
Article CAS PubMed PubMed Central Google Scholar
Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 2013;153:307–19.
Article CAS PubMed PubMed Central Google Scholar
Tan Y, Li Y, Tang F. Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis. Mol Cancer. 2020;19:74.
Article CAS PubMed PubMed Central Google Scholar
Tang F, Yang Z, Tan Y, Li Y. Super-enhancer function and its application in cancer targeted therapy. NPJ Precis Oncol. 2020;4:2.
Article PubMed PubMed Central Google Scholar
Zhang M, Hoyle RG, Ma Z, Sun B, Cai W, Cai H, Xie N, Zhang Y, Hou J, Liu X, et al. FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program. Mol Ther. 2021;29:2583–600.
Article CAS PubMed PubMed Central Google Scholar
Dong J, Li J, Li Y, Ma Z, Yu Y, Wang CY. Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma. Nat Commun. 2021;12:3974.
Article CAS PubMed PubMed Central Google Scholar
Mushimiyimana I, Niskanen H, Beter M, Laakkonen JP, Kaikkonen MU, Ylä-Herttuala S, Laham-Karam N. Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis. Nucleic Acids Res. 2021;49:8078–96.
Article CAS PubMed PubMed Central Google Scholar
Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell. 2014;26:909–22.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, et al. CDK7-dependent transcriptional addiction in triple-negative breast cancer. Cell. 2015;163:174–86.
Article CAS PubMed PubMed Central Google Scholar
Edgar Serfling MJ, Schaffner W. <enhancers and="eukaryotic=” gene="transcription.pdf=”></enhancers>. Trends Genet 1985, 1.
Heintzman ND, Ren B. Finding distal regulatory elements in the human genome. Curr Opin Genet Dev. 2009;19:541–9.
Article CAS PubMed PubMed Central Google Scholar
Wamstad JA, Wang X, Demuren OO, Boyer LA. Distal enhancers: new insights into heart development and disease. Trends Cell Biol. 2014;24:294–302.
Article CAS PubMed Google Scholar
Hamamoto R, Takasawa K, Shinkai N, Machino H, Kouno N, Asada K, Komatsu M, Kaneko S. Analysis of super-enhancer using machine learning and its application to medical biology. Brief Bioinform 2023, 24.
Hnisz D, Day DS, Young RA. Insulated neighborhoods: structural and functional units of mammalian Gene Control. Cell. 2016;167:1188–200.
Article CAS PubMed PubMed Central Google Scholar
Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA. A phase separation model for Transcriptional Control. Cell. 2017;169:13–23.
Article CAS PubMed PubMed Central Google Scholar
Sabari BR, Dall’Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science 2018, 361.
Fullwood MJ, Wei CL, Liu ET, Ruan Y. Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses. Genome Res. 2009;19:521–32.
Article CAS PubMed PubMed Central Google Scholar
Jiang Y, Harigaya Y, Zhang Z, Zhang H, Zang C, Zhang NR. Nonparametric single-cell multiomic characterization of trio relationships between transcription factors, target genes, and cis-regulatory regions. Cell Syst. 2022;13:737–e751734.
Article CAS PubMed PubMed Central Google Scholar
Wei X, Xiang Y, Peters DT, Marius C, Sun T, Shan R, Ou J, Lin X, Yue F, Li W, et al. HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization. Mol Cell. 2022;82:1225–e12381226.
留言 (0)