Biscetti L, Cresta E, Cupini LM, Calabresi P, Sarchielli P (2023) The putative role of neuroinflammation in the complex pathophysiology of migraine: from bench to bedside. Neurobiol Dis 180:106072. https://doi.org/10.1016/j.nbd.2023.106072

Article  CAS  PubMed  Google Scholar 

Malhotra R (2016) Understanding migraine: potential role of neurogenic inflammation. Ann Indian Acad Neurol 19(2):175–182. https://doi.org/10.4103/0972-2327.182302

Article  PubMed  PubMed Central  Google Scholar 

Balcziak LK, Russo AF (2022) Dural Immune Cells, CGRP, and Migraine. Front Neurol 13:874193. https://doi.org/10.3389/fneur.2022.874193

Article  PubMed  PubMed Central  Google Scholar 

Pradalier A, Launay JM (1996) Immunological aspects of migraine. Biomed Pharmacother 50(2):64–70. https://doi.org/10.1016/0753-3322(96)84715-9

Article  CAS  PubMed  Google Scholar 

Moskowitz MA (1993) Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology 43(6 Suppl 3):S16–20

CAS  PubMed  Google Scholar 

Cairns BE, Arendt-Nielsen L, Sacerdote P (2015) Perspectives in Pain Research 2014: Neuroinflammation and glial cell activation: the cause of transition from acute to chronic pain? Scand J Pain 6(1):3–6. https://doi.org/10.1016/j.sjpain.2014.10.002

Article  PubMed  Google Scholar 

Levy D, Labastida-Ramirez A, MaassenVanDenBrink A (2019) Current understanding of meningeal and cerebral vascular function underlying migraine headache. Cephalalgia 39(13):1606–1622. https://doi.org/10.1177/0333102418771350

Article  PubMed  Google Scholar 

Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363(6425):159–163. https://doi.org/10.1038/363159a0

Article  CAS  PubMed  Google Scholar 

Assas BM, Pennock JI, Miyan JA (2014) Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis. Front Neurosci 8:23. https://doi.org/10.3389/fnins.2014.00023

Article  PubMed  PubMed Central  Google Scholar 

Biscetti L, De Vanna G, Cresta E, Bellotti A, Corbelli I, Letizia Cupini M, Calabresi P, Sarchielli P (2022) Immunological findings in patients with migraine and other primary headaches: a narrative review. Clin Exp Immunol 207(1):11–26. https://doi.org/10.1093/cei/uxab025

Article  PubMed  Google Scholar 

Aczél T, Benczik B, Ágg B, Körtési T, Urbán P, Bauer W, Gyenesei A, Tuka B, Tajti J, Ferdinandy P, Vécsei L, Bölcskei K, Kun J, Helyes Z (2022) Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress. J Headache Pain 23(1):113. https://doi.org/10.1186/s10194-022-01478-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, Hempel S, Akl EA, Chang C, McGowan J, Stewart L, Hartling L, Aldcroft A, Wilson MG, Garritty C, Lewin S, Godfrey CM, Macdonald MT, Langlois EV, Soares-Weiser K, Moriarty J, Clifford T, Tunçalp Ö, Straus SE (2018) PRISMA Extension for scoping reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med 169(7):467–473. https://doi.org/10.7326/m18-0850

Article  PubMed  Google Scholar 

Haddaway NR, Page MJ, Pritchard CC, McGuinness LA (2022) PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and open synthesis. Campbell Syst Reviews 18(2):e1230. https://doi.org/10.1002/cl2.1230

Article  Google Scholar 

Wells GAS, O’Connell B, Peterson D, Welch J, Losos V, Tugwell M (2000) P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 2024 Feb 2

Higgins J, Li T, Deeks J (2023) Chap. 6: Choosing effect measures and computing estimates of effect. In: Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, Welch V (eds) Cochrane Handbook for Systematic Reviews of Interventions version 6.4 (updated August 2023). Cochrane

Chaudhry SR, Lendvai IS, Muhammad S, Westhofen P, Kruppenbacher J, Scheef L, Boecker H, Scheele D, Hurlemann R, Kinfe TM (2019) Inter-ictal assay of peripheral circulating inflammatory mediators in migraine patients under adjunctive cervical non-invasive vagus nerve stimulation (nVNS): a proof-of-concept study. Brain Stimul 12(3):643–651. https://doi.org/10.1016/j.brs.2019.01.008

Article  PubMed  Google Scholar 

Hirfanoglu T, Serdaroglu A, Gulbahar O, Cansu A (2009) Prophylactic drugs and cytokine and leptin levels in children with migraine. Pediatr Neurol 41(4):281–287. https://doi.org/10.1016/j.pediatrneurol.2009.04.019

Article  PubMed  Google Scholar 

ArmaĞAn HH, Karaman K, YalÇIn Yilmaz D (2020) Antioxidant and cytokine levels in plasma of patients with attack and non-attack periods. J Cell Neurosci Oxidative Stress 12(1):914–921. https://doi.org/10.37212/jcnos.806797

Article  Google Scholar 

Lee YY, Yang YP, Huang PI, Li WC, Huang MC, Kao CL, Chen YJ, Chen MT (2015) Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine. Brain Res Bull 116:98–105. https://doi.org/10.1016/j.brainresbull.2015.06.005

Article  CAS  PubMed  Google Scholar 

Uzar E, Evliyaoglu O, Yucel Y, Ugur Cevik M, Acar A, Guzel I, Islamoglu Y, Colpan L, Tasdemir N (2011) Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Eur Rev Med Pharmacol Sci 15(10):1111–1116

CAS  PubMed  Google Scholar 

Yücel M, Kotan D, Gurol Çiftçi G, Çiftçi IH, Cikriklar HI (2016) Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci 20(5):930–936

PubMed  Google Scholar 

Flook M, Frejo L, Gallego-Martinez A, Martin-Sanz E, Rossi-Izquierdo M, Amor-Dorado JC, Soto-Varela A, Santos-Perez S, Batuecas-Caletrio A, Espinosa-Sanchez JM, Pérez-Carpena P, Martinez-Martinez M, Aran I, Lopez-Escamez JA (2019) Differential Proinflammatory signature in vestibular migraine and Meniere Disease. Front Immunol 10:1229. https://doi.org/10.3389/fimmu.2019.01229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karaaslan Z, Özçelik P, Ulukan Ç, Ulusoy C, Orhan KS, Orhan EK, Küçükali C, Tüzün E, Baykan B, Akdal G (2020) Plasma levels of inflammatory mediators in vestibular migraine. Int J Neurosci 130(4):330–335. https://doi.org/10.1080/00207454.2019.1681994

Article  CAS  PubMed  Google Scholar 

Mueller L, Gupta AK, Stein TP (2001) Deficiency of tumor necrosis factor alpha in a subclass of menstrual migraineurs. Headache 41(2):129–137. https://doi.org/10.1046/j.1526-4610.2001.111006129.x

Article  CAS  PubMed  Google Scholar 

Oliveira AB, Bachi ALL, Ribeiro RT, Mello MT, Tufik S, Peres MFP (2017) Unbalanced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes. J Neuroimmunol 313:138–144. https://doi.org/10.1016/j.jneuroim.2017.09.008

Article  CAS  PubMed  Google Scholar 

Perini F, D’Andrea G, Galloni E, Pignatelli F, Billo G, Alba S, Bussone G, Toso V (2005) Plasma cytokine levels in migraineurs and controls. Headache 45(7):926–931. https://doi.org/10.1111/j.1526-4610.2005.05135.x

Article  PubMed  Google Scholar 

Fidan I, Yüksel S, Ymir T, Irkeç C, Aksakal FN (2006) The importance of cytokines, chemokines and nitric oxide in pathophysiology of migraine. J Neuroimmunol 171(1–2):184–188. https://doi.org/10.1016/j.jneuroim.2005.10.005

Article  CAS  PubMed  Google Scholar 

Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, Floridi A, Calabresi P (2006) Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache 46(2):200–207. https://doi.org/10.1111/j.1526-4610.2006.00337.x

Article  PubMed  Google Scholar 

van Hilten JJ, Ferrari MD, Van der Meer JW, Gijsman HJ, Looij BJ Jr (1991) Plasma interleukin-1, tumour necrosis factor and hypothalamic-pituitary-adrenal axis responses during migraine attacks. Cephalalgia 11(2):65–67. https://doi.org/10.1046/j.1468-2982.1991.1102065.x

Article  PubMed  Google Scholar 

Aydın M, Demir C, Arıkanoğlu A, Bulut S, Ilhan N (2015) Plasma cytokine levels in migraineurs during and outside of attacks. Electron J Gen Med 12:307–312. https://doi.org/10.15197/ejgm.01255

Article  CAS  Google Scholar 

Domínguez C, Vieites-Prado A, Pérez-Mato M, Sobrino T, Rodríguez-Osorio X, López A, Campos F, Martínez F, Castillo J, Leira R (2018) CGRP and PTX3 as predictors of efficacy of Onabotulinumtoxin Type A in Chronic Migraine: an observational study. Headache 58(1):78–87. https://doi.org/10.1111/head.13211