Shimabukuro-Vornhagen A, et al. Critical care management of chimeric antigen receptor T-cell therapy recipients. Ca-Cancer J Clin. 2022;72:78–93.
Rafiq S, Hackett CS, Brentjens RJ. Engineering strategies to overcome the current roadblocks in CAR T cell therapy. Nat Rev Clin Oncol. 2020;17:147–67.
Grupp SA, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368:1509–18.
Article CAS PubMed PubMed Central Google Scholar
Cao J, et al. Potent anti-leukemia activities of humanized CD19-targeted chimeric antigen receptor T (CAR-T) cells in patients with relapsed/refractory acute lymphoblastic leukemia. Am J Hematol. 2018;93:851–8.
Article CAS PubMed Google Scholar
Chow A, Perica K, Klebanoff CA, Wolchok JD. Clinical implications of T cell exhaustion for cancer immunotherapy. Nat Rev Clin Oncol. 2022;19:775–90.
Article PubMed PubMed Central Google Scholar
Deng Q, et al. Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas. Nat Med. 2020;26:1878–87.
Article CAS PubMed PubMed Central Google Scholar
Ferrer G, Alvarez-Errico D, Esteller M. Biological and molecular factors Predicting Response to Adoptive Cell therapies in Cancer. J Natl Cancer Inst. 2022;114:930–9.
Article PubMed PubMed Central Google Scholar
Andrea AE, et al. Advances in CAR-T Cell Genetic Engineering Strategies to Overcome hurdles in Solid Tumors Treatment. Front Immunol. 2022;13:830292.
Article CAS PubMed PubMed Central Google Scholar
Gumber D, Wang LD, Improving. CAR-T immunotherapy: overcoming the challenges of T cell exhaustion. EBioMedicine. 2022;77:103941.
Article CAS PubMed PubMed Central Google Scholar
Newick K, O’Brien S, Moon E, Albelda SM. CAR T cell therapy for solid tumors. Annu Rev Med. 2017;68:139–52.
Article CAS PubMed Google Scholar
Pan K, et al. CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy. J Exp Clin Cancer Res. 2022;41:119.
Article CAS PubMed PubMed Central Google Scholar
Christofides A, et al. The complex role of tumor-infiltrating macrophages. Nat Immunol. 2022;23:1148–56.
Article CAS PubMed PubMed Central Google Scholar
Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21:799–820.
Article CAS PubMed PubMed Central Google Scholar
Chen SZ et al. Macrophages in immunoregulation and therapeutics. Signal Transduct Tar 8, (2023).
DeNardo DG, Ruffell B. Macrophages as regulators of tumour immunity and immunotherapy. Nat Rev Immunol. 2019;19:369–82.
Article CAS PubMed PubMed Central Google Scholar
Biglari A, Southgate TD, Fairbairn LJ, Gilham DE. Human monocytes expressing a CEA-specific chimeric CD64 receptor specifically target CEA-expressing tumour cells in vitro and in vivo. Gene Ther. 2006;13:602–10.
Article CAS PubMed Google Scholar
Wang S, et al. CAR-macrophage: an extensive immune enhancer to fight cancer. EBioMedicine. 2022;76:103873.
Article CAS PubMed PubMed Central Google Scholar
Bauml J et al. A phase 1, first in human study of adenovirally transduced autologous macrophages engineered to contain an anti-HER2 chimeric antigen receptor (CAR) in subjects with HER2 overexpressing solid tumors. J Clin Oncol 39, (2021).
Finck AV, Blanchard T, Roselle CP, Golinelli G, June CH. Engineered cellular immunotherapies in cancer and beyond. Nat Med. 2022;28:678–89.
Article CAS PubMed PubMed Central Google Scholar
Irvine DJ, Maus MV, Mooney DJ, Wong WW. The future of engineered immune cell therapies. Science. 2022;378:853–8.
Article CAS PubMed PubMed Central Google Scholar
Lecoultre M, Dutoit V, Walker PR. Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review. J Immunother Cancer 8, (2020).
Morrissey MA et al. Chimeric antigen receptors that trigger phagocytosis. Elife 7, (2018).
Zhang WL, et al. Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix. Brit J Cancer. 2019;121:837–45.
Article CAS PubMed PubMed Central Google Scholar
Zhang L, et al. Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions. J Hematol Oncol. 2020;13:153.
Article CAS PubMed PubMed Central Google Scholar
Niu Z, et al. Chimeric antigen receptor-modified macrophages trigger systemic anti-tumour immunity. J Pathol. 2021;253:247–57.
Article CAS PubMed Google Scholar
Kloosterman DJ, Akkari L. Macrophages at the interface of the co-evolving cancer ecosystem. Cell. 2023;186:1627–51.
Article CAS PubMed Google Scholar
Cassetta L, Pollard JW. A timeline of tumour-associated macrophage biology. Nat Rev Cancer. 2023;23:238–57.
Article CAS PubMed Google Scholar
Sloas C, Gill S, Klichinsky M. Engineered CAR-Macrophages as adoptive immunotherapies for solid tumors. Front Immunol 12, (2021).
Liu Q, et al. Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T. Mol Cancer. 2023;22:28.
Article PubMed PubMed Central Google Scholar
Su S, et al. Immune Checkpoint Inhibition overcomes ADCP-Induced Immunosuppression by macrophages. Cell. 2018;175:442–57. e423.
Article CAS PubMed Google Scholar
Villanueva MT. Macrophages get a CAR. Nat Rev Cancer. 2020;20:300.
Article CAS PubMed Google Scholar
Anderson NR, Minutolo NG, Gill S, Klichinsky M. Macrophage-based approaches for Cancer Immunotherapy. Cancer Res. 2021;81:1201–8.
Article CAS PubMed Google Scholar
Backlund C, Jalili-Firoozinezhad S, Kim B, Irvine DJ. Biomaterials-mediated Engineering of the Immune System. Annu Rev Immunol. 2023;41:153–79.
Article CAS PubMed PubMed Central Google Scholar
Kang M, et al. Nanocomplex-mediated in vivo programming to chimeric Antigen Receptor-M1 macrophages for Cancer Therapy. Adv Mater. 2021;33:e2103258.
Zheng CX et al. Anti-phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy. Sci Adv 9, (2023).
Chen C et al. Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy. Sci Transl Med 14, (2022).
Raimondo TM, Reed K, Shi DN, Langer R, Anderson DG. Delivering the next generation of cancer immunotherapies with RNA. Cell. 2023;186:1535–40.
Article CAS PubMed Google Scholar
Wang X, et al. Metabolic reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors. Nat Commun. 2023;14:5778.
Article CAS PubMed PubMed Central Google Scholar
Reiss KA et al. A phase 1, first-in-human (FIH) study of adenovirally transduced autologous macrophages engineered to contain an anti-HER2 chimeric antigen receptor (CAR) in subjects with HER2 overexpressing solid tumors. J Clin Oncol 40, (2022).
Klichinsky M et al. CT-0508 is an anti-HER2 chimeric antigen receptor (CAR) macrophage with targeted anti-tumor activity that promotes a pro-inflammatory solid tumor microenvironment. Cancer Res 80, (2020).
Klichinsky M, et al. Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol. 2020;38:947–953.
Article CAS PubMed PubMed Central Google Scholar
Annunziata CM, et al. Feasibility and preliminary safety and efficacy of first-in-human intraperitoneal delivery of MCY-M11, anti-human-mesothelin CAR mRNA transfected into peripheral blood mononuclear cells, for ovarian cancer and malignant peritoneal mesothelioma. J Clin Oncol. 2020;38:3014–3014.
Schepisi G et al. The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) cell and macrophage (CAR-M) therapy against breast Cancer. Cancers (Basel) 15, (2023).
Myeloid Therapeutics Doses First Patient with MT-101 in the IMAGINE Phase 1/2 Clinical Study, https://myeloidtx.com/myeloid-therapeutics-doses-first-patient-with-mt-101-in-the-imagine-phase-1-2-clinical-study/ (2023). Accessed 12 Dec 2023.
Zhang J, et al. The second generation of human iPSC-Derived CAR-Macrophages for Immune Cell therapies in Liquid and solid tumors. Blood. 2022;140:9238–9.
Labanieh L, Mackall CL. CAR immune cells: design principles, resistance and the next generation. Nature. 2023;614:635–48.
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