A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

Lamont, R. J., Koo, H. & Hajishengallis, G. The oral microbiota: dynamic communities and host interactions. Nat. Rev. Microbiol. 16, 745–759 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papapanou, P. N. et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Periodontol. 89, S173–S182 (2018).

Article  PubMed  Google Scholar 

Torres, A. et al. Proteomic profile of human gingival crevicular fluid reveals specific biological and molecular processes during clinical progression of periodontitis. J. Periodontal. Res. https://doi.org/10.1111/jre.13169 (2023).

Dixon, S. J. et al. Ferroptosis: An Iron-Dependent Form of Nonapoptotic. Cell Death. Cell 149, 1060–1072 (2012).

CAS  PubMed  Google Scholar 

Amaral, E. P. et al. A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis. J. Exp. Med. 216, 556–570 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dar, H. H. et al. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J. Clin. Investig. 128, 4639–4653 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Pajuelo, D. et al. NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis. Cell Rep. 24, 429–440 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei, S. et al. Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice. Clin. Transl. Med. 10, e173 (2020).

do Van, B. et al. Ferroptosis, a newly characterized form of cell death in Parkinson’s disease that is regulated by PKC. Neurobiol. Dis. 94, 169–178 (2016).

Article  PubMed  Google Scholar 

Hassannia, B., Vandenabeele, P. & vanden Berghe, T. Targeting Ferroptosis to Iron Out Cancer. Cancer Cell 35, 830–849 (2019).

Article  CAS  PubMed  Google Scholar 

Sun, Y. et al. The emerging role of ferroptosis in inflammation. Biomed. Pharmacother. 127, 110108 (2020).

Article  CAS  PubMed  Google Scholar 

Weiland, A. et al. Ferroptosis and Its Role in Diverse Brain Diseases. Mol. Neurobiol. 56, 4880–4893 (2019).

Article  CAS  PubMed  Google Scholar 

Boyer, E. et al. Increased transferrin saturation is associated with subgingival microbiota dysbiosis and severe periodontitis in genetic haemochromatosis. Sci. Rep. 8, 15532 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Guo, L.-N., Yang, Y.-Z. & Feng, Y.-Z. Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus. BMC Oral. Health 18, 63 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Mukherjee, S. The Role of Crevicular Fluid Iron in Periodontal Disease. J. Periodontol. 56, 22–27 (1985).

Article  CAS  PubMed  Google Scholar 

Bains, R. & Bains, V. The antioxidant master glutathione and periodontal health. Dent. Res J. 12, 389 (2015).

Article  Google Scholar 

Grant, M. M., Brock, G. R., Matthews, J. B. & Chapple, I. L. C. Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy. J. Clin. Periodontol. 37, 17–23 (2010).

Article  CAS  PubMed  Google Scholar 

Wang, Y., Andrukhov, O. & Rausch-Fan, X. Oxidative Stress and Antioxidant System in Periodontitis. Front. Physiol. 8, 910 (2017).

Xing, L. et al. Fibroblast ferroptosis is involved in periodontitis-induced tissue damage and bone loss. Int Immunopharmacol. 114, 109607 (2023).

Article  CAS  PubMed  Google Scholar 

Fu, E. et al. Role of ferroptosis in periodontitis: An animal study in rats. J. Periodontal Res. 58, 1031–1040 (2023).

Article  CAS  PubMed  Google Scholar 

Wong, S. L. & Wagner, D. D. Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging. FASEB J. 32, 6258–6370 (2018).

Article  Google Scholar 

Li, P. et al. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 207, 1853–1862 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koopman, G. et al. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84, 1415–1420 (1994).

Article  CAS  PubMed  Google Scholar 

Vermes, I., Haanen, C., Steffens-Nakken, H. & Reutellingsperger, C. A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184, 39–51 (1995).

Article  CAS  PubMed  Google Scholar 

Leppilahti, J. M., Kallio, M. A., Tervahartiala, T., Sorsa, T. & Mäntylä, P. Gingival Crevicular Fluid Matrix Metalloproteinase-8 Levels Predict Treatment Outcome Among Smokers With Chronic Periodontitis. J. Periodontol. 85, 250–260 (2014).

Article  CAS  PubMed  Google Scholar 

Hernández, M. et al. Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study. J. Periodontol. 81, 1644–1652 (2010).

Article  PubMed  Google Scholar 

Sorsa, T. et al. Analysis of matrix metalloproteinases, especially MMP-8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontology 70, 142–163 (2016).

Article  Google Scholar 

Baeza, M. et al. Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study. J. Clin. Periodontol. 43, 34–45 (2016).

Article  CAS  PubMed  Google Scholar 

Tymkiw, K. D. et al. Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis. J. Clin. Periodontol. 38, 219–228 (2011).

Article  CAS  PubMed  Google Scholar 

Hernández, M. et al. MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients’, Mild and Severe Periodontitis Sites. Biomolecules 10, 1500 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Teles, R. et al. Patterns of periodontal disease progression based on linear mixed models of clinical attachment loss. J. Clin. Periodontol. 45, 15–25 (2018).

Article  PubMed  Google Scholar 

Teles, R. P., Patel, M., Socransky, S. S. & Haffajee, A. D. Disease Progression in Periodontally Healthy and Maintenance Subjects. J. Periodontol. 79, 784–794 (2008).

Article  CAS  PubMed  Google Scholar 

Teles, R. et al. Modelling changes in clinical attachment loss to classify periodontal disease progression. J. Clin. Periodontol. 43, 426–434 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Papapanou, P. N., Wennström, J. L. & Gröndahl, K. A 10–year retrospective study of periodontal disease progression. J. Clin. Periodontol. 16, 403–411 (1989).

Article  CAS  PubMed  Google Scholar 

Schätzle, M. et al. Clinical course of chronic periodontitis. J. Clin. Periodontol. 30, 909–918 (2003).

Article  PubMed  Google Scholar 

Gilthorpe, M. S. et al. Unification of the ‘Burst’ and ‘Linear’ Theories of Periodontal Disease Progression: A Multilevel Manifestation of the Same Phenomenon. J. Dent. Res. 82, 200–205 (2003).

Article  CAS  PubMed  Google Scholar 

Bibi, T. et al. Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases. Molecules 26, 1208 (2021).

Article  PubMed Central  Google Scholar 

Bostanci, N. & Belibasakis, G. N. Gingival crevicular fluid and its immune mediators in the proteomic era. Periodontology 76, 68–84 (2018).

Article  Google Scholar 

Baliban, R. C. et al. Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples. J. Clin. Periodontol. 39, 203–212 (2012).

Article  CAS  PubMed  Google Scholar 

Tsuchida, S. et al. Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers. Proteomics 12, 2190–2202 (2012).

Article  CAS  PubMed  Google Scholar 

Fentoğlu, Ö. et al. Evaluation of Lipid Peroxidation and Oxidative DNA Damage in Patients With Periodontitis and Hyperlipidemia. J. Periodontol. 86, 682–688 (2015).

Article  PubMed  Google Scholar 

Akalιn, F. A., Baltacιoğlu, E., Alver, A. & Karabulut, E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J. Clin. Perio

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