Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang H-Y, Ahima RS et al (2018) Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol 14:168–181. https://doi.org/10.1038/nrneurol.2017.185
Article CAS PubMed PubMed Central Google Scholar
Baranowska-Bik A, Uchman D, Litwiniuk A, Kalisz M, Martyńska L, Baranowska B et al (2020) Peripheral levels of selected adipokines in patients with newly diagnosed multiple sclerosis. Endokrynol Pol 71:109–115. https://doi.org/10.5603/EP.a2020.0008
Article CAS PubMed Google Scholar
Borys J, Maciejczyk M, Antonowicz B, Krętowski A, Sidun J, Domel E et al (2019) Glutathione metabolism, mitochondria activity, and nitrosative stress in patients treated for mandible fractures. J Clin Med 8:127. https://doi.org/10.3390/jcm8010127
Article CAS PubMed PubMed Central Google Scholar
Cetinkalp S, Simsir IY, Ertek S (2014) Insulin resistance in brain and possible therapeutic approaches. Curr Vasc Pharmacol 12:553–564. https://doi.org/10.2174/1570161112999140206130426
Article CAS PubMed Google Scholar
El-Malkey NF, RedaAshour WM, Mahdy MEM, Mohamed HAE, Moussa AMA (2016) The interplay between inflammation and metabolic disturbances in multiple sclerosis. Life Sci J 13:1–11. https://doi.org/10.7537/marslsj13071601
European Centre for Disease Prevention and Control (2019) Managing heterogeneity when pooling data from different surveillance systems, https://www.ecdc.europa.eu/en/publications-data/managing-heterogeneity-when-pooling-data-different-surveillance-systems Accessed 25 May 2023
Frisardi V, Solfrizzi V, Seripa D, Capurso C, Santamato A, Sancarlo D et al (2010) Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer’s disease. Ageing Res Rev 9:399–417. https://doi.org/10.1016/j.arr.2010.04.007
Goldman M, Koenig S, Yeamans R, Johnston K (2014) A study of insulin resistance in multiplesclerosis subjects and healthy controls. Neurology 82:171
Gray SM, Meijer RI, Barrett EJ (2014) Insulin regulates brain function, but how does it get there? Diabetes 63:3992–3997. https://doi.org/10.2337/db14-0340
Article CAS PubMed PubMed Central Google Scholar
Hardoňová M, Šiarnik P, Sivakova M, Sucha B, Vlček M, Imrich R et al (2021) Autonomic nervous system function in newly diagnosed multiple sclerosis: Association with lipid levels and insulin resistance. Physiol Res 70:875–882. https://doi.org/10.33549/physiolres.934695
Article CAS PubMed PubMed Central Google Scholar
Holloway GP, Han XX, Jain SS, Bonen A, Chabowski A (2014) Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats. Diabetologia 57:832–840. https://doi.org/10.1007/s00125-014-3169-0
Article CAS PubMed Google Scholar
Hussein WI, Reddy SS (2006) Prevalence of diabetes in patients with multiple sclerosis. Diabetes Care 29:1984–1985. https://doi.org/10.2337/dc06-0811
James DE, Stöckli J, Birnbaum MJ (2021) The aetiology and molecular landscape of insulin resistance. Nat Rev Mol Cell Biol 22:751–771. https://doi.org/10.1038/s41580-021-00390-6
Article CAS PubMed Google Scholar
Keytsman C, Eijnde BO, Hansen D, Verboven K, Wens I (2017) Elevated cardiovascular risk factors in multiple sclerosis. Mult Scler Relat Disord 17:220–223. https://doi.org/10.1016/j.msard.2017.08.011
Koskderelioglu A, Gedizlioglu M, Eskut N, Tamer P, Yalcin G, Bozkaya G (2021) Impact of chemerin, lipid profile, and insulin resistance on disease parameters in patients with multiple sclerosis. Neurol Sci 42:2471–2479. https://doi.org/10.1007/s10072-020-04847-y
Kostić S, Kolić I, Raičević R, Stojanović Z, Kostić D, Dinčić E (2017) Insulin resistance in drug naive patients with multiple sclerosis. Vojnosanit Pregl 74:564–571. https://doi.org/10.2298/VSP160218082K
Krogh-Madsen R, Plomgaard P, Keller P, Keller C, Pedersen BK (2004) Insulin stimulates interleukin-6 and tumor necrosis factor-α gene expression in human subcutaneous adipose tissue. Am J Physiol Endocrinol Metab 286:234–238. https://doi.org/10.1152/ajpendo.00274.2003
Küçük A, Bir LS, Tekin S, Demir S (2022) Serum 25 (OH) vitamin D level in relapsing-remitting multiple sclerosis and clinically isolated syndrome groups. Horm Mol Biol Clin Investig 43:281–288. https://doi.org/10.1515/hmbci-2021-0074
Article CAS PubMed Google Scholar
Macesic M, Lalic NM, Kostic VS, Jotic A, Lalic K, Stefanova E et al (2017) Impaired insulin sensitivity and secretion in patients with Alzheimer’s disease: the relationship with other atherosclerosis risk factors. Curr Vasc Pharmacol 15(2):158–166. https://doi.org/10.2174/1570161114666160905170644
Article CAS PubMed Google Scholar
Maciejczyk M, Żebrowska E, Chabowski A (2019) Insulin resistance and oxidative stress in the brain: what’s new? Int J Mol Sci 20:874. https://doi.org/10.3390/ijms20040874
Article CAS PubMed PubMed Central Google Scholar
Magyari M, Sorensen S (2020) Comorbidity in multiple sclerosis. Front Neurol 11:851. https://doi.org/10.3389/fneur.2020.00851
Article PubMed PubMed Central Google Scholar
Mähler A, Steiniger J, Bock M, Brandt AU, Haas V, Boschmann M et al (2012) Is metabolic flexibility altered in multiple sclerosis patients? PLoS ONE 7:e43675. https://doi.org/10.1371/journal.pone.0043675
Article CAS PubMed PubMed Central Google Scholar
Mansoor SR, Zabihi E, Ghasemi-Kasman M (2019) The potential use of mesenchymal stem cells for the treatment of multiple sclerosis. Life Sci 235:116830. https://doi.org/10.1016/j.lfs.2019.116830
Article CAS PubMed Google Scholar
Maric G, Lalic K, Pekmezovic T, Tamas O, Rajkovic N, Rasulic I et al (2020) Could the performance of oral glucose tolerance test contribute to the brain health-focused care in multiple sclerosis? Mult Scler Relat Disord 46:102536. https://doi.org/10.1016/j.msard.2020.102536
Marrie RA, Cohen J, Stuve O, Trojano M, Sørensen PS, Reingold S et al (2015) A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview. Mult Scler 21:263–281. https://doi.org/10.1177/1352458514564491
Article PubMed PubMed Central Google Scholar
Mathur D, López-Rodas G, Casanova B, Marti MB (2014) Perturbed glucose metabolism: insights into multiple sclerosis pathogenesis. Front Neurol 5:250. https://doi.org/10.3389/fneur.2014.00250
Article PubMed PubMed Central Google Scholar
Michalak S, Jernas L, Wysocka E, Osztynowicz K, Kupczyk E (2014) The effect of methylprednisolone, interferon beta and glatiramer acetate treatment on the levels of leptin, adiponectin and resistin in multiple sclerosis patients. J Neurol Neurophysiol S 12. https://doi.org/10.4172/2155-9562.S12-005
Nelson TJ, Sun MK, Hongpaisan J, Alkon DL (2008) Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. Eur J Pharmacol 585:76–787. https://doi.org/10.1016/j.ejphar.2008.01.051
Article CAS PubMed Google Scholar
Niino M, Iwabuchi K, Kikuchi S, Ato M, Morohashi T, Ogata A et al (2001) Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-γ. J Neuroimmunol 116:40–48. https://doi.org/10.1016/S0165-5728(01)00285-5
Article CAS PubMed Google Scholar
Oliveira SR, Kallaur AP, Lopes J, Simão ANC, Reiche EM, de Almeida ERD et al (2014) Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: associations with inflammatory and oxidative stress biomarkers and uric acid. Psychiatry Res 250:113–120. https://doi.org/10.1016/j.psychres.2016.12.039
Oliveira SR, Kallaur AP, Lopes J, Simão ANC, Reiche EM, de Almeida ERD et al (2017) Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: associations with inflammatory and oxidative stress biomarkers and uric acid. Psychiatry Res 250:113–120. https://doi.org/10.1016/j.psychres.2016.12.039
Article CAS PubMed Google Scholar
Penesova A, Vlcek M, Imrich R, Vernerova L, Marko A, Meskova M et al (2015) Hyperinsulinemia in newly diagnosed patients with multiple sclerosis. Metab Brain Dis 30:895–901. https://doi.org/10.1007/s11011-015-9665-1
Article CAS PubMed Google Scholar
Pomytkin I, Costa-Nunes JP, Kasatkin V, Veniaminova E, Demchenko A, Lyundup A, Lesch KP, Ponomarev ED, Strekalova T (2018) Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment. CNS Neurosci Ther 24:763–774. https://doi.org/10.1111/cns.12866
Article CAS PubMed PubMed Central Google Scholar
Pugliatti M, Harbo HF, Holmøy T, Kampman MT, Myhr K, Riise T, Wolfson C (2008) Environmental risk factors in multiple sclerosis. Acta Neurol Scand 117:34–40. https://doi.org/10.1111/j.1600-0404.2008.01029.x
Radikova Z, Penesova A, Vlcek M, Havranova A, Sivakova M, Siarnik P et al (2018) LDL and HDL lipoprotein subfractions in multiple sclerosis patients with decreased insulin sensitivity. Endocr Regul 52:139–145. https://doi.org/10.2478/enr-2018-0017
Rhea EM, Banks WA (2019) Role of the blood-brain barrier in central nervous system insulin resistance. Front Neurol 13:521. https://doi.org/10.3389/fnins.2019.00521
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