Zekeridou A, McKeon A, Lennon VA. Frequency of synaptic autoantibody accompaniments and neurological manifestations of Thymoma. JAMA Neurol. 2016;73:853–9.
Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. Introduction to the 2015 World Health Organization Classification of Tumors of the lung, Pleura, Thymus, and heart. J Thorac Oncol. 2015;10:1240–2.
Cufi P, Dragin N, Ruhlmann N, Weiss JM, Fadel E, Serraf A, Berrih-Aknin S, Le Panse R. Central role of interferon-beta in thymic events leading to myasthenia gravis. J Autoimmun. 2014;52:44–52.
Article CAS PubMed Google Scholar
Cufi P, Soussan P, Truffault F, Fetouchi R, Robinet M, Fadel E, Berrih-Aknin S, Le Panse R. Thymoma-associated myasthenia gravis: on the search for a pathogen signature. J Autoimmun. 2014;52:29–35.
Article CAS PubMed Google Scholar
Strobel P, Murumagi A, Klein R, Luster M, Lahti M, Krohn K, Schalke B, Nix W, Gold R, Rieckmann P, et al. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J Pathol. 2007;211:563–71.
Article CAS PubMed Google Scholar
Marx A, Pfister F, Schalke B, Saruhan-Direskeneli G, Melms A, Strobel P. The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. Autoimmun Rev. 2013;12:875–84.
Article CAS PubMed Google Scholar
Marx A, Porubsky S, Belharazem D, Saruhan-Direskeneli G, Schalke B, Strobel P, Weis CA. Thymoma related myasthenia gravis in humans and potential animal models. Exp Neurol. 2015;270:55–65.
Scarpino S, Di Napoli A, Stoppacciaro A, Antonelli M, Pilozzi E, Chiarle R, Palestro G, Marino M, Facciolo F, Rendina EA, et al. Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. Clin Exp Immunol. 2007;149:504–12.
Article CAS PubMed PubMed Central Google Scholar
Suzuki E, Kobayashi Y, Yano M, Fujii Y. Infrequent and low AIRE expression in thymoma: difference in AIRE expression among WHO subtypes does not correlate with association of MG. Autoimmunity. 2008;41:377–82.
Article CAS PubMed Google Scholar
Iacomino N, Scandiffio L, Conforti F, Salvi E, Tarasco MC, Bortone F, Marcuzzo S, Simoncini O, Andreetta F, Pistillo D, et al. Muscle and muscle-like Autoantigen expression in Myasthenia gravis Thymus: possible molecular hint for autosensitization. Biomedicines. 2023;11:732.
Article CAS PubMed PubMed Central Google Scholar
Luther C, Adamopoulou E, Stoeckle C, Brucklacher-Waldert V, Rosenkranz D, Stoltze L, Lauer S, Poeschel S, Melms A, Tolosa E. Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients. J Immunol. 2009;183:841–8.
Article CAS PubMed Google Scholar
Strobel P, Rosenwald A, Beyersdorf N, Kerkau T, Elert O, Murumagi A, Sillanpaa N, Peterson P, Hummel V, Rieckmann P, et al. Selective loss of regulatory T cells in thymomas. Ann Neurol. 2004;56:901–4.
Hoffacker V, Schultz A, Tiesinga JJ, Gold R, Schalke B, Nix W, Kiefer R, Muller-Hermelink HK, Marx A. Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood. 2000;96:3872–9.
Article CAS PubMed Google Scholar
Buckley C, Douek D, Newsom-Davis J, Vincent A, Willcox N. Mature, long-lived CD4 + and CD8 + T cells are generated by the thymoma in myasthenia gravis. Ann Neurol. 2001;50:64–72.
Article CAS PubMed Google Scholar
Strobel P, Helmreich M, Menioudakis G, Lewin SR, Rudiger T, Bauer A, Hoffacker V, Gold R, Nix W, Schalke B, et al. Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas. Blood. 2002;100:159–66.
Article CAS PubMed Google Scholar
Balandina A, Saoudi A, Dartevelle P, Berrih-Aknin S. Analysis of CD4 + CD25 + cell population in the thymus from myasthenia gravis patients. Ann N Y Acad Sci. 2003;998:275–7.
Article CAS PubMed PubMed Central Google Scholar
Luther C, Poeschel S, Varga M, Melms A, Tolosa E. Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. J Neuroimmunol. 2005;164:124–8.
Article CAS PubMed Google Scholar
Kohler S, Keil TOP, Hoffmann S, Swierzy M, Ismail M, Ruckert JC, Alexander T, Meisel A. CD4(+) FoxP3(+) T regulatory cell subsets in myasthenia gravis patients. Clin Immunol. 2017;179:40–6.
Article CAS PubMed Google Scholar
Chen Y, Zhang XS, Wang YG, Lu C, Li J, Zhang P. Imbalance of Th17 and Tregs in Thymoma may be a pathological mechanism of myasthenia gravis. Mol Immunol. 2021;133:67–76.
Article CAS PubMed Google Scholar
Cebi M, Cakar A, Erdogdu E, Durmus-Tekce H, Yegen G, Ozkan B, Parman Y, Saruhan-Direskeneli G. Thymoma patients with or without myasthenia gravis have increased Th17 cells, IL-17 production and ICOS expression. J Neuroimmunol. 2023;381:578129.
Article CAS PubMed Google Scholar
Gradolatto A, Nazzal D, Truffault F, Bismuth J, Fadel E, Foti M, Berrih-Aknin S. Both Treg cells and tconv cells are defective in the Myasthenia gravis thymus: roles of IL-17 and TNF-alpha. J Autoimmun. 2014;52:53–63.
Article CAS PubMed Google Scholar
Villegas JA, Bayer AC, Ider K, Bismuth J, Truffault F, Roussin R, Santelmo N, Le Panse R, Berrih-Aknin S, Dragin N. Il-23/Th17 cell pathway: a promising target to alleviate thymic inflammation maintenance in myasthenia gravis. J Autoimmun. 2019;98:59–73.
Article CAS PubMed Google Scholar
Masoud GN, Li W. HIF-1alpha pathway: role, regulation and intervention for cancer therapy. Acta Pharm Sin B. 2015;5:378–89.
Article PubMed PubMed Central Google Scholar
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011;146:772–84.
Article CAS PubMed PubMed Central Google Scholar
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, et al. The 2021 WHO classification of tumors of the Thymus and Mediastinum: what is New in Thymic Epithelial, Germ Cell, and mesenchymal tumors? J Thorac Oncol. 2022;17:200–13.
Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hoff MJ, Moorman AF. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res. 2009;37:e45.
Article CAS PubMed PubMed Central Google Scholar
Guo F, Wang CY, Wang S, Zhang J, Yan YJ, Guan ZY, Meng FJ. Alteration in gene expression profile of thymomas with or without myasthenia gravis linked with the nuclear factor-kappaB/autoimmune regulator pathway to myasthenia gravis pathogenesis. Thorac Cancer. 2019;10:564–70.
Article CAS PubMed PubMed Central Google Scholar
Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40:294–309.
Article CAS PubMed PubMed Central Google Scholar
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem. 2004;279:38458–65.
Article CAS PubMed Google Scholar
Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med. 2004;36:1–12.
Capone A, Volpe E. Transcriptional regulators of T Helper 17 cell differentiation in Health and Autoimmune diseases. Front Immunol. 2020;11:348.
Article CAS PubMed PubMed Central Google Scholar
Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Filì L, Ferri S, Frosali F, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007;204:1849–61.
Article CAS PubMed PubMed Central Google Scholar
Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY. An essential role for the IL-2 receptor in T(reg) cell function. Nat Immunol. 2016;17:1322–33.
Article CAS PubMed PubMed Central Google Scholar
Gilhus NE. Myasthenia Gravis. N Engl J Med. 2016;375:2570–81.
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