Adefegha SA, Oboh G, Okeke BM (2021) Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine. J Complement Integr Med 18:491–497

Article  CAS  PubMed  Google Scholar 

Allameh H, Fatemi I, Malayeri AR, Nesari A, Mehrzadi S, Goudarzi M (2020) Pretreatment with berberine protects against cisplatin-induced renal injury in male Wistar rats. Naunyn-Schmiedeberg’s Archives Pharmacol 393:1825–1833

Article  CAS  Google Scholar 

Bektas A, Schurman SH, Franceschi C, Ferrucci L (2020) A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging? Immun Ageing 17:23

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benzie IFF, Strain JJ (1996) The Ferric Reducing Ability of Plasma (FRAP) as a measure of antioxidant power: the FRAP Assay. Anal Biochem 239:70–76

Article  CAS  PubMed  Google Scholar 

Bonnard C, Durand A, Peyrol S, Chanseaume E, Chauvin M-A, Morio B, Vidal H, Rieusset J (2008) Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 118(2):789–800

CAS  PubMed  PubMed Central  Google Scholar 

Bonomini F, Rodella LF, Rezzani R (2015) Metabolic syndrome, aging and involvement of oxidative stress. Aging Disease 6:109

Article  PubMed  PubMed Central  Google Scholar 

Chen C-C, Hung T-H, Lee CY, Wang L-F, Wu C-H, Ke C-H, Chen S-F (2014) Berberine protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in traumatic brain Injury. PLoS ONE 9, e115694

Article  PubMed  PubMed Central  Google Scholar 

Dadgostar E, Moghanlou M, Parvaresh M, Mohammadi S, Khandan M, Aschner M, Mirzaei H, Tamtaji OR (2022) Can Berberine Serve as a New Therapy for Parkinson’s Disease? Neurotox Res 40:1096–1102

Article  PubMed  Google Scholar 

El-Horany HE-S, Gaballah HH, Helal DS (2018) Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. Arch Physiol Biochem 126:157–165

Article  PubMed  Google Scholar 

El-Shiekh RA, Ashour RM, El-Haleim A, Ahmed EA, Abdel-Sattar KA, E (2020) Hibiscus sabdariffa L.: a potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice. Biomed Pharmacother 128:110303

Article  CAS  PubMed  Google Scholar 

Esterbauer H, Cheeseman KH (1990) [42] determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal, in: methods in Enzymology. Elsevier, pp 407–421

Google Scholar 

Fang X, Wu H, Wei J, Miao R, Zhang Y, Tian J (2022) Research progress on the pharmacological effects of berberine targeting mitochondria. Front Endocrinol 13:982145

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM (2019) Chronic inflammation in the etiology of disease across the life span. Nat Med 25:1822–1832

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garg G, Singh S, Singh AK, Rizvi SI (2017) Antiaging Effect of Metformin on Brain in naturally aged and accelerated Senescence Model of Rat. Rejuven Res 20:173–182

Article  CAS  Google Scholar 

Gendy AM, Soubh A, Elnagar MR, Hamza E, Ahmed KA, Aglan A, El-Haddad AE, Farag MA, El-Sadek HM (2023) New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling. Food Chem Toxicol 175:113721

Article  CAS  PubMed  Google Scholar 

Glancy B, Balaban RS (2012) Role of mitochondrial Ca2+ in the regulation of Cellular energetics. Biochemistry 51:2959–2973

Article  CAS  PubMed  Google Scholar 

Gupta P, Gupta H, Tripathi S, Poluri KM (2023) Biochemical and metabolomic insights into antifungal mechanism of berberine against Candida Glabrata. Appl Microbiol Biotechnol 107:6085–6102

Article  CAS  PubMed  Google Scholar 

Hadzi-Petrushev N, Stojkovski V, Mitrov D, Mladenov M (2014) d-galactose induced inflammation lipid peroxidation and platelet activation in rats. Cytokine 69:150–153

Article  CAS  PubMed  Google Scholar 

Hussien HM, Abd-Elmegied A, Ghareeb DA, Hafez HS, Ahmed HEA, El-moneam NA (2018) Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer’s-like disease in rats. Food Chem Toxicol 111:432–444

Article  CAS  PubMed  Google Scholar 

Ji Z-H, Liu C, Zhao H, Yu X-Y (2014) Neuroprotective effect of Biatractylenolide against Memory Impairment in d-Galactose-induced aging mice. J Mol Neurosci 55:678–683

Article  PubMed  Google Scholar 

Kulkarni SK, Dhir A (2010) Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res 24:317–324

Article  CAS  PubMed  Google Scholar 

Kumar R, Kumar M, Rizvi SI (2021) Chitosan displays a potent caloric restriction Mimetic Effect in senescent rats. Rejuven Res 24:390–396

Article  CAS  Google Scholar 

Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A-G, Ahn B-W, Shaltiel S, Stadtman ER (1990) [49] determination of carbonyl content in oxidatively modified proteins. Methods in Enzymology. Elsevier, pp 464–478

Google Scholar 

Li PA, Hou X, Hao S (2017) Mitochondrial biogenesis in neurodegeneration. J Neurosci Res 95:2025–2029

Article  CAS  PubMed  Google Scholar 

Li F, Huang H, Wu Y, Lu Z, Zhou X, Tan F, Zhao X (2021) Lactobacillus fermentum HFY06 attenuates d-galactose-induced oxidative stress and inflammation in male Kunming mice. Food Funct 12:12479–12489

Article  CAS  PubMed  Google Scholar 

Liu B, Xie Y, Chen J, Xue J, Zhang X, Zhao M, Jia X, Wang Y, Qin S (2021) Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging mice. J Inflamm Res Volume 14:5541–5550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Chen H, Yu T, Fu X, Qian C, Feng X (2023) Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice. Aging 15:2705–2720

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J (2007) d-Galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8:373–381

Article  CAS  PubMed  Google Scholar 

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) Hallm Aging. Cell 153:1194–1217

Article  PubMed  PubMed Central  Google Scholar 

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2023) Hallmarks of aging: an expanding universe. Cell 186:243–278

Article  PubMed  Google Scholar 

Lu D-Y, Tang C-H, Chen Y-H, Wei I-H (2010) Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia. J Cell Biochem 110:697–705

Article  CAS  PubMed  Google Scholar 

Luo H, Kou T, Su Y, Shen Y, Yin L (2023) Experimental research on the evaluation of left ventricular systolic function by layered speckle tracking before and after berberine treatment in a cardiac hypertrophy rat model. Cardiovasc Diagnosis Therapy 13:367–383

Article  PubMed  PubMed Central  Google Scholar 

Ma X, Jiang Y, Wu A, Chen X, Pi R, Liu M, Liu Y (2010) Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. PLoS ONE 5:13489

Article  PubMed  PubMed Central  Google Scholar 

Munkhzul C, Yi SS, Kim J, Lee S, Kim H, Moon J-S, Lee M (2023) The microRNA-mediated gene regulatory network in the hippocampus and hypothalamus of the aging mouse. PLoS ONE 18, 0291943

Article  CAS  PubMed  PubMed Central  Google Scholar 

Navarro A, Gómez C, Sánchez-Pino M-J, González H, Bández MJ, Boveris AD, Boveris A (2005) Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Am J Physiol-Regul Integr Comp Physiol 289:R1392–R1399

Article  CAS  PubMed  Google Scholar 

Okoro NO, Odiba AS, Osadebe PO, Omeje EO, Liao G, Fang W, Jin C, Wang B (2021) Bioactive phytochemicals with anti-aging and Lifespan extending potentials in Caenorhabditis elegans. Molecules 26:7323

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pantiya P, Thonusin C, Ongnok B, Chunchai T, Kongkaew A, Nawara W, Arunsak B, Chattipakorn N, Chattipakorn SC (2023) Chronic D-galactose administration induces natural aging characteristics, in rat’s brain and heart. Toxicology 492:153553

Article  CAS  PubMed  Google Scholar 

Paradies G, Petrosillo G, Paradies V, Ruggiero FM (2011) Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin. Neurochem Int 58:447–457

Article