High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists

Burnet, F. The clonal selection theory of acquired immunity (Nashville, TN: Vanderbilt University Press., 1959).

Zinkernagel, R. M. Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes. Nature 251, 230–233 (1974).

Article  CAS  PubMed  Google Scholar 

Cunningham, A. J. & Lafferty, K. J. A simple conservative explanation of the H-2 restriction of interactions between lymphocytes. Scand. J. Immunol. 6, 1–6 (1977).

Article  CAS  PubMed  Google Scholar 

Linsley, P. S., Clark, E. A. & Ledbetter, J. A. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl Acad. Sci. USA 87, 5031–5035 (1990).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matzinger, P. Tolerance, danger, and the extended family. Annu Rev. Immunol. 12, 991–1045 (1994).

Article  CAS  PubMed  Google Scholar 

Janeway, C. A. Jr., Goodnow, C. C. & Medzhitov, R. Danger - pathogen on the premises! Immunological tolerance. Curr. Biol. 6, 519–522 (1996).

Article  CAS  PubMed  Google Scholar 

Curtsinger, J. M. et al. Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J. Immunol. 162, 3256–3262 (1999).

Article  CAS  PubMed  Google Scholar 

Corthay, A. A three-cell model for activation of naive T helper cells. Scand. J. Immunol. 64, 93–96 (2006).

Article  CAS  PubMed  Google Scholar 

Cella, M., Engering, A., Pinet, V., Pieters, J. & Lanzavecchia, A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388, 782–787 (1997).

Article  CAS  PubMed  Google Scholar 

Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394–397 (1997).

Article  CAS  PubMed  Google Scholar 

Blander, J. M. & Medzhitov, R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808–812 (2006).

Article  CAS  PubMed  Google Scholar 

Hanel, G., Angerer, C., Petry, K., Lichtenegger, F. S. & Subklewe, M. Blood DCs activated with R848 and poly(I:C) induce antigen-specific immune responses against viral and tumor-associated antigens. Cancer Immunol. Immunother. 71, 1705–1718 (2022).

Article  PubMed  Google Scholar 

Pulendran, B., P, S. A. & O’Hagan, D. T. Emerging concepts in the science of vaccine adjuvants. Nat. Rev. Drug Discov. 20, 454–475 (2021).

Sartorius, R., Trovato, M., Manco, R., D’Apice, L. & De Berardinis, P. Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines. NPJ Vaccines 6, 127 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez-Herrero, E., Lanier, O. L., Krishnan, N., D’Andrea, A. & Peppas, N. A. Drug delivery methods for cancer immunotherapy. Drug Deliv. Transl. Res. 14, 30–61 (2024).

Article  PubMed  Google Scholar 

Scott, P., Natovitz, P., Coffman, R. L., Pearce, E. & Sher, A. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168, 1675–1684 (1988).

Article  CAS  PubMed  Google Scholar 

Ossendorp, F., Mengede, E., Camps, M., Filius, R. & Melief, C. J. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med. 187, 693–702 (1998).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin, Z. & Blankenstein, T. CD4+ T cell–mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity 12, 677–686 (2000).

Article  CAS  PubMed  Google Scholar 

Corthay, A. et al. Primary antitumor immune response mediated by CD4+ T cells. Immunity 22, 371–383 (2005).

Article  CAS  PubMed  Google Scholar 

Scott, P. IL-12: initiation cytokine for cell-mediated immunity. Science 260, 496–497 (1993).

Article  CAS  PubMed  Google Scholar 

Hsieh, C. S. et al. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547–549 (1993).

Article  CAS  PubMed  Google Scholar 

Kobayashi, M. et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170, 827–845 (1989).

Article  CAS  PubMed  Google Scholar 

Rogge, L. et al. Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J. Immunol. 162, 3926–3932 (1999).

Article  CAS  PubMed  Google Scholar 

Ma, X. et al. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183, 147–157 (1996).

Article  CAS  PubMed  Google Scholar 

Laderach, D., Compagno, D., Danos, O., Vainchenker, W. & Galy, A. RNA interference shows critical requirement for NF-kappa B p50 in the production of IL-12 by human dendritic cells. J. Immunol. 171, 1750–1757 (2003).

Article  CAS  PubMed  Google Scholar 

Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F. & Lanzavecchia, A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6, 769–776 (2005).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goriely, S. et al. Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood 107, 1078–1084 (2006).

Article  CAS  PubMed  Google Scholar 

Zhu, Q. et al. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines. Proc. Natl Acad. Sci. USA 105, 16260–16265 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolf, S. F. et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146, 3074–3081 (1991).

Article  CAS  PubMed  Google Scholar 

Snijders, A. et al. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156, 1207–1212 (1996).

Article  CAS  PubMed  Google Scholar 

Becker, C. et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J. Clin. Invest. 112, 693–706 (2003).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Janeway, C. A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).

Article  CAS  PubMed  Google Scholar 

Fitzgerald, K. A. & Kagan, J. C. Toll-like Receptors and the Control of Immunity. Cell 180, 1044–1066 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Del Fresno, C., Iborra, S., Saz-Leal, P., Martinez-Lopez, M. & Sancho, D. Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation. Front. Immunol. 9, 804 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Girardin, S. E. et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300, 1584–1587 (2003).

Article  CAS  PubMed  Google Scholar 

Girardin, S. E. et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869–8872 (2003).

Article  CAS  PubMed  Google Scholar 

Almeida-da-Silva, C. L. C., Savio, L. E. B., Coutinho-Silva, R. & Ojcius, D. M. The role of NOD-like receptors in innate immunity. Front. Immunol. 14, 1122586 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rehwinkel, J. & Gack, M. U. RIG-I-like receptors: their regulation and roles in RNA sensing. Nat. Rev. Immunol. 20, 537–551 (2020).

Article  CAS  PubMed 

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