Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies

Li, X. et al. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct. Target Ther. 8, 239 (2023).

Article  PubMed  PubMed Central  Google Scholar 

United Nations. Department of Economic and Social Affairs, Population Division (2019). World Population Ageing 2019: Highlights (ST/ESA/SER.A/430) (2022).

Gralinski, L. E. & Menachery, V. D. Return of the Coronavirus: 2019-nCoV. Viruses 12, 135 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Koff, W. C. et al. Accelerating next-generation vaccine development for global disease prevention. Science 340, 1232910 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Mascola, J. R. & Fauci, A. S. Novel vaccine technologies for the 21st century. Nat. Rev. Immunol. 20, 87–88 (2020).

Article  CAS  PubMed  Google Scholar 

Hou, Y. et al. Advanced subunit vaccine delivery technologies: from vaccine cascade obstacles to design strategies. Acta Pharm. Sin. B 13, 3321–3338 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunningham, A. L., McIntyre, P., Subbarao, K., Booy, R. & Levin, M. J. Vaccines for older adults. BMJ 372, n188 (2021).

Article  PubMed  Google Scholar 

Bell, M. R. & Kutzler, M. A. An old problem with new solutions: strategies to improve vaccine efficacy in the elderly. Adv. Drug Deliv. Rev. 183, 114175 (2022).

Article  CAS  PubMed  Google Scholar 

Osterholm, M. T. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect. Dis. 12, 36–44 (2012).

Article  PubMed  Google Scholar 

Walford, R. L. The immunologic theory of aging. Gerontologist 4, 195–197 (1964).

Article  CAS  PubMed  Google Scholar 

Willyard, C. How anti-ageing drugs could boost COVID vaccines in older people. Nature 586, 352–354 (2020).

Article  CAS  PubMed  Google Scholar 

Qin, X., Jian, D. & Yi, C. Role of CD8+ T lymphocyte cells: interplay with stromal cells in tumor microenvironment. Acta Pharm. Sin. B 11, 1365–1378 (2021).

Article  Google Scholar 

Riese, P. et al. Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly. Nat. Commun. 13, 6894 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roukens, A. H. et al. Elderly subjects have a delayed antibody response and prolonged viraemia following yellow fever vaccination: a prospective controlled cohort study. PloS One 6, e27753 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schulz, A. R. et al. Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans. J. Immunol. 195, 4699–4711 (2015).

Article  CAS  PubMed  Google Scholar 

Ding, Y., Li, Z., Jaklenec, A. & Hu, Q. Vaccine delivery systems toward lymph nodes. Adv. Drug Deliv. Rev. 179, 113914 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lefebvre, J. S., Masters, A. R., Hopkins, J. W. & Haynes, L. Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses. Sci. Rep. 6, 25051 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, J., Deng, J. C. & Goldstein, D. R. How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions. Trends Mol. Med. 28, 1100–1111 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadamitzky, C. et al. Age-dependent histoarchitectural changes in human lymph nodes: an underestimated process with clinical relevance? J. Anat. 216, 556–562 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Agrawal, A. et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 178, 6912–6922 (2007).

Article  CAS  PubMed  Google Scholar 

Yang, Y., Guo, X., Hu, B., He, P. & Feng, M. Generated SecPen_NY-ESO-1_ubiquitin-pulsed dendritic cell cancer vaccine elicits stronger and specific T cell immune responses. Acta Pharm. Sin. B 11, 476–487 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Eisenbarth, S. C. Dendritic cell subsets in T cell programming: location dictates function. Nat. Rev. Immunol. 19, 89–103 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heath, W. R., Kato, Y., Steiner, T. M. & Caminschi, I. Antigen presentation by dendritic cells for B cell activation. Curr. Opin. Immunol. 58, 44–52 (2019).

Article  CAS  PubMed  Google Scholar 

Wang, J., Geiger, H. & Rudolph, K. L. Immunoaging induced by hematopoietic stem cell aging. Curr. Opin. Immunol. 23, 532–536 (2011).

Article  CAS  PubMed  Google Scholar 

Panda, A. et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J. Immunol. 184, 2518–2527 (2010).

Article  CAS  PubMed  Google Scholar 

Leleux, J., Atalis, A. & Roy, K. Engineering immunity: modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy. J. Control. Release 219, 610–621 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jackaman, C. et al. Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice. Aging Cell 12, 345–357 (2013).

Article  CAS  PubMed  Google Scholar 

Prieto, L. I. et al. Senescent alveolar macrophages promote early-stage lung tumorigenesis. Cancer Cell 41, 1261–1275.e6 (2023).

Article  CAS  PubMed  Google Scholar 

Wang, J., Yang, J. & Kopecek, J. Nanomedicines in B cell-targeting therapies. Acta Biomater. 137, 1–19 (2022).

Article  PubMed  Google Scholar 

Frasca, D. & Blomberg, B. B. Aging affects human B cell responses. J. Clin. Immunol. 31, 430–435 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Pritz, T. et al. Plasma cell numbers decrease in bone marrow of old patients. Eur. J. Immunol. 45, 738–746 (2015).

Article  CAS  PubMed  Google Scholar 

Cancro, M. P. Age-associated B cells. Annu. Rev. Immunol. 38, 315–340 (2020).

Article  CAS  PubMed  Google Scholar 

Yam-Puc, J. C. et al. Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade. Nat. Commun. 14, 3292 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen, C. D. et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat. Immunol. 5, 943–952 (2004).

Article  CAS  PubMed  Google Scholar 

Wols, H. A. et al. Migration of immature and mature B cells in the aged microenvironment. Immunology 129, 278–290 (2010).

Article  PubMed  Google Scholar 

Frasca, D., Blomberg, B. B., Garcia, D., Keilich, S. R. & Haynes, L. Age-related factors that affect B cell responses to vaccination in mice and humans. Immunol. Rev. 296, 142–154 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lefebvre, J. S. et al. The aged microenvironment contributes to the age‐related functional defects of CD4 T cells in mice. Aging Cell 11, 732–740 (2012).

Article  CAS  PubMed  Google Scholar 

Silva-Cayetano, A. et al. Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging. Nat. Immunol. 24, 1124–1137 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif