Toxoplasma gondii suppresses proliferation and migration of breast cancer cells by regulating their transcriptome

Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet (London, England). 2004;363(9425):1965–76.

Article  CAS  PubMed  Google Scholar 

Saeij JP, Boyle JP, Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 2005;21(10):476–81.

Article  PubMed  Google Scholar 

Hosseini SA, Amouei A, Sharif M, Sarvi S, Galal L, Javidnia J, Pagheh AS, Gholami S, Mizani A, Daryani A. Human toxoplasmosis: a systematic review for genetic diversity of Toxoplasma gondii in clinical samples. Epidemiol Infect. 2018;147:1–9.

Google Scholar 

Bigna JJ, Tochie JN, Tounouga DN, Bekolo AO, Ymele NS, Youda EL, Sime PS, Nansseu JR. Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis. Sci Rep. 2020;10(1):12102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marín-García PJ, Planas N, Llobat L. Toxoplasma gondii in foods: prevalence, control, and safety. Foods (Basel, Switzerland). 2022;11:16.

Google Scholar 

Milne GC, Webster JP, Walker M. Is the incidence of congenital toxoplasmosis declining? Trends Parasitol. 2023;39(1):26–37.

Article  CAS  PubMed  Google Scholar 

Megli CJ, Coyne CB. Infections at the maternal-fetal interface: an overview of pathogenesis and defence. Nat Rev Microbiol. 2022;20(2):67–82.

Article  CAS  PubMed  Google Scholar 

Robert-Gangneux F, Dardé ML. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev. 2012;25(2):264–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye HM, Lu MJ, Liu Q, Lin Y, Tang LY, Ren ZF. Beneficial Effect of Toxoplasma gondii Infection on the Prognosis of Breast Cancer Was Modified by Cytokines. Clin Epidemiol. 2023;15:469–81.

Article  PubMed  PubMed Central  Google Scholar 

Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ. Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Can Res. 2013;73(13):3842–51.

Article  CAS  Google Scholar 

Sanders KL, Fox BA, Bzik DJ. Attenuated Toxoplasma gondii stimulates immunity to pancreatic cancer by manipulation of myeloid cell populations. Cancer Immunol Res. 2015;3(8):891–901.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu LQ, Yao LJ, Jiang D, Zhou LJ, Chen M, Liao WZ, Zou WH, Peng HJ. A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis. Parasit Vectors. 2021;14(1):601.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu G, Zhou J, Zhao YH, Li QL, Gao YY, Wang L. Transcriptome sequencing investigated the tumor-related factors changes after T. gondii Infection. Front Microbiol. 2019;10:181.

Article  PubMed  PubMed Central  Google Scholar 

Fackenthal JD, Olopade OI. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer. 2007;7(12):937–48.

Article  CAS  PubMed  Google Scholar 

Wang X, Spandidos A, Wang H, Seed B: PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic acids research 2012, 40(Database issue):D1144–1149.

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif). 2001;25(4):402–8.

Article  CAS  PubMed  Google Scholar 

Chen S, Zhou Y, Chen Y, Gu J. fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics (Oxford, England). 2018;34(17):i884–90.

PubMed  Google Scholar 

Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9(4):357–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12(4):357–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gajria B, Bahl A, Brestelli J, Dommer J, Fischer S, Gao X, Heiges M, Iodice J, Kissinger JC, Mackey AJ, et al. ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res. 2008;36(11):D553-556.

CAS  PubMed  Google Scholar 

Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods. 2008;5(7):621–8.

Article  CAS  PubMed  Google Scholar 

Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform. 2011;12:323.

Article  CAS  Google Scholar 

Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.

Article  PubMed  PubMed Central  Google Scholar 

Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y et al: The genome sequence archive family: toward explosive data growth and diverse data types. Genomics Proteom Bioinform 2021.

Database Resources of the National Genomics Data Center. China National Center for Bioinformation in 2023. Nucleic Acids Res. 2023;51(D1):D18-d28.

Article  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Győrffy B. Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput Struct Biotechnol J. 2021;19:4101–9.

Article  PubMed  PubMed Central  Google Scholar 

Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA. Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol. 2010;11(2):174–83.

Article  CAS  PubMed  Google Scholar 

Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jing P, Bin Y, Wei-Hua W, Pu G. Effect of culture supernatant of Toxoplasma gondii on proliferation and apoptosis of human breast cancer cell line MCF-7. Chin J Zoon. 2009;25(8):768–71.

Google Scholar 

Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, et al. The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical analysis in breast cancer cell lines. Breast Cancer. 2010;4:35–41.

PubMed  PubMed Central  Google Scholar 

Wu X, Sun L, Zhang L, Liu ZQ, Luo Q, Zhang LX. Impact of Toxoplasma gondii on the proliferation and apoptosis of tumor cell lines. Chin J Parasitol Paras Dis. 2012;30(2):157–9.

Google Scholar 

Jian G. YE Bin, WU Wei-Hua, Jing K: Effects of Toxoplasma gondii tachyzoites on proliferation and cell cycle of mouse colon cancer cells ct26. Chin J Zoon. 2010;26(12):1088–92.

Google Scholar 

Bougen-Zhukov N, Decourtye-Espiard L, Mitchell W, Redpath K, Perkinson J, Godwin T, Black MA, Guilford P. E-cadherin-deficient cells are sensitive to the multikinase inhibitor dasatinib. Cancers. 2022;14:7.

Article  Google Scholar 

Edechi CA, Amini M, Hamedani MK, Terceiro LEL, Nickel BE, Leygue E, Myal Y. Comparison of fixation methods for the detection of claudin 1 and E-cadherin in breast cancer cell lines by immunofluorescence. J Histochem Cytochem. 2022;70(2):181–7.

Article  CAS  PubMed  Google Scholar 

Chen J, Liao W, Peng H. Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth. Front Cell Infect Microbiol. 2022;12: 959300.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pyo KH, Lee YW, Lim SM, Shin EH. Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice. Oncotarget. 2016;7(45):74107–19.

Article  PubMed  PubMed Central  Google Scholar 

Fox BA, Sanders KL, Rommereim LM, Guevara RB, Bzik DJ. Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii uracil auxotrophs controls the development of antitumor immunity. PLoS Genet. 2016;12(7): e1006189.

Article  PubMed  PubMed Central  Google Scholar 

Seo SH, Kim SG, Shin JH, Ham DW, Shin EH. Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells. Int J Mol Sci. 2020;21:18.

Article  Google Scholar 

Pittman KJ, Aliota MT, Knoll LJ. Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection. BMC Genomics. 2014;15(1):806.

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