Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130:769–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou G-B, Chen S-J, Wang Z-Y, Chen Z. Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo. Cell Res. 2007;17:274–6.

Article  CAS  PubMed  Google Scholar 

Wang J, Wong Y-K, Liao F. What has traditional Chinese medicine delivered for modern medicine? Expert Rev Mol Med. 2018;20:e4.

Article  PubMed  Google Scholar 

Tao X, Lipsky PE. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium Wilfordii Hook F. Rheum Dis Clin North Am. 2000;26:29–50, viii.

Article  CAS  PubMed  Google Scholar 

Luo H, Vong CT, Chen H, Gao Y, Lyu P, Qiu L, et al. Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine. Chin Med. 2019;14:48.

Article  PubMed  PubMed Central  Google Scholar 

Gao J, Zhang Y, Liu X, Wu X, Huang L, Gao W. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics. 2021;11:7199–221.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei J, Yan Y, Chen X, Qian L. The roles of plant-derived triptolide on non-small cell lung cancer. Oncol Res. 2019;27:849–58.

Article  PubMed  PubMed Central  Google Scholar 

Zheng Y, Zhang W-J, Wang X-M. Triptolide with potential medicinal value for diseases of the central nervous system. CNS Neurosci Ther. 2013;19:76–82.

Article  CAS  PubMed  Google Scholar 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–32.

Article  PubMed  Google Scholar 

Yan P, Sun X, Triptolide. A new star for treating human malignancies. J Cancer Res Ther. 2018;14:S271–5.

Article  CAS  PubMed  Google Scholar 

Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, et al. 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years. N Engl J Med. 2017;377:1836–46.

Article  PubMed  PubMed Central  Google Scholar 

Noel P, Von Hoff DD, Saluja AK, Velagapudi M, Borazanci E, Han H. Triptolide and its derivatives as cancer therapies. Trends Pharmacol Sci. 2019;40:327–41.

Article  CAS  PubMed  Google Scholar 

Zhou Z-L, Yang Y-X, Ding J, Li Y-C, Miao Z-H. Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep. 2012;29:457–75.

Article  CAS  PubMed  Google Scholar 

Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, Linstra R, van Vugt MATM. Genomic instability, inflammatory signaling and response to cancer immunotherapy. Biochim Biophys Acta Rev Cancer. 2022;1877:188661.

Article  CAS  PubMed  Google Scholar 

Tewari D, Bawari S, Sharma S, DeLiberto LK, Bishayee A. Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: a novel strategy for cancer prevention and therapy. Pharmacol Ther. 2021;227:107876.

Article  CAS  PubMed  Google Scholar 

Mao R, Xu S, Sun G, Yu Y, Zuo Z, Wang Y, et al. Triptolide injection reduces Alzheimer’s disease-like pathology in mice. Synapse. 2023;77:e22261.

Article  CAS  PubMed  Google Scholar 

Chen Q, Lei Y-Q, Liu J-F, Wang Z-C, Cao H. Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest. Aging. 2021;13:3031–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang R, Guo F, Li Y, Liang Y, Li G, Fu P, et al. Activation of AMPK by Triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis. Phytomedicine. 2021;92:153739.

Article  CAS  PubMed  Google Scholar 

Piao X, Zhou J, Xue L. Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and β-catenin signaling. Int Immunopharmacol. 2021;99:108010.

Article  CAS  PubMed  Google Scholar 

Fang W-Y, Tseng Y-T, Lee T-Y, Fu Y-C, Chang W-H, Lo W-W, et al. Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway. Br J Pharmacol. 2021;178:2998–3016.

Article  CAS  PubMed  Google Scholar 

Li P, Yang X, Yang Y, He H, Chou C-K, Chen F, et al. Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice. J Control Release. 2020;319:87–103.

Article  CAS  PubMed  Google Scholar 

Yu G-M, Zhou L-F, Zeng B-X, Huang J-J, She X-J. The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model. Redox Rep. 2021;26:197–202.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Ba X, Wang H, Shen P, Han L, Lin W et al. Triptolide alleviates collagen-induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN-STAT3 pathway. Basic Clin Pharmacol Toxicol. 2023.

Zhang Q, Liu J, Zhang M, Wei S, Li R, Gao Y, et al. Apoptosis induction of fibroblast-like synoviocytes is an important molecular-mechanism for herbal medicine along with its active components in treating rheumatoid arthritis. Biomolecules. 2019;9:795.

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Ye Y, Qiu Q, Xiao Y, Huang M, Shi M, et al. Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway. Int Immunopharmacol. 2016;41:8–16.

Article  PubMed  Google Scholar 

Wen J, Liu J, Wang X, Wang J. Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by down-regulating lncRNA ENST00000619282. Phytother Res. 2021;35:4334–46.

Article  CAS  PubMed  Google Scholar 

Tang B, Zhu J, Zhang B, Wu F, Wang Y, Weng Q, et al. Therapeutic potential of triptolide as an anti-inflammatory agent in dextran sulfate sodium-induced murine experimental colitis. Front Immunol. 2020;11:592084.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao X, Chen C, Yuan L. Triptolide attenuates neuropathic pain by regulating microglia polarization through the CCL2/CCR2 axis. Evid Based Complement Alternat Med. 2021;2021:8985721.

Article  PubMed  PubMed Central  Google Scholar 

Skopelja-Gardner S, Jones JD, Rigby WFC. NETtling the host: breaking of tolerance in chronic inflammation and chronic infection. J Autoimmun. 2018;88:1–10.

Article  CAS  PubMed  Google Scholar 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–5.

Article  CAS  PubMed  Google Scholar 

Lee KH, Kronbichler A, Park DD-Y, Park Y, Moon H, Kim H, et al. Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review. Autoimmun Rev. 2017;16:1160–73.

Article  CAS  PubMed  Google Scholar 

Guan H, Xie L, Ji Z, Song R, Qi J, Nie X. Triptolide inhibits neutrophil extracellular trap formation. Ann Transl Med. 2021;9:1384.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rao Q, Ma G-C, Wu H, Li M, Xu W, Wang G-J, et al. Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models. Drug Deliv. 2022;29:679–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wei J, Kong L, Song M, Zhang Y, Xiao X, et al. Network pharmacology, molecular docking and bioinformatics reveal the mechanism of Tripterygii Wilfordii against Osteosarcoma. Med (Baltim). 2022;101:e32389.

Article  CAS  Google Scholar 

Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249–57.

Article  CAS  PubMed  Google Scholar 

Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003;3:401–10.

Article