Aarsland D, Påhlhagen S, Ballard CG, Ehrt U, Svenningsson P. Depression in Parkinson disease–epidemiology, mechanisms and management. Nat Rev Neurol. 2011;8(1):35–47. https://doi.org/10.1038/nrneurol.2011.189.

Article  CAS  PubMed  Google Scholar 

Bennett BD, Wilson CJ. Spontaneous activity of neostriatal cholinergic interneurons in vitro. J Neurosci. 1999;19(13):5586–96. https://doi.org/10.1523/jneurosci.19-13-05586.1999.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bondarenko V, Wells MM, Chen Q, Tillman TS, Singewald K, Lawless MJ, Tang P. Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor. Nat Commun. 2022;13(1):793. https://doi.org/10.1038/s41467-022-28400-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bortolato M, Yardley MM, Khoja S, Godar SC, Asatryan L, Finn DA, Davies DL. Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. Int J Neuropsychopharmacol. 2013;16(5):1059–70. https://doi.org/10.1017/s1461145712000909.

Article  CAS  PubMed  Google Scholar 

Britt JP, McGehee DS. Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens. J Neurosci. 2008;28(7):1672–81. https://doi.org/10.1523/jneurosci.4275-07.2008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown MT, Tan KR, O’Connor EC, Nikonenko I, Muller D, Lüscher C. Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning. Nature. 2012;492(7429):452–6. https://doi.org/10.1038/nature11657.

Article  CAS  PubMed  Google Scholar 

Brundage JN, Mason CP, Wadsworth HA, Finuf CS, Nelson JJ, Ronström PJW, Yorgason JT. Regional and sex differences in spontaneous striatal dopamine transmission. J Neurochem. 2022;160(6):598–612. https://doi.org/10.1111/jnc.15473.

Article  CAS  PubMed  Google Scholar 

Chinta SJ, Andersen JK. Dopaminergic neurons. Int J Biochem Cell Biol. 2005;37(5):942–6. https://doi.org/10.1016/j.biocel.2004.09.009.

Article  CAS  PubMed  Google Scholar 

Coddou C, Stojilkovic SS, Huidobro-Toro JP. Allosteric modulation of ATP-gated P2X receptor channels. Rev Neurosci. 2011;22(3):335–54. https://doi.org/10.1515/rns.2011.014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collins T, Millar NS. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78(2):198–204. https://doi.org/10.1124/mol.110.064295.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Covey DP, Juliano SA, Garris PA. Amphetamine elicits opposing actions on readily releasable and reserve pools for dopamine. PLoS ONE. 2013;8(5): e60763. https://doi.org/10.1371/journal.pone.0060763.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crichlow EC, Mishra PR, Crawford RD. Anticonvulsant effects of ivermectin in genetically-epileptic chickens. Neuropharmacology. 1986;25(10):1085–8. https://doi.org/10.1016/0028-3908(86)90154-1.

Article  CAS  PubMed  Google Scholar 

Crump A, Ōmura S. Ivermectin, “wonder drug” from Japan: the human use perspective. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(2):13–28. https://doi.org/10.2183/pjab.87.13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, McKernan RM. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther. 2000;295(3):1051–60.

CAS  PubMed  Google Scholar 

Degani-Katzav N, Klein M, Har-Even M, Gortler R, Tobi R, Paas Y. Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization. Sci Rep. 2017;7:42481. https://doi.org/10.1038/srep42481.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diggs HE, Feller DJ, Crabbe JC, Merrill C, Farrell E. Effect of chronic ivermectin treatment on GABA receptor function in ethanol withdrawal-seizure prone and resistant mice. Lab Anim Sci. 1990;40(1):68–71.

CAS  PubMed  Google Scholar 

Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013;4(5):693–703. https://doi.org/10.1021/cn400026v.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fox LM. Ivermectin: uses and impact 20 years on. Curr Opin Infect Dis. 2006;19(6):588–93. https://doi.org/10.1097/QCO.0b013e328010774c.

Article  PubMed  Google Scholar 

Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL. P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Front Neurosci. 2014;8:176. https://doi.org/10.3389/fnins.2014.00176.

Article  PubMed  PubMed Central  Google Scholar 

Gao F, Chen D, Ma X, Sudweeks S, Yorgason JT, Gao M, Wu J. Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol. Neuropharmacology. 2019;149:45–54. https://doi.org/10.1016/j.neuropharm.2019.01.021.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gowtham S, Karthikeyan K. Wonder drug for worms: a review of three decades of ivermectin use in dermatology. Indian J Dermatol Venereol Leprol. 2019;85(6):674–8. https://doi.org/10.4103/ijdvl.IJDVL_840_18.

Article  PubMed  Google Scholar 

Gunning K, Pippitt K, Kiraly B, Sayler M. Pediculosis and scabies: treatment update. Am Fam Physician. 2012;86(6):535–41.

PubMed  Google Scholar 

Gómez AA, Shnitko TA, Barefoot HM, Brightbill EL, Sombers LA, Nicola SM, Robinson DL. Local μ-opioid receptor antagonism blunts evoked phasic dopamine release in the nucleus accumbens of rats. ACS Chem Neurosci. 2019;10(4):1935–40. https://doi.org/10.1021/acschemneuro.8b00437.

Article  CAS  Google Scholar 

Hoogland IC, Houbolt C, van Westerloo DJ, van Gool WA, van de Beek D. Systemic inflammation and microglial activation: systematic review of animal experiments. J Neuroinflammation. 2015;12:114. https://doi.org/10.1186/s12974-015-0332-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jelínková I, Yan Z, Liang Z, Moonat S, Teisinger J, Stojilkovic SS, Zemková H. Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation. Biochem Biophys Res Commun. 2006;349(2):619–25. https://doi.org/10.1016/j.bbrc.2006.08.084.

Article  CAS  PubMed  Google Scholar 

Kawaguchi Y. Neostriatal cell subtypes and their functional roles. Neurosci Res. 1997;27(1):1–8. https://doi.org/10.1016/s0168-0102(96)01134-0.

Article  CAS  PubMed  Google Scholar 

Kemp JM, Powell TP. The structure of the caudate nucleus of the cat: light and electron microscopy. Philos Trans R Soc Lond B Biol Sci. 1971;262(845):383–401. https://doi.org/10.1098/rstb.1971.0102.

Article  CAS  PubMed  Google Scholar 

Khoja S, Asatryan L, Jakowec MW, Davies DL. Dopamine receptor blockade attenuates purinergic p2x4 receptor-mediated prepulse inhibition deficits and underlying molecular mechanisms. Front Cell Neurosci. 2019;13:331. https://doi.org/10.3389/fncel.2019.00331.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khoja S, Huynh N, Warnecke AMP, Asatryan L, Jakowec MW, Davies DL. Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders. Psychopharmacology. 2018;235(6):1697–709. https://doi.org/10.1007/s00213-018-4869-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khoja S, Shah V, Garcia D, Asatryan L, Jakowec MW, Davies DL. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016;139(1):134–48. https://doi.org/10.1111/jnc.13734.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura H, McGeer PL, Peng F, McGeer EG. Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry. Science. 1980;208(4447):1057–9. https://doi.org/10.1126/science.6990490.

Article  CAS  PubMed  Google Scholar 

Kircik LH, Del Rosso JQ, Layton AM, Schauber J. Over 25 years of clinical experience with ivermectin: an overview of safety for an increasing number of indications. J Drugs Dermatol. 2016;15(3):325–32.

PubMed  Google Scholar 

Kramer PF, Brill-Weil SG, Cummins AC, Zhang R, C