Ostrom QT, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the united states in 2014–2018. Neuro Oncol. 2021;23(12 Suppl 2):iii1–105.

Article  PubMed  PubMed Central  Google Scholar 

Haruwaka K, et al. Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun. 2019;10(1):5816.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stupp R, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–96.

Article  CAS  PubMed  Google Scholar 

Aldape K, et al. Challenges to curing primary brain tumours. Nat Rev Clin Oncol. 2019;16(8):509–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Louis D, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114(2):97–109.

Article  PubMed  PubMed Central  Google Scholar 

Seyfried TN, Shelton LM. Cancer as a metabolic disease. Nutr Metab. 2010;7:7.

Article  Google Scholar 

Martínez-Reyes I, Chandel N. Cancer metabolism: looking forward. Nat Rev Cancer. 2021;21(10):669–80.

Article  PubMed  Google Scholar 

Shi R, Tang Y, Miao H. Metabolism in tumor microenvironment: Implications for cancer immunotherapy. MedComm. 2020;1(1):47–68.

Article  PubMed  PubMed Central  Google Scholar 

Poff A, et al. Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer. Int J Cancer. 2014;135(7):1711–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menendez JA, et al. The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells. Cell Cycle. 2013;12(8):1166–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ransohoff R, Engelhardt B. The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol. 2012;12(9):623–35.

Article  CAS  PubMed  Google Scholar 

Graeber M, Scheithauer B, Kreutzberg G. Microglia in brain tumors. Glia. 2002;40(2):252–9.

Article  PubMed  Google Scholar 

Ginhoux F, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330(6005):841–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badie B, Schartner J. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery. 2000;46(4):957–61.

CAS  PubMed  Google Scholar 

Razavi S, et al. Immune evasion strategies of glioblastoma. Front Surg. 2016;3:11.

Article  PubMed  PubMed Central  Google Scholar 

Hambardzumyan D, Gutmann D, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci. 2016;19(1):20–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aguzzi A, Barres BA, Bennett ML. Microglia: scapegoat, saboteur, or something else? Science. 2013;339(6116):156–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ginhoux F, Guilliams M. Tissue-resident macrophage ontogeny and homeostasis. Immunity. 2016;44(3):439–49.

Article  CAS  PubMed  Google Scholar 

Prinz M, Erny D, Hagemeyer N. Ontogeny and homeostasis of CNS myeloid cells. Nat Immunol. 2017;18(4):385–92.

Article  CAS  PubMed  Google Scholar 

Goldmann T, et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol. 2016;17(7):797–805.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowman RL, et al. Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies. Cell Rep. 2016;17(9):2445–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murray PJ, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shapouri-Moghaddam A, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425–40.

Article  CAS  PubMed  Google Scholar 

Mantovani A, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25(12):677–86.

Article  CAS  PubMed  Google Scholar 

Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Investig. 2012;122(3):787–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biswas SK, Mantovani A. Orchestration of metabolism by macrophages. Cell Metab. 2012;15(4):432–7.

Article  CAS  PubMed  Google Scholar 

Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889–96.

Article  CAS  PubMed  Google Scholar 

Martinez FO, et al. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol. 2006;177(10):7303–11.

Article  CAS  PubMed  Google Scholar 

He Y, et al. IL-4 switches microglia/macrophage M1/M2 polarization and alleviates neurological damage by modulating the JAK1/STAT6 pathway following ICH. Neuroscience. 2020;437:161–71.

Article  CAS  PubMed  Google Scholar 

Tang Y, Le W. Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol. 2016;53(2):1181–94.

Article  CAS  PubMed  Google Scholar 

Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123–47.

Article  CAS  PubMed  Google Scholar 

Covarrubias A, Aksoylar H, Horng T. Control of macrophage metabolism and activation by mTOR and Akt signaling. Semin Immunol. 2015;27(4):286–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galván-Peña S, O’Neill L. Metabolic reprograming in macrophage polarization. Front Immunol. 2014;5:420.

PubMed  PubMed Central  Google Scholar 

Lackey D, Olefsky J. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016;12(1):15–28.

Article  CAS  PubMed  Google Scholar 

Orihuela R, McPherson C, Harry G. Microglial M1/M2 polarization and metabolic states. Br J Pharmacol. 2016;173(4):649–65.

Article  CAS  PubMed  Google Scholar 

Pan Y, et al. Tumor-associated macrophages in tumor immunity. Front Immunol. 2020;11:583084.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brubaker SW, et al. Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol. 2015;33:257–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abès R, et al. Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response. Blood. 2010;116(6):926–34.

Article  PubMed