Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol. 2023;21:133–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Q, Zheng B, Daines L, Sheikh A. Long-term sequelae of COVID-19: a systematic review and Meta-analysis of one-year Follow-Up studies on Post-COVID symptoms. Pathogens. 2022;11:269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Haupert SR, Zimmermann L, Shi X, Fritsche LG, Mukherjee B. Global prevalence of post-coronavirus disease 2019 (COVID-19) condition or long COVID: a meta-analysis and systematic review. J Infect Dis. 2022;226:1593–607.

Article  CAS  PubMed  Google Scholar 

Global Burden of Disease Long COVID Collaborators, Wulf Hanson S, Abbafati C, et al. Estimated global proportions of individuals with persistent fatigue, cognitive, and respiratory symptom clusters following symptomatic COVID-19 in 2020 and 2021. JAMA. 2022;328:1604–15.

Article  PubMed Central  Google Scholar 

World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. World Health Organization. https://apps.who.int/iris/handle/10665/345824. Lizenz: CC BY-NC-SA 3.0 IGO.

National Institute for Health and Care Excellence (NICE): COVID-19 rapide guideline: managing the long-term effects of COVID-19. 3. November 2022. https://www.nice.org.uk/guidance/ng188/resources/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742 (last accessed on April 3rd 2023).

Förster C, Colombo MG, Wetzel AJ, Martus P, Joos S. Persisting symptoms after COVID-19. Dtsch Arztebl Int. 2022;119:167–74.

PubMed  PubMed Central  Google Scholar 

Augustin M, Schommers P, Stecher M et al. Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Health Eur. 2021:100122.

Lackermair K, Wilhelm K, William F, et al. The prevalence of persistent symptoms after COVID-19 disease. Dtsch Arztebl Int. 2022;119:175–6.

PubMed  PubMed Central  Google Scholar 

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020;323:1239–42.

Parker AM, Brigham E, Connolly B, et al. Addressing the post-acute sequelae of SARS-CoV-2 infection: a multidisciplinary model of care. Lancet Respir Med. 2021;9:1328–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zawilska JB, Kuczyńska K. Psychiatric and neurological complications of long COVID. J Psychiatr Res. 2022;156:349–60.

Article  PubMed  PubMed Central  Google Scholar 

Yuan N, Lv ZH, Sun CR, Wen YY, Tao TY, Qian D, Tao FP, Yu JH. Post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors: a systematic review and meta-analysis. Front Public Health. 2023;11:1112383.

Article  PubMed  PubMed Central  Google Scholar 

Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep. 2021;11:16144.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourmistrova NW, Solomon T, Braude P, Strawbridge R, Carter B. Long-term effects of COVID-19 on mental health: a systematic review. J Affect Disord. 2022;299:118–25.

Article  CAS  PubMed  Google Scholar 

Renaud-Charest O, Lui LMW, Eskander S, Ceban F, Ho R, Di Vincenzo JD, Rosenblat JD, Lee Y, Subramaniapillai M, McIntyre RS. Onset and frequency of depression in post-COVID-19 syndrome: a systematic review. J Psychiatr Res. 2021;144:129–37.

Article  PubMed  PubMed Central  Google Scholar 

Stallmach A, Katzer K, Besteher B, et al. Mobile primary healthcare for post-COVID patients in rural areas: a proof-of-concept study. Infection. 2023;51:337–45.

Article  CAS  PubMed  Google Scholar 

Yunitri N, Chu H, Kang XL, Jen HJ, Pien LC, Tsai HT, Kamil AR, Chou KR. Global prevalence and associated risk factors of posttraumatic stress disorder during COVID-19 pandemic: a meta-analysis. Int J Nurs Stud. 2022;126:104136. https://doi.org/10.1016/j.ijnurstu.2021.104136.

Article  PubMed  Google Scholar 

Houben-Wilke S, Goërtz YM, Delbressine JM, Vaes AW, Meys R, Machado FV, van Herck M, Burtin C, Posthuma R, Franssen FM, Vijlbrief H, Spies Y, van ‘t Hul AJ, Spruit MA, Janssen DJ. The impact of long COVID-19 on Mental Health: Observational 6-Month Follow-Up study. JMIR Ment Health. 2022;9:e33704. https://doi.org/10.2196/33704.

Article  PubMed  PubMed Central  Google Scholar 

Janiri D, Carfì A, Kotzalidis GD, Bernabei R, Landi F, Sani G, Gemelli Against COVID-19 Post-Acute Care Study Group. Posttraumatic stress disorder in patients after severe COVID-19 infection. JAMA Psychiatry. 2021;78:567–9.

Article  PubMed  PubMed Central  Google Scholar 

Malik P, Patel K, Pinto C, Jaiswal R, Tirupathi R, Pillai S, Patel U. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis. J Med Virol. 2022;94:253–62.

Article  CAS  PubMed  Google Scholar 

Goßlau Y, Warm TD, Hernandez Cancino EF, Kirchberger I, Meisinger C, Linseisen J, Hyhlik-Duerr A. The prevalence of vascular complications in SARS-CoV-2 infected outpatients. Wien Med Wochenschr. 2023;173(7–8):168–72. https://doi.org/10.1007/s10354-022-00954-x.

Article  PubMed  Google Scholar 

Meisinger C, Kirchberger I, Warm TD, Hyhlik-Dürr A, Goßlau Y, Linseisen J. Elevated plasma D-dimer concentrations in adults after an outpatient-treated COVID-19 infection. Viruses. 2022;14:2441.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kirchberger I, Peilstöcker D, Warm TD, et al. Subjective and objective cognitive impairments in non-hospitalized persons 9 months after SARS-CoV-2 infection. Viruses. 2023;15:256.

Article  PubMed  PubMed Central  Google Scholar 

Löwe B, Spitzer R, Zipfel S, Herzog W. PHQ-D Manual. Komplettversion und Kurzform. Autorisierte deutsche Version des „Prime MD Patient Health Questionnaire (PHQ) [cited 26 Aug 2020]. In: PLOS Blogs. Heidelberg: 2002. Available from: https://www.klinikum.uni-heidelberg.de/fileadmin/Psychosomatische_Klinik/download/PHQ_Manual1.pdf.

Kroenke K, Spitzer RL, Williams JBW, Löwe B. The Patient Health Questionnaire somatic, anxiety, and depressive Symptom scales: a systematic review. Gen Hosp Psychiatry. 2010;32:345–59.

Article  PubMed  Google Scholar 

Manea L, Gilbody S, McMillan D. A diagnostic meta-analysis of the Patient Health Questionnaire-9 (PHQ-9) algorithm scoring method as a screen for depression. Gen Hosp Psychiatry. 2015;37:67–75.

Article  PubMed  Google Scholar 

Löwe B, Gräfe K, Quenter A, Zipfel S, Herzog W. Screening psychischer Störung Mit dem Gesundheitsfragebogen für Patienten (PHQD) Ergebnisse Der Deutschen Validierungsstudie. Diagnostica. 2004;50:171–81.

Article  Google Scholar 

Rosner R, Hagl M. Die revidierte impact of event-skala (IES-R). Psychosom Konsiliarpsychiatr. 2008;2:240–3.

Article  Google Scholar 

Michielsen HJ, De Vries J, Van Heck GL. Psychometric qualities of a brief self-rated fatigue measure the fatigue Assessment Scale. J Psychosom Res. 2003;54:345–52.

Article  PubMed  Google Scholar 

Mead G, Lynch J, Greig C, Young A, Lewis S, Sharpe M. Evaluation of fatigue scales in stroke patients. Stroke. 2007;38:2090–5.

Article  PubMed  Google Scholar 

Cumming TB, Mead G. Classifying post-stroke fatigue: optimal cut-off on the fatigue Assessment Scale. J Psychosom Res. 2017;103:147–9.

Article  PubMed  Google Scholar 

Hüppe M, Schneider K, Casser HR, Knille A, Kohlmann T, Lindena G, Nagel B, Nelles J, Pfingsten M, Petzke F. Kennwerte und teststatistische Güte Des Veterans RAND 12-Item Health Survey (VR-12) bei Patienten Mit Chronischem Schmerz: Eine Auswertung auf basis des KEDOQ-Schmerz-datensatzes. Der Schmerz. 2021;6:109–20.

Google Scholar 

Cohen J. Statistical Power Analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates,; 1988.

Google Scholar 

Gaspar P, Dias M, Parreira I, Gonçalves HD, Parlato F, Maione V, Atalaia Barbacena H, Carreiro C, Duarte L. Predictors of Long-COVID-19 and its impact on quality of life: longitudinal analysis at 3, 6 and 9 months after discharge from a Portuguese centre. Acta Med Port. 2023;24. https://doi.org/10.20344/amp.19047.

Bahmer T, Borzikowsky C, Lieb W, Horn A, Krist L, Fricke J, Scheibenbogen C, Rabe KF, Maetzler W, Maetzler C, Laudien M, Frank D, Ballhausen S, Hermes A, Miljukov O, Haeusler KG, Mokhtari NEE, Witzenrath M, Vehreschild JJ, Krefting D, Pape D, Montellano FA, Kohls M, Morbach C, Störk S, Reese JP, Keil T, Heuschmann P, Krawczak M, Schreiber S, NAPKON study group. Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: a prospective, multi-centre, population-based cohort study. EClinicalMedicine. 2022;51:101549.

Article  PubMed  PubMed Central  Google Scholar 

Goldberg X, Castaño-Vinyals G, Espinosa A, Carreras A, Liutsko L, Sicuri E, Foraster M, O’Callaghan-Gordo C, Dadvand P, Moncunill G, Dobaño C, Cortés B, Pleguezuelos V, Straif K, Garcia-Aymerich J, de Cid R, Cardis E, Kogevinas M. Mental health and COVID-19 in a general population cohort in Spain (COVICAT study). Soc Psychiatry Psychiatr Epidemiol. 2022;57:2457–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lemhöfer C, Sturm C, Loudovici-Krug D, Best N, Gutenbrunner C. The impact of Post-COVID-Syndrome on functioning - results from a community survey in patients after mild and moderate SARS-CoV-2-infections in Germany. J Occup Med Toxicol. 2021;16:45.

Article  PubMed  PubMed Central  Google Scholar 

Streit F, Zillich L, Frank J, Kleineidam L, Wagner M, Baune BT, Klinger-König J, Grabe HJ, Pabst A, Riedel-Heller SG, Schmiedek F, Schmidt B, Erhardt A, Deckert J, NAKO I, Rietschel M, Berger K. Lifetime and current depression in the German National Cohort (NAKO). World J Biol Psychiatry. 2023;24(10):865–80.

Article  PubMed  Google Scholar 

Premraj L, Kannapadi NV, Briggs J, Seal SM, Battaglini D, Fanning J, Suen J, Robba C, Fraser J, Cho SM. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis. J Neurol Sci. 2022;434:120162.

Article  CAS  PubMed  PubMed Central  Google Scholar