N6-methyladenosine-dependent signaling in colorectal cancer: functions and clinical potential

ARHGEF2

Rho/Rac guanine nucleotide exchange factor 2

AMPK

Adenosine 5‘-monophosphate-activated protein kinase

ASB6

Ankyrin repeat and SOCS box protein 6

ATP

Adenosine triphosphate

BHLHE41

Class E basic helix-loop-helix protein 41

CAND1

Cullin associated and neddylation dissociated 1

CRB3

Crumbs Cell Polarity Complex Component 3

CXCL1

C-X-C motif chemokine ligand 1

CXCR2

C-X-C Motif Chemokine Receptor 2

CTD

carboxy-terminal structural domain

CTC

Circulating tumor cell

CRISPR-Cas9

Clustered regularly interspaced short palindromic repeats

CAF

Cancer associated fibroblasts

EJCs,

Exon junction complexes EphA2, Ephrin type-A receptor 2

EGFR

Epidermal growth factor receptor

EMT,

Epithelial–mesenchymal transition

ELNPs

Exosome-Liposome Hybrid Nanoparticles

FTO

Fat mass and obesity‐associated protein

F. nucleatum

Fusobacterium nucleatum

G6PD

Glucose-6-phosphate dehydrogenase

GULT1

Glucose transporter protein-1

GSK3β

Glycogen synthase kinase 3 beta

GAS5

Growth arrest-specific 5

GMEB2

Glucocorticoid Modulatory Element Binding Protein 2

HNRNPA2B1

Heterogeneous Nuclear Ribonucleoprotein A2/B1

H3K4me3

Histone H3 lysine 4 tri-methylation

HMGA1

High mobility group box-1 protein

IGF2BP2

Insulin-like growth factor 2 mRNA-binding protein 2

IBD

Inflammatory bowel disease

KDM5C

Lysine Demethylase 5 C

LGR-5

Leucine-rich repeat-containing G-protein coupled receptor 5

LncZFAS1

Long non-coding RNA ZFAS1

LDHA

Lactate dehydrogenase A

MACOM

M6A-METTL associated complex

METTL3

Methyltransferase like 3

METTL16

Methyltransferase-like 16

METTL14

Methyltransferase-like 14

M2-TAMs

M2 tumor-associated macrophages

MAPK

Mitogen-activated protein kinase

MeRIP-seq

Methylated RNA immunoprecipitation sequencing

MDSCs

Myeloid-derived suppressor cells

MCT4

Monocarboxylate transporter 4

PHF20,

PHD Finger Protein 20

PI3K

Phosphoinositide 3-kinase

PCNA

Proliferating cell nuclear antigen

PGAM1

Phosphoglycerate Mutase 1

PDK4,

Pyruvate Dehydrogenase Kinase 4

PGF

Placental growth factor

PTEN

Phosphatase and tensin homolog

PHLDB2

Pleckstrin Homology Like Domain Family B Member 2

RhoA

Ras homolog gene family, member A

RNF41

Ring Finger Protein 41

RBM15

RNA binding motif protein 15

ROS

Reactive oxygen species

SAMD3

SMAD family member 3

SOX2

Sex determining region Y-box 2

SIRT1

Silencing information regulator 1

SOGA1

Suppressor of glucose, autophagy associated 1

SPRED2

Sprouty Related EVH1 Domain Containing 2

SLC2A3

Solute Carrier Family 2 Member 3

FXR2

Fragile X mental retardation syndrome-related protein 2

TCF7L2

Transcription Factor 7 Like 2

VEGF

Vascular endothelial growth factor

VIRMA

Vir-like m6A methyltransferase associated

VNPs

Vesicle-like nanoparticles

WATP,

WT1 Associated Protein

YTHDF1

YTH domain-containing family protein 1

YAP1

Yes Associated Protein 1

YTHDF2

YTH domain-containing family protein 2

YAP1

Yes Associated Protein 2

YAP

Yes1 associated transcriptional regulator

ZC3H13

Zinc finger CCCH-type containing 13

3'UTR

3'un-translated region

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