Zhou B, Perel P, Mensah GA, Ezzati M. Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nat Rev Cardiol. 2021;18:785–802. https://doi.org/10.1038/s41569-021-00559-8.

Article  PubMed  PubMed Central  Google Scholar 

Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16:223–37. https://doi.org/10.1038/s41581-019-0244-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. 2016;134:441–50. https://doi.org/10.1161/CIRCULATIONAHA.115.018912.

Article  PubMed  PubMed Central  Google Scholar 

Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140:e596–e646. https://doi.org/10.1161/CIR.0000000000000678.

Article  PubMed  PubMed Central  Google Scholar 

Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42:3227–337. https://doi.org/10.1093/eurheartj/ehab484.

Article  PubMed  Google Scholar 

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104. https://doi.org/10.1093/eurheartj/ehy339.

Article  PubMed  Google Scholar 

Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018;138:e426–e83. https://doi.org/10.1161/CIR.0000000000000597.

Article  PubMed  Google Scholar 

Boffa RJ, Constanti M, Floyd CN, Wierzbicki AS, Guideline C. Hypertension in adults: summary of updated NICE guidance. BMJ. 2019;367:l5310. https://doi.org/10.1136/bmj.l5310.

Article  PubMed  Google Scholar 

Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension global hypertension practice guidelines. Hypertension. 2020;75:1334–57. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026.

Article  CAS  PubMed  Google Scholar 

Yngve A. A historical perspective of the understanding of the link between diet and coronary heart disease. Am J Lifestyle Med. 2009;3:35S–8S. https://doi.org/10.1177/1559827609334887.

Article  PubMed  Google Scholar 

Menotti A, Puddu PE. How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: a 50-year journey. Nutr Metab Cardiovasc Dis. 2015;25:245–52. https://doi.org/10.1016/j.numecd.2014.12.001.

Article  CAS  PubMed  Google Scholar 

Russo GL, Siani A, Fogliano V, Geleijnse JM, Giacco R, Giampaoli S, et al. The Mediterranean diet from past to future: key concepts from the second “Ancel Keys” International Seminar. Nutr Metab Cardiovasc Dis. 2021;31:717–32. https://doi.org/10.1016/j.numecd.2020.12.020.

Article  PubMed  Google Scholar 

Sofi F, Macchi C, Abbate R, Gensini GF, Casini A. Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr. 2014;17:2769–82. https://doi.org/10.1017/S1368980013003169.

Article  PubMed  Google Scholar 

Schwingshackl L, Morze J, Hoffmann G. Mediterranean diet and health status: Active ingredients and pharmacological mechanisms. Br J Pharmacol. 2020;177:1241–57. https://doi.org/10.1111/bph.14778.

Article  CAS  PubMed  Google Scholar 

De Pergola G, D’Alessandro A. Influence of Mediterranean diet on blood pressure. Nutrients. 2018;10. https://doi.org/10.3390/nu10111700.

World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2000;284:3043–5.

Pitsavos C, Panagiotakos DB, Chrysohoou C, Stefanadis C. Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study. BMC Public Health. 2003;3:32. https://doi.org/10.1186/1471-2458-3-32.

Article  PubMed  PubMed Central  Google Scholar 

Nomikos T, Panagiotakos D, Georgousopoulou E, Metaxa V, Chrysohoou C, Skoumas I, et al. Hierarchical modelling of blood lipids’ profile and 10-year (2002-2012) all cause mortality and incidence of cardiovascular disease: the ATTICA study. Lipids Health Dis. 2015;14:108. https://doi.org/10.1186/s12944-015-0101-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kastorini CM, Panagiotakos DB, Chrysohoou C, Georgousopoulou E, Pitaraki E, Puddu PE, et al. Metabolic syndrome, adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: the ATTICA study. Atherosclerosis. 2016;246:87–93. https://doi.org/10.1016/j.atherosclerosis.2015.12.025.

Article  CAS  PubMed  Google Scholar 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9. https://doi.org/10.1007/bf00280883.

Article  CAS  PubMed  Google Scholar 

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.

Article  CAS  PubMed  Google Scholar 

American Diabetes Association Professional Practice C 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2022. Diabetes Care. 2022;45:S17–S38. https://doi.org/10.2337/dc22-S002.

Article  Google Scholar 

Kushner RF. Clinical assessment and management of adult obesity. Circulation. 2012;126:2870–7. https://doi.org/10.1161/CIRCULATIONAHA.111.075424.

Article  PubMed  Google Scholar 

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–5. https://doi.org/10.1161/CIRCULATIONAHA.109.192644.

Article  CAS  PubMed  Google Scholar 

Katsouyanni K, Rimm EB, Gnardellis C, Trichopoulos D, Polychronopoulos E, Trichopoulou A. Reproducibility and relative validity of an extensive semi-quantitative food frequency questionnaire using dietary records and biochemical markers among Greek schoolteachers. Int J Epidemiol. 1997;26:S118–27. https://doi.org/10.1093/ije/26.suppl_1.s118.

Article  PubMed  Google Scholar 

Panagiotakos DB, Pitsavos C, Stefanadis C. Dietary patterns: a Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis. 2006;16:559–68. https://doi.org/10.1016/j.numecd.2005.08.006.

Article  PubMed  Google Scholar 

Papathanasiou G, Georgoudis G, Papandreou M, Spyropoulos P, Georgakopoulos D, Kalfakakou V, et al. Reliability measures of the short International Physical Activity Questionnaire (IPAQ) in Greek young adults. Hellenic J Cardiol. 2009;50:283–94.

PubMed  Google Scholar 

Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35:1381–95. https://doi.org/10.1249/01.MSS.0000078924.61453.FB.

Article  PubMed  Google Scholar 

Tzima N, Pitsavos C, Panagiotakos DB, Skoumas J, Zampelas A, Chrysohoou C, et al. Mediterranean diet and insulin sensitivity, lipid profile and blood pressure levels, in overweight and obese people; the Attica study. Lipids Health Dis. 2007;6:22. https://doi.org/10.1186/1476-511X-6-22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang SZ, Lu W, Zong XF, Ruan HY, Liu Y. Obesity and hypertension. Exp Ther Med. 2016;12:2395–9. https://doi.org/10.3892/etm.2016.3667.

Article  PubMed  PubMed Central  Google Scholar 

Cowell OR, Mistry N, Deighton K, Matu J, Griffiths A, Minihane AM, et al. Effects of a Mediterranean diet on blood pressure: a systematic review and meta-analysis of randomized controlled trials and observational studies. J Hypertens. 2021;39:729–39. https://doi.org/10.1097/HJH.0000000000002667.

Article  CAS  PubMed  Google Scholar 

Nunez-Cordoba JM, Valencia-Serrano F, Toledo E, Alonso A, Martinez-Gonzalez MA. The Mediterranean diet and incidence of hypertension: the Seguimiento Universidad de Navarra (SUN) Study. Am J Epidemiol. 2009;169:339–46. https://doi.org/10.1093/aje/kwn335.

Article  PubMed  Google Scholar 

Razmpoosh E, Moslehi N, Abdollahi S, Soltani S, Mirmiran P, Azizi F. The Mediterranean, DASH, and MIND diets and the incident of hypertension over a median follow-up of 7.4 years in the Tehran Lipid and Glucose Study. BMC Public Health. 2022;22:2374. https://doi.org/10.1186/s12889-022-14843-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Damigou E, Kouvari M, Chrysohoou C, Barkas F, Kravvariti E, Pitsavos C, et al. Lifestyle trajectories are associated with incidence of cardiovascular disease: highlights from the ATTICA Epidemiological Cohort Study (2002–2022). Life. 2023;13. https://doi.org/10.3390/life13051142.

Vilarnau C, Stracker DM, Funtikov A, da Silva R, Estruch R, Bach-Faig A. Worldwide adherence to Mediterranean Diet between 1960 and 2011. Eur J Clin Nutr. 2019;72:83–91. https://doi.org/10.1038/s41430-018-0313-9.

Article  PubMed  Google Scholar