Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor

Algar WR, Hildebrandt N, Vogel SS, Medintz IL. FRET as a biomolecular research tool — understanding its potential while avoiding pitfalls. Nat Methods. 2019;16:815–29. https://doi.org/10.1038/s41592-019-0530-8.

Article  CAS  PubMed  Google Scholar 

Anastasaki C, Estep AL, Marais R, Rauen KA, Patton EE. Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors. Hum Mol Genet. 2009;18:2543–54. https://doi.org/10.1093/hmg/ddp186.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anastasaki C, Rauen KA, Patton EE. Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish. Dis Models Mech. 2012;5:546–52. https://doi.org/10.1242/dmm.008672.

Article  CAS  Google Scholar 

Andelfinger G, Marquis C, Raboisson M-J, Théoret Y, Waldmüller S, Wiegand G, et al. Hypertrophic cardiomyopathy in Noonan Syndrome treated by MEK-Inhibition. J Am Coll Cardiol. 2019;73:2237–9. https://doi.org/10.1016/j.jacc.2019.01.066.

Article  PubMed  PubMed Central  Google Scholar 

Bajar BT, Wang ES, Zhang S, Lin MZ, Chu J. A guide to fluorescent protein FRET pairs. Sens (Basel). 2016;16:1488. https://doi.org/10.3390/s16091488.

Article  CAS  Google Scholar 

Bobone S, Pannone L, Biondi B, Solman M, Flex E, Canale VC, et al. Targeting oncogenic src homology 2 domain-containing phosphatase 2 (SHP2) by inhibiting its protein-protein interactions. J Med Chem. 2021;64:15973–90. https://doi.org/10.1021/acs.jmedchem.1c01371.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J, den Hertog J. Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development. 2014a;141:1961–70. https://doi.org/10.1242/dev.106310.

Article  CAS  PubMed  Google Scholar 

Bonetti M, Rodriguez-Martinez V, Paardekooper Overman J, Overvoorde J, van Eekelen M, Jopling C, et al. Distinct and overlapping functions of ptpn11 genes in zebrafish development. PLoS ONE. 2014b;9:e94884. https://doi.org/10.1371/journal.pone.0094884.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen P-C, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, et al. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. J Clin Invest. 2010;120:4353–65. https://doi.org/10.1172/JCI43910.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Y, Tian H. Current Development Status of MEK inhibitors. Molecules. 2017;22:1551. https://doi.org/10.3390/molecules22101551.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dance M, Montagner A, Salles J-P, Yart A, Raynal P. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. Cell Signal. 2008;20:453–9. https://doi.org/10.1016/j.cellsig.2007.10.002.

Article  CAS  PubMed  Google Scholar 

Das TK, Gatto J, Mirmira R, Hourizadeh E, Kaufman D, Gelb BD, et al. Drosophila RASopathy models identify disease subtype differences and biomarkers of drug efficacy. iScience. 2021;24:102306. https://doi.org/10.1016/j.isci.2021.102306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delfini M-C, Dubrulle J, Malapert P, Chal J, Pourquié O. Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc Natl Acad Sci. 2005;102:11343–8. https://doi.org/10.1073/pnas.0502933102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dickinson ME, Bearman G, Tille S, Lansford R, Fraser SE. Multi-spectral imaging and linear unmixing add a whole new dimension to laser scanning fluorescence microscopy. Biotechniques. 2001;31:1272, 1274–6. https://doi.org/10.2144/01316bt01.

Article  Google Scholar 

Ecker RC, de Martin R, Steiner GE, Schmid JA. Application of spectral imaging microscopy in cytomics and fluorescence resonance energy transfer (FRET) analysis. Cytometry A. 2004;59:172–81. https://doi.org/10.1002/cyto.a.20053.

Article  CAS  PubMed  Google Scholar 

Ehrman LA, Nardini D, Ehrman S, Rizvi TA, Gulick J, Krenz M, et al. The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. J Neurosci. 2014;34:3767–78. https://doi.org/10.1523/JNEUROSCI.3515-13.2014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, et al. Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Neuron. 2007;54:245–62. https://doi.org/10.1016/j.neuron.2007.03.027.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gelb BD, Yohe ME, Wolf C, Andelfinger G. New prospectives on treatment opportunities in RASopathies. Am J Med Genet C Semin Med Genet. 2022;190:541–60. https://doi.org/10.1002/ajmg.c.32024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gervaise AL, Arur S. Spatial and Temporal Analysis of Active ERK in the C. Elegans Germline. J Vis Exp. 2016;54901. https://doi.org/10.3791/54901.

Gohil K, Wu S-Y, Takahashi-Yamashiro K, Shen Y, Campbell RE. Biosensor optimization using a FRET pair based on mScarlet red fluorescent protein and an mscarlet-derived green fluorescent protein. Bioengineering. 2022. https://doi.org/10.1101/2022.06.20.496847.

Article  Google Scholar 

Gotoh Y, Moriyama K, Matsuda S, Okumura E, Kishimoto T, Kawasaki H, et al. Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. EMBO J. 1991;10:2661–8. https://doi.org/10.1002/j.1460-2075.1991.tb07809.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grzmil M, Whiting D, Maule J, Anastasaki C, Amatruda JF, Kelsh RN, et al. The INT6 cancer gene and MEK signaling pathways converge during zebrafish development. PLoS ONE. 2007;2:e959. https://doi.org/10.1371/journal.pone.0000959.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Y, Di WL, Kelsell DP, Zicha D. Quantitative fluorescence resonance energy transfer (FRET) measurement with acceptor photobleaching and spectral unmixing. J Microsc. 2004;215:162–73. https://doi.org/10.1111/j.0022-2720.2004.01365.x.

Article  CAS  PubMed  Google Scholar 

Hayashi S, Ogura Y. ERK signaling dynamics in the morphogenesis and homeostasis of Drosophila. Curr Opin Genet Dev. 2020;63:9–15. https://doi.org/10.1016/j.gde.2020.01.004.

Article  CAS  PubMed  Google Scholar 

Hebron KE, Hernandez ER, Yohe ME. The RASopathies: from pathogenetics to therapeutics. Dis Model Mech. 2022;15:dmm049107. https://doi.org/10.1242/dmm.049107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hennigan RF, Chaiken MF, Foster LA, Ip W. A FRET-based approach for studying conformational changes of a cytoskeleton-related tumor suppressor molecule. Methods Mol Biol. 2009;586:143–56. https://doi.org/10.1007/978-1-60761-376-3_7.

Article  CAS  PubMed  Google Scholar 

Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, et al. K-RasV14I recapitulates Noonan syndrome in mice. Proc Natl Acad Sci U S A. 2014;111:16395–400. https://doi.org/10.1073/pnas.1418126111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holter MC, Hewitt LT, Koebele SV, Judd JM, Xing L, Bimonte-Nelson HA, et al. The Noonan syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning. PLoS Genet. 2019;15:e1008108. https://doi.org/10.1371/journal.pgen.1008108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Z, Li J, Gao Q, Wei S, Yang B. SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo. Onco Targets Ther. 2017;10:3881–91. https://doi.org/10.2147/OTT.S138833.

Article  PubMed  PubMed Central  Google Scholar 

Inoue S-I, Moriya M, Watanabe Y, Miyagawa-Tomita S, Niihori T, Oba D, et al. New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 2014;23:6553–66. https://doi.org/10.1093/hmg/ddu376.

Article  CAS  PubMed  Google Scholar 

Jares-Erijman EA, Jovin TM. FRET imaging. Nat Biotechnol. 2003;21:1387–95. https://doi.org/10.1038/nbt896.

Article  CAS  PubMed  Google Scholar 

Jindal GA, Goyal Y, Yamaya K, Futran AS, Kountouridis I, Balgobin CA, et al. In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proc Natl Acad Sci U S A. 2017;114:510–5. https://doi.org/10.1073/pnas.1615651114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jopling C, van Geemen D, den Hertog J. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 2007;3:e225. https://doi.org/10.1371/journal.pgen.0030225.

留言 (0)

沒有登入
gif