Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA. Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019;18:379–401.

Article  CAS  PubMed  Google Scholar 

Moffett JR, Namboodiri MA. Tryptophan and the immune response. Immunol Cell Biol. 2003;81:247–65.

Article  CAS  PubMed  Google Scholar 

Modoux M, Rolhion N, Mani S, Sokol H. Tryptophan metabolism as a pharmacological target. Trends Pharmacol Sci. 2021;42:60–73.

Article  CAS  PubMed  Google Scholar 

Badawy AA. Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects. Int J Tryptophan Res. 2017;10:1178646917691938.

Article  PubMed  PubMed Central  Google Scholar 

Fiore A, Murray PJ. Tryptophan and indole metabolism in immune regulation. Curr Opin Immunol. 2021;70:7–14.

Article  CAS  PubMed  Google Scholar 

Zhang J, Tao J, Ling Y, Li F, Zhu X, Xu L, et al. Switch of NAD salvage to de novo biosynthesis sustains SIRT1-RelB-dependent inflammatory tolerance. Front Immunol. 2019;10:2358.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seymour RL, Ganapathy V, Mellor AL, Munn DH. A high-affinity, tryptophan-selective amino acid transport system in human macrophages. J Leukoc Biol. 2006;80:1320–7.

Article  CAS  PubMed  Google Scholar 

Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191–3.

Article  CAS  PubMed  Google Scholar 

Jasperson LK, Bucher C, Panoskaltsis-Mortari A, Taylor PA, Mellor AL, Munn DH, et al. Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood. 2008;111:3257–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11:275–88.

Article  CAS  PubMed  Google Scholar 

Sun M, Ma N, He T, Johnston LJ, Ma X. Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR). Crit Rev Food Sci Nutr. 2020;60:1760–8.

Article  CAS  PubMed  Google Scholar 

Trinchieri G. Cancer and inflammation: an old intuition with rapidly evolving new concepts. Annu Rev Immunol. 2012;30:677–706.

Article  CAS  PubMed  Google Scholar 

Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol. 2013;34:137–43.

Article  CAS  PubMed  Google Scholar 

Boros FA, Bohar Z, Vecsei L. Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases. Mutat Res Rev Mutat Res. 2018;776:32–45.

Article  CAS  PubMed  Google Scholar 

Cao T, Dai G, Chu H, Kong C, Duan H, Tian N, et al. Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients. Hereditas. 2022;159:5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuasa HJ, Takubo M, Takahashi A, Hasegawa T, Noma H, Suzuki T. Evolution of vertebrate indoleamine 2,3-dioxygenases. J Mol Evol. 2007;65:705–14.

Article  CAS  PubMed  Google Scholar 

Pallotta MT, Rossini S, Suvieri C, Coletti A, Orabona C, Macchiarulo A, et al. Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme. FEBS J. 2022;289:6099–118.

Article  CAS  PubMed  Google Scholar 

Yan D, Lin Y-W, Tan X. Heme-containing enzymes and inhibitors for tryptophan metabolism. Metallomics. 2017;9:1230–40.

Article  CAS  PubMed  Google Scholar 

McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, et al. Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev. 2012;249:135–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volpi C, Fallarino F, Pallotta MT, Bianchi R, Vacca C, Belladonna ML, et al. High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway. Nat Commun. 2013;4:1852.

Article  PubMed  Google Scholar 

Hill M, Tanguy-Royer S, Royer P, Chauveau C, Asghar K, Tesson L, et al. IDO expands human CD4+ CD25 high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol. 2007;37:3054–62.

Article  CAS  PubMed  Google Scholar 

Tolstova T, Dotsenko E, Kozhin P, Novikova S, Zgoda V, Rusanov A, et al. The effect of TLR3 priming conditions on MSC immunosuppressive properties. Stem Cell Res Ther. 2023;14:344.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang D, Chan JFW, Yoon C, Luk TY, Shuai H, Hou Y, et al. Type-II IFN inhibits SARS-CoV-2 replication in human lung epithelial cells and ex vivo human lung tissues through indoleamine 2,3-dioxygenase-mediated pathways. J Med Virol. 2024;96:e29472.

Article  CAS  PubMed  Google Scholar 

Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, et al. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J Immunol. 2013;191:3509–13.

Article  CAS  PubMed  Google Scholar 

Loubaki L, Chabot D, Bazin R. Involvement of the TNF-α/TGF-β/IDO axis in IVIg-induced immune tolerance. Cytokine. 2015;71:181–7.

Article  CAS  PubMed  Google Scholar 

Welz B, Bikker R, Junemann J, Christmann M, Neumann K, Weber M, et al. Proteome and phosphoproteome analysis in TNF long term-exposed primary human monocytes. Int J Mol Sci. 2019;20:1241.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ibrahim OM, Basse PH, Jiang W, Guru K, Chatta G, Kalinski P. NFκB-activated COX2/PGE2/EP4 axis controls the magnitude and selectivity of BCG-induced inflammation in human bladder cancer tissues. Cancers. 2021;13:1323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng H, Huang Y, Huang G, Chen Z, Tang J, Pan L, et al. Effect of the IDO gene on pregnancy in mice with recurrent pregnancy loss. Reprod Sci. 2021;28:52–9.

Article  CAS  PubMed  Google Scholar 

Grohmann U, Volpi C, Fallarino F, Bozza S, Bianchi R, Vacca C, et al. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med. 2007;13:579–86.

Article  CAS  PubMed  Google Scholar 

Lee S-M, Kim CE, Park HY, Yoon EH, Won HJ, Ahn JM, et al. Aryl hydrocarbon receptor-targeted therapy for CD4+ / T cell-mediated idiopathic pneumonia syndrome in mice. Blood. 2022;139:3325–39.

Article  CAS  PubMed  Google Scholar 

Kong F, Saldarriaga OA, Spratt H, Osorio EY, Travi BL, Luxon BA, et al. Transcriptional profiling in experimental visceral Leishmaniasis reveals a broad splenic inflammatory environment that conditions macrophages toward a disease-promoting phenotype. PLoS Pathog. 2017;13:e1006165.

Article  PubMed  PubMed Central  Google Scholar 

Tas SW, Vervoordeldonk MJ, Hajji N, Schuitemaker JH, van der Sluijs KF, May MJ, et al. Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood. 2007;110:1540–9.

Article  CAS  PubMed  Google Scholar 

Puccetti P, Grohmann U. IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. Nat Rev Immunol. 2007;7:817–23.

Article  CAS  PubMed  Google Scholar 

Manches O, Fernandez MV, Plumas J, Chaperot L, Bhardwaj N. Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype. Proc Natl Acad Sci U S A. 2012;109:14122–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Puccetti P. On watching the watchers: IDO and type I/II IFN. Eur J Immunol. 2007;37:876–9.

Article  CAS  PubMed  Google Scholar 

Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol. 2002;3:1097–101.

Article  CAS