Yoichi Kakuta received patent royalties from Medical & Biological Laboratories Co., Ltd., research grants from AbbVie GK., Daiichi Sankyo Co. Ltd., Kyowa Kirin Co. Ltd., Takeda Pharmaceutical Co. Ltd., Medical & Biological Laboratories Co., Ltd., and Janssen Pharmaceutical K.K, lecture fees from AbbVie GK., and Janssen Pharmaceutical K.K. Toshimitsu Fujii received research grants from AbbVie, Alfresa, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, EA Pharma, Eisai, Gilead, Janssen, Kissei, Lilly, Mebix, Sanofi, and Takeda, and speaking honoraria from AbbVie, Mitsubishi Tanabe, and Takeda.　Hiroshi Nakase received honoraria from Abbvie Inc., Takeda Pharmaceutical CO., Ltd., Mitsubishi Tanabe Pharma Corporation., Janssen Pharmaceutical K.K, Gilead Sciences Inc., Pfizer Inc., EA Pharma CO., Ltd., KYORIN Pharmaceutical Co., Ltd., Mochida Pharmaceutical CO., Ltd., VIATRIS Inc, JIMRO Co., Ltd., Daiichi Sankyo Co., Ltd., grants for commissioned/joint research from Mitubishi Tanabe Pharmaceutical CO., Ltd., Abbvie Inc., EA Pharma CO., Ltd., KYORIN Pharmaceutical CO., Ltd., Mochida Pharmaceutical CO., Ltd., Nippon Kayaku Co., Ltd., Hoya group Pentax Medical; endowed chair from Miyarisan Pharmaceutical Co., Ltd., JIMRO Co., Ltd., KYORIN Pharmaceutical Co., Ltd., and Mochida Pharmaceutical Co., Ltd. Sakiko Hiraoka received lecture fee from Takeda Pharmaceutical Co. Ltd., Janssen Pharmaceutical K.K, KYORIN Pharmaceutical Co., Ltd., AbbVie GK., EA Pharma CO., Ltd., and Mitubishi Tanabe Pharmaceutical CO., Ltd. Ueno Nobuhiro received grants from Pfizer Inc. Katsuyoshi Matsuoka received lecture fees from Mitsubishi Tanabe Pharma, Takeda Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K., Abbvie Inc., EA Pharma Co., Ltd., Pfizer Inc., Mochida Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd., ZERIA Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., JIMRO Co., Ltd., Gilead Sciences, and Eli Lilly Japan K.K., and research grants from Mitsubishi Tanabe Pharma, Abbvie Inc., EA Pharma Co., Ltd., Mochida Pharmaceutical Co., Ltd., ZERIA Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd., Nippon Kayaku Co., Ltd., and JIMRO Co., Ltd. Tomohiro Fukuda received a research grant from Mitsubishi Tanabe Pharma. Tomohisa Takagi received lecture fees from Yanssen Pharmaceutical K.K., Mitsubishi Tanabe Pharma Co., Towa Pharmaceutical Co, Ltd., Mochida Pharmaceutical Co., Ltd., and research/scholarship grants from Fujifilm Medical Co., Ltd., PreMedica Inc., and Mitsubishi Tanabe Pharma. Makoto Naganuma received grants from Mitsubishi Tanabe Pharma Corporation, AbbVie GK, Kyorin Pharmaceutical Co., Ltd., and lecture fees from Tanabe Pharma Corporation, AbbVie GK, Kyorin Pharmaceutical Co., Ltd. Kissei Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., JIMRO Co., Ltd., Janssen Pharmaceutical K.K., Pfizer Japan Inc., EA Pharma Co., Ltd., Miyarisan Pharmaceutical Co., Ltd., and Mochida Pharmaceutical Co., Ltd., Corporation, AbbVie GK outside the submitted work. Hiroki Tanaka received lecture fees from JIMRO Co., Ltd., AbbVie GK, EA Pharma Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma Corporation, Janssen Pharmaceutical K.K., Nikkiso Co., Ltd., Nippon Kayaku Co., Ltd., and Takeda Pharmaceutical Co., Ltd., and received research grants from AbbVie GK, Janssen Pharmaceutical K.K., EA Pharma Co., Ltd., Takeda Pharmaceutical Co., Ltd., and AstraZeneca K.K. Takashi Ishige received lecture fee from Abbvie GK. Tadakazu Hisamatsu received research grants from EA pharma Co. Ltd., AbbVie GK, Pfizer Inc., Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co. Ltd., JIMRO Co. Ltd., Mochida Pharmaceutical Co., Ltd., Daiichi-Sankyo, Takeda Pharmaceutical Co. Ltd., Zeria Pharmaceutical Co. Ltd., and Nippon Kayaku Co. Ltd.; consulting fee from EA pharma Co. Ltd., AbbVie GK, Pfizer Inc., Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Co. Ltd., Nichi-lko Pharmaceutical Co., Ltd., Gilead Sciences, Inc., Eli Lilly and Co., and Janssen Pharmaceutical K.K.; and honoraria for lectures from EA pharma Co. Ltd., AbbVie GK, Pfizer Inc., Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co. Ltd., JIMRO Co. Ltd., Mochida Pharmaceutical Co., Ltd., Daiichi-Sankyo, Takeda Pharmaceutical Co. Ltd., Zeria Pharmaceutical Co. Ltd., Nippon Kayaku Co. Ltd., and Janssen Pharmaceutical K.K. All other authors have no conflicts of interest.