Cancer immunometabolism: advent, challenges, and perspective

Warburg O, Posener K, Negelein E. On the metabolism of carcinoma cells [J]. Biochem Z. 1924;152:309–44.

CAS  Google Scholar 

Koppenol WH, Bounds PL, Dang CV. Otto Warburg’s contributions to current concepts of cancer metabolism [J]. Nat Rev Cancer. 2011;11(5):325–37.

Article  CAS  PubMed  Google Scholar 

Dey P, Kimmelman AC, Depinho RA. Metabolic Codependencies in the Tumor Microenvironment [J]. Cancer Discov. 2021;11(5):1067–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Yan C, Ma J, et al. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma [J]. Nat Metab. 2023;5(1):61–79.

Article  CAS  PubMed  Google Scholar 

Morrissey SM, Zhang F, Ding C, et al. Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming [J]. Cell Metab. 2021;33(10):2040–58 e10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris IS, Denicola GM. The complex interplay between antioxidants and ROS in cancer [J]. Trends Cell Biol. 2020;30(6):440–51.

Article  CAS  PubMed  Google Scholar 

Boroughs LK, Deberardinis RJ. Metabolic pathways promoting cancer cell survival and growth [J]. Nat Cell Biol. 2015;17(4):351–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Reyes I, Chandel NS. Cancer metabolism: looking forward [J]. Nat Rev Cancer. 2021;21(10):669–80.

Article  CAS  PubMed  Google Scholar 

Long Y, Tao H, Karachi A, et al. Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma [J]. Cancer Res. 2020;80(3):499–509.

Article  CAS  PubMed  Google Scholar 

Nakaya M, Xiao Y, Zhou X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation [J]. Immunity. 2014;40(5):692–705.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lim SA, Wei J, Nguyen TM, et al. Lipid signalling enforces functional specialization of T(reg) cells in tumours [J]. Nature. 2021;591(7849):306–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen T, Xu ZG, Luo J, et al. NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance [J]. Cell Metab. 2023;35(10):1782–98 e8.

Article  CAS  PubMed  Google Scholar 

Reina-Campos M, Scharping NE, Goldrath AW. CD8(+) T cell metabolism in infection and cancer [J]. Nat Rev Immunol. 2021;21(11):718–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nemazee D. Mechanisms of central tolerance for B cells [J]. Nat Rev Immunol. 2017;17(5):281–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ryan DG, O’Neill LAJ. Krebs cycle reborn in macrophage immunometabolism [J]. Annu Rev Immunol. 2020;38:289–313.

Article  CAS  PubMed  Google Scholar 

Campbell C, McKenney PT, Konstantinovsky D, et al. Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells [J]. Nature. 2020;581(7809):475–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guerra L, Bonetti L, Brenner D. Metabolic modulation of immunity: a new concept in cancer immunotherapy [J]. Cell Rep. 2020;32(1):107848.

Article  CAS  PubMed  Google Scholar 

Jung J, Zeng H, Horng T. Metabolism as a guiding force for immunity [J]. Nat Cell Biol. 2019;21(1):85–93.

Article  CAS  PubMed  Google Scholar 

Chang CH, Qiu J, O’Sullivan D, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression [J]. Cell. 2015;162(6):1229–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Terry S, Engelsen AST, Buart S, et al. Hypoxia-driven intratumor heterogeneity and immune evasion [J]. Cancer Lett. 2020;492:1–10.

Article  CAS  PubMed  Google Scholar 

Huang B, Song BL, Xu C. Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities [J]. Nat Metab. 2020;2(2):132–41.

Article  PubMed  Google Scholar 

Jin J, Zhao Q, Wei Z, et al. Glycolysis-cholesterol metabolic axis in immuno-oncology microenvironment: emerging role in immune cells and immunosuppressive signaling [J]. Cell Biosci. 2023;13(1):189.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baek AE, Yu YA, He S, et al. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells [J]. Nat Commun. 2017;8(1):864.

Article  PubMed  PubMed Central  Google Scholar 

Gauci ML, Lanoy E, Champiat S, et al. Long-term survival in patients responding to Anti-PD-1/PD-L1 therapy and disease outcome upon treatment discontinuation [J]. Clin Cancer Res. 2019;25(3):946–56.

Article  PubMed  Google Scholar 

Shyer JA, Flavell RA, Bailis W. Metabolic signaling in T cells [J]. Cell Res. 2020;30(8):649–59.

Article  PubMed  PubMed Central  Google Scholar 

Artyomov MN, van den Bossche J. Immunometabolism in the single-cell era [J]. Cell Metab. 2020;32(5):710–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deretic V. Autophagy in inflammation, infection, and immunometabolism [J]. Immunity. 2021;54(3):437–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Neill LA, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists [J]. Nat Rev Immunol. 2016;16(9):553–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vrieling F, Stienstra R. Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies [J]. Trends Immunol. 2023;44(3):217–30.

Article  CAS  PubMed  Google Scholar 

Xue C, Li G, Zheng Q, et al. Tryptophan metabolism in health and disease [J]. Cell Metab. 2023;35(8):1304–26.

Article  CAS  PubMed  Google Scholar 

Zaslona Z, O’Neill LAJ. Cytokine-like roles for metabolites in immunity [J]. Mol Cell. 2020;78(5):814–23.

Article  CAS  PubMed  Google Scholar 

Haas R, Cucchi D, Smith J, et al. Intermediates of metabolism: from bystanders to signalling molecules [J]. Trends Biochem Sci. 2016;41(5):460–71.

Article  CAS  PubMed  Google Scholar 

Nagata N, Takeuchi T, Masuoka H, et al. Human gut microbiota and its metabolites impact immune responses in COVID-19 and its complications [J]. Gastroenterology. 2023;164(2):272–88.

Article  CAS  PubMed  Google Scholar 

Ryan DG, Murphy MP, Frezza C, et al. Coupling Krebs cycle metabolites to signalling in immunity and cancer [J]. Nat Metab. 2019;1:16–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, Li X, Yang F, et al. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis [J]. Nat Commun. 2021;12(1):5872.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klein Geltink RI, Edwards-Hicks J, Apostolova P, et al. Metabolic conditioning of CD8(+) effector T cells for adoptive cell therapy [J]. Nat Metab. 2020;2(8):703–16.

Article  CAS  PubMed  G

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