Synthesis, In-Silico Molecular Docking Studies, and In-Vitro Antimicrobial Evaluation of Isatin Scaffolds bearing 1, 2, 3-Triazoles using Click Chemistry

(1996) Infectious diseases kill over 17 million people a year: WHO warns of global crisis. https://www.who.int/news/item/01-01-1996-infectious-diseases-kill-over-17-million-people-a-year-who-warns-of-global-crisis

Dye C (2014) After 2015: infectious diseases in a new era of health and development. Philos Trans Royal Soc B: Biol Sci 369:20130426

Article  Google Scholar 

Marepu N, Yeturu S, Pal M (2018) 1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes. Bioorg Med Chem Lett 28:3302–3306. https://doi.org/10.1016/j.bmcl.2018.09.021

Article  CAS  PubMed  Google Scholar 

Hu YQ, Zhang S, Xu Z et al (2017) 4-Quinolone hybrids and their antibacterial activities. Eur J Med Chem 141:335–345. https://doi.org/10.1016/j.ejmech.2017.09.050

Article  CAS  PubMed  Google Scholar 

Yadav N, Mudgal D, Mishra A et al (2024) Harnessing fluorescent carbon quantum dots from natural resource for advancing sweat latent fingerprint recognition with machine learning algorithms for enhanced human identification. PLoS ONE 19:e0296270. https://doi.org/10.1371/journal.pone.0296270

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yadav N, Mudgal D, Mishra S et al (2023) Development of ionic liquid-capped carbon dots derived from Tecoma stans (L.) Juss. ex Kunth: Combatting bacterial pathogens in diabetic foot ulcer pus swabs, targeting both standard and multi-drug resistant strains. S Afr J Bot 163:412–426. https://doi.org/10.1016/j.sajb.2023.10.063

Article  CAS  Google Scholar 

Ivasiv V, Albertini C, Gonçalves AE et al (2019) Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases. Curr Top Med Chem 19:1694–1711

Article  CAS  PubMed  Google Scholar 

Singh H, Singh JV, Gupta MK et al (2017) Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies. Bioorg Med Chem Lett 27:3974–3979. https://doi.org/10.1016/j.bmcl.2017.07.069

Article  CAS  PubMed  Google Scholar 

Kumar M, Verma S, Mishra V et al (2022) Visible-Light-Accelerated Copper-Catalyzed [3+ 2] Cycloaddition of N-Tosylcyclopropylamines with Alkynes/Alkenes. J Org Chem 87:6263–6272. https://doi.org/10.1021/acs.joc.2c00491

Article  CAS  PubMed  Google Scholar 

Ngo HL, Mishra DK, Mishra V, Truong CC (2021) Recent advances in the synthesis of heterocycles and pharmaceuticals from the photo/electrochemical fixation of carbon dioxide. Chem Eng Sci 229:116142. https://doi.org/10.1016/j.ces.2020.116142

Article  CAS  Google Scholar 

Chatterjee S, Mishra V (2020) Green chemistry–Remedy to societal hygiene: a graphical review. Curr Res Gr Sustain Chem 3:100025. https://doi.org/10.1016/j.crgsc.2020.100025

Article  Google Scholar 

Yadav N, Mudgal D, Mishra V (2023) In-situ synthesis of ionic liquid-based-carbon quantum dots as fluorescence probe for hemoglobin detection. Anal Chim Acta 1272:341502. https://doi.org/10.1016/j.aca.2023.341502

Article  CAS  PubMed  Google Scholar 

Mudgal D, Singh RP, Yadav N, Mishra V (2023) Exploring the catalytic efficiency of copper-doped Magnetic carbon aerogel towards the coupling reaction of Isatin oxime with Phenylboronic acid derivatives. SynOpen 7:570–579. https://doi.org/10.1055/a-2182-7757

Article  CAS  Google Scholar 

Laurent A (1840) Recherches sur l’indigo. Ann Chim Phys 3:393–434

Google Scholar 

Erdmann OL (1840) Untersuchungen über den Indigo. J Prakt Chem 19:321–362

Article  Google Scholar 

Lan Y, Zou Y, Huang T et al (2016) Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway. Sci China Chem 59:1224–1228. https://doi.org/10.1007/s11426-016-0026-7

Article  CAS  Google Scholar 

Meleddu R, Petrikaite V, Distinto S et al (2019) Investigating the anticancer activity of Isatin/Dihydropyrazole Hybrids. ACS Med Chem Lett 10:571–576. https://doi.org/10.1021/acsmedchemlett.8b00596

Article  CAS  PubMed  Google Scholar 

Bhagat K, Bhagat J, Gupta MK et al (2019) Design, synthesis, antimicrobial evaluation, and molecular modeling studies of novel indolinedione-coumarin molecular hybrids. ACS Omega 4:8720–8730. https://doi.org/10.1021/acsomega.8b02481

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abo-Ashour MF, Eldehna WM, George RF et al (2018) Novel indole-thiazolidinone conjugates: design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents. Eur J Med Chem 160:49–60. https://doi.org/10.1016/j.ejmech.2018.10.008

Article  CAS  PubMed  Google Scholar 

Ma JY, Quan YC, Jin HG et al (2016) Practical synthesis, antidepressant, and anticonvulsant activity of 3-Phenyliminoindolin-2-one derivatives. Chem Biol Drug Des 87:342–351. https://doi.org/10.1111/cbdd.12668

Article  CAS  PubMed  Google Scholar 

Meleddu R, Distinto S, Corona A et al (2015) (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase. Eur J Med Chem 93:452–460. https://doi.org/10.1016/j.ejmech.2015.02.032

Article  CAS  PubMed  Google Scholar 

Kumar S, Bains T, Won Kim AS et al (2018) Highly potent 1H–1,2,3-triazole-tethered isatin-metronidazole conjugates against anaerobic foodborne, waterborne, and sexually-transmitted protozoal parasites. Front Cell Infect Microbiol 8:2–10. https://doi.org/10.3389/fcimb.2018.00380

Article  CAS  Google Scholar 

Wang G, Chen M, Qiu J et al (2018) Synthesis, in vitro α-glucosidase inhibitory activity and docking studies of novel chromone-isatin derivatives. Bioorg Med Chem Lett 28:113–116. https://doi.org/10.1016/j.bmcl.2017.11.047

Article  CAS  PubMed  Google Scholar 

Xu Z, Zhang S, Song X et al (2017) Design, synthesis and in vitro anti-mycobacterial evaluation of gatifloxacin-1H-1,2,3-triazole-isatin hybrids. Bioorg Med Chem Lett 27:3643–3646. https://doi.org/10.1016/j.bmcl.2017.07.023

Article  CAS  PubMed  Google Scholar 

Xu Z, Song XF, Hu YQ et al (2017) Azide-alkyne cycloaddition towards 1H–1,2,3-triazole-tethered gatifloxacin and isatin conjugates: Design, synthesis and in vitro anti-mycobacterial evaluation. Eur J Med Chem 138:66–71. https://doi.org/10.1016/j.ejmech.2017.05.057

Article  CAS  PubMed  Google Scholar 

Song F, Li Z, Bian Y et al (2020) Indole/isatin-containing hybrids as potential antibacterial agents. Arch Pharm (Weinheim) 353:2000143

Article  CAS  Google Scholar 

Kolb HC, Sharpless KB (2003) The growing impact of click chemistry on drug discovery. Drug Discov Today 8:1128–1137

Article  CAS  PubMed  Google Scholar 

Liang L, Astruc D (2011) The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) “click” reaction and its applications. An overview Coord Chem Rev 255:2933–2945. https://doi.org/10.1016/j.ccr.2011.06.028

Article  CAS  Google Scholar 

Mishra V, Kumar R (2019) Cyclic polymer of N-vinylpyrrolidone via ATRP protocol: kinetic study and concentration effect of polymer on click chemistry in solution. Polym Sci Ser B 61:753–761. https://doi.org/10.1134/S1560090419060095

Article  Google Scholar 

Mishra V, Kumar R (2011) RAFT polymerization of N-vinyl pyrrolidone using prop-2-ynyl morpholine-4-carbodithioate as a new chain transfer agent. J Appl Polym Sci 124:4475–4485. https://doi.org/10.1002/app.35480

Article  CAS  Google Scholar 

Mishra V, Jung S-H, Jeong HM, Lee H (2014) Thermoresponsive ureido-derivatized polymers: the effect of quaternization on UCST properties. Polym Chem 5:2411–2416. https://doi.org/10.1039/C3PY01648J

Article  CAS  Google Scholar 

Yadav N, Gaikwad RP, Mishra V, Gawande MB (2022) Synthesis and photocatalytic applications of functionalized carbon quantum dots. Bull Chem Soc Jpn 95:1638–1679. https://doi.org/10.1246/bcsj.20220250

Article  CAS  Google Scholar 

Kumar A, Yadav AK, Mishra V, Kumar D (2023) Recent Advancements in triazole-based click chemistry in cancer drug discovery and development. SynOpen 7:186–208. https://doi.org/10.1055/s-0042-1751452

Article  CAS  Google Scholar 

Nuzzi A, Massi A, Dondoni A (2007) Model studies toward the synthesis of thymidine oligonucleotides with triazole internucleosidic linkages via iterative Cu (I)-promoted azide–alkyne ligation chemistry. QSAR Comb Sci 26:1191–1199

Article  CAS  Google Scholar 

Yadav N, Mudgal D, Anand R et al (2022) Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications. Int J Biol Macromol 220:537–572. https://doi.org/10.1016/j.ijbiomac.2022.08.098

Article  CAS  PubMed  Google Scholar 

Miljanić OŠ, Dichtel WR, Aprahamian I et al (2007) Rotaxanes and catenanes by click chemistry. QSAR Comb Sci 26:1165–1174. https://doi.org/10.1002/qsar.200740070

Article  CAS  Google Scholar 

Kraljević TG, Harej A, Sedić M et al (2016) Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids. Eur J Med Chem 124:794–808. https://doi.org/10.1016/j.ejmech.2016.08.062

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif