The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance

Amuguni H, Tzipori S (2012) Bacillus subtilis A temperature resistant and needle free delivery system of immunogens © 2012 Landes Bioscience. Do not distribute © 2012 Landes Bioscience. Do Not Distribute Hum Vaccin Immunother 8:979–986

Article  CAS  PubMed Central  Google Scholar 

Baldauf KJ, Royal JM, Hamorsky KT, Matoba N (2015) Cholera toxin B: One subunit with many pharmaceutical applications. Toxins (basel) 7:974–996. https://doi.org/10.3390/toxins7030974

Article  CAS  PubMed  Google Scholar 

Batsuli G, Meeks SL, Herzog RW, Lacroix-Desmazes S (2016) Innovating immune tolerance induction for haemophilia. Haemophilia 22:31–35. https://doi.org/10.1111/hae.12989

Article  PubMed  Google Scholar 

Berntorp E (2023) Immune tolerance induction in development. Blood 141:1901–1902. https://doi.org/10.1182/blood.2022019465

Article  CAS  PubMed  Google Scholar 

Bin SJ, Holmgren J, Czerkinsky C (1994) Cholera toxin B subunit: An efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc Natl Acad Sci USA 91:10795–10799. https://doi.org/10.1073/pnas.91.23.10795

Article  Google Scholar 

Chavin SI (1984) Factor VIII: Structure and function in blood clotting. Am J Hematol 16:297–306. https://doi.org/10.1002/ajh.2830160312

Article  CAS  PubMed  Google Scholar 

Chunfeng G, Xiaozhou L, Gang W et al (2013) Expression of cholera toxin B-lumbrokinase fusion protein in Pichia pastoris - The use of transmucosal carriers in the delivery of therapeutic proteins to protect rats against thrombosis. Appl Biochem Biotechnol 169:636–650. https://doi.org/10.1007/s12010-012-0004-2

Article  CAS  PubMed  Google Scholar 

Dimichele DM (2012) Immune tolerance in haemophilia: The long journey to the fork in the road. Br J Haematol 159:123–134. https://doi.org/10.1111/bjh.12028

Article  CAS  PubMed  Google Scholar 

Franchini M, Mannucci PM (2012) Past, present and future of hemophilia: a narrative review. Orphanet J Rare Dis 7:1–8. https://doi.org/10.1186/1750-1172-7-24

Article  Google Scholar 

Hardet R, Mingozzi F (2017) Oral tolerance: another reason to eat your veggies! Mol Ther 25:311–313. https://doi.org/10.1016/j.ymthe.2017.01.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herzog RW, Nichols TC, Su J et al (2017) Oral tolerance induction in hemophilia B dogs fed with transplastomic lettuce. Mol Ther 25:512–522. https://doi.org/10.1016/j.ymthe.2016.11.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu B, Li C, Lu H et al (2011) Immune responses to the oral administration of recombinant Bacillus subtilis expressing multi-epitopes of foot-and-mouth disease virus and a cholera toxin B subunit. J Virol Methods 171:272–279. https://doi.org/10.1016/j.jviromet.2010.11.023

Article  CAS  PubMed  Google Scholar 

Jiang H, Bian Q, Zeng W et al (2019) Oral delivery of Bacillus subtilis spores expressing grass carp reovirus VP4 protein produces protection against grass carp reovirus infection. Fish Shellfish Immunol 84:768–780. https://doi.org/10.1016/j.fsi.2018.10.008

Article  CAS  PubMed  Google Scholar 

Kim YC, Zhang AH, Su Y et al (2015) Engineered antigen-specific human regulatory T cells: Immunosuppression of FVIII-specific T- and B-cell responses. Blood 125:1107–1115. https://doi.org/10.1182/blood-2014-04-566786

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kosloski MP, Miclea RD, Balu-Iyer SV (2009) Role of glycosylation in conformational stability, activity, macromolecular interaction and immunogenicity of recombinant human factor VIII. AAPS J 11:424–431. https://doi.org/10.1208/s12248-009-9119-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krishnamoorthy S, Liu T, Drager D et al (2016) Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice. Cell Immunol 301:30–39. https://doi.org/10.1016/J.CELLIMM.2015.12.008

Article  CAS  PubMed  Google Scholar 

Kwon KC, Sherman A, Chang WJ et al (2018) Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in haemophilia A mice. Plant Biotechnol J 16:1148–1160. https://doi.org/10.1111/pbi.12859

Article  CAS  PubMed  Google Scholar 

Lenting PJ, van Mourik JA, Mertens K (1998) The life cycle of coagulation factor VIII in view of its structure and function. Blood 92:3983–3996. https://doi.org/10.1182/blood.v92.11.3983

Article  CAS  PubMed  Google Scholar 

Li W, Feng J, Li J et al (2019) Surface display of antigen protein VP8* of porcine rotavirus on Bacillus subtilis spores using COtB as a fusion partner. Molecules. https://doi.org/10.3390/molecules24203793

Article  PubMed  PubMed Central  Google Scholar 

Mancuso ME, Cannavò A (2015) Immune tolerance induction in hemophilia. Clin Investig (lond) 5:321–335. https://doi.org/10.4155/cli.14.122

Article  CAS  Google Scholar 

Mimoun A, Bou-Jaoudeh M, Delignat S et al (2023) Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy. J Thromb Haemost. https://doi.org/10.1016/j.jtha.2023.05.021

Article  PubMed  Google Scholar 

Moghimi B, Sack BK, Nayak S et al (2011) Induction of tolerance to factor VIII by transient co-administration with rapamycin. J Thromb Haemost 9:1524–1533. https://doi.org/10.1111/j.1538-7836.2011.04351.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mou C, Zhu L, Yang J et al (2016) Immune responses induced by recombinant Bacillus Subtilis expressing the hemagglutinin protein of H5N1 in chickens. Sci Rep 6:1–11. https://doi.org/10.1038/srep38403

Article  CAS  Google Scholar 

Neef J, van Dijl JM, Buist G (2021) Recombinant protein secretion by Bacillus subtilis and lactococcus lactis: Pathways, applications, and innovation potential. Essays Biochem 65:187–195. https://doi.org/10.1042/EBC20200171

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pinheiro-Rosa N, Torres L, de Oliveira M, A, et al (2021) Oral tolerance as antigen-specific immunotherapy. Immunother Adv 1:1–21. https://doi.org/10.1093/immadv/ltab017

Article  Google Scholar 

Ruhlman T, Ahangari R, Devine A et al (2007) Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts - Oral administration protects against development of insulitis in non-obese diabetic mice. Plant Biotechnol J 5:495–510. https://doi.org/10.1111/j.1467-7652.2007.00259.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sack BK, Herzog RW, Terhorst C, Markusic DM (2014) Development of gene transfer for induction of antigen-specific tolerance. Mol Ther - Methods Clin Dev 1:14013. https://doi.org/10.1038/mtm.2014.13

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sánchez J, Holmgren J (2008) Cholera toxin structure, gene regulation and pathophysiological and immunological aspects. Cell Mol Life Sci 65:1347–1360. https://doi.org/10.1007/s00018-008-7496-5

Article  CAS  PubMed  Google Scholar 

Sarkar D, Biswas M, Liao G et al (2014) Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia. Mol Ther - Methods Clin Dev 1:14030. https://doi.org/10.1038/mtm.2014.30

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schep SJ, Schutgens REG, Fischer K, Boes ML (2018) Review of immune tolerance induction in hemophilia A. Blood Rev 32:326–338. https://doi.org/10.1016/j.blre.2018.02.003

Article  CAS  PubMed  Google Scholar 

Scott DW, Pratt KP, Miao CH (2013) Progress toward inducing immunologic tolerance to factor VIII. Blood 121:4449–4456. https://doi.org/10.1182/blood-2013-01-478669

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shafaati M, Ghorbani M, Mahmoodi M et al (2022) Expression and characterization of hemagglutinin–neuraminidase protein from Newcastle disease virus in Bacillus subtilis WB800. J Genet Eng Biotechnol. https://doi.org/10.1186/s43141-022-00357-w

Article  PubMed  PubMed Central  Google Scholar 

Shen BW, Spiegel PC, Chang CH et al (2008) The tertiary structure and domain organization of coagulation factor VIII. Blood 111:1240–1247. https://doi.org/10.1182/blood-2007-08-109918

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherman A, Su J, Lin S et al (2014) Suppression of inhibitor formation against FVIII in a murine model of hemophilia a by oral delivery of antigens bioencapsulated in plant cells. Blood 124:1659–1668. https://doi.org/10.1182/blood-2013-10-528737

Article  CAS 

留言 (0)

沒有登入
gif