World Health Organization (WHO). 2023. Global Tuberculosis Report 2023. https://iris.who.int/bitstream/handle/10665/373828/9789240083851-eng.pdf?sequence=1

Prevention KcfDCa. Korean Guidelines for Tuberculosis. In: Prevention KcfDCa, ed. 4th ed, 2020.

Cho KS. Tuberculosis control in the Republic of Korea. Epidemiol Health. 2018;40:e2018036.

Article  PubMed  PubMed Central  Google Scholar 

McGrath M, van Gey NC, van Helden PD, Warren RM, Warner DF. Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis. J Antimicrob Chemother. 2014;69:292–302.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Yew WW. Mechanisms of drug resistance in Mycobacterium tuberculosis. Int J Tuberc Lung Dis. 2009;13:1320–30.

CAS  PubMed  Google Scholar 

Chakravorty S, Simmons AM, Rowneki M, Parmar H, Cao Y, Ryan J, Banada PP, Deshpande S, Shenai S, Gall A, Glass J, Krieswirth B, Schumacher SG, Nabeta P, Tukvadze N, Rodrigues C, Skrahina A, Tagliani E, Cirillo DM, Davidow A, Denkinger CM, Persing D, Kwiatkowski R, Jones M, Alland D. 2017. The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing. mBio 8.

Dorman SE, Schumacher SG, Alland D, Nabeta P, Armstrong DT, King B, Hall SL, Chakravorty S, Cirillo DM, Tukvadze N, Bablishvili N, Stevens W, Scott L, Rodrigues C, Kazi MI, Joloba M, Nakiyingi L, Nicol MP, Ghebrekristos Y, Anyango I, Murithi W, Dietze R, Lyrio Peres R, Skrahina A, Auchynka V, Chopra KK, Hanif M, Liu X, Yuan X, Boehme CC, Ellner JJ, Denkinger CM. Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis. 2018;18:76–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azuara D, Ginesta MM, Gausachs M, Rodriguez-Moranta F, Fabregat J, Busquets J, Pelaez N, Boadas J, Galter S, Moreno V, Costa J, de Oca J, Capellá G. Nanofluidic digital PCR for KRAS mutation detection and quantification in gastrointestinal cancer. Clin Chem. 2012;58:1332–41.

Article  CAS  PubMed  Google Scholar 

Dingle TC, Sedlak RH, Cook L, Jerome KR. Tolerance of droplet-digital PCR vs real-time quantitative PCR to inhibitory substances. Clin Chem. 2013;59:1670–2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hindson BJ, Ness KD, Masquelier DA, Belgrader P, Heredia NJ, Makarewicz AJ, Bright IJ, Lucero MY, Hiddessen AL, Legler TC, Kitano TK, Hodel MR, Petersen JF, Wyatt PW, Steenblock ER, Shah PH, Bousse LJ, Troup CB, Mellen JC, Wittmann DK, Erndt NG, Cauley TH, Koehler RT, So AP, Dube S, Rose KA, Montesclaros L, Wang S, Stumbo DP, Hodges SP, Romine S, Milanovich FP, White HE, Regan JF, Karlin-Neumann GA, Hindson CM, Saxonov S, Colston BW. High-throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem. 2011;83:8604–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

SM C, S S, Y K, W S, SG H, SH J, MS K, KA L. A novel approach for tuberculosis diagnosis using exosomal DNA and droplet digital PCR. Clin Microbiol Infect. 2020;26:e9421–5.

Article  Google Scholar 

Burd EM. Validation of laboratory-developed molecular assays for infectious diseases. Clin Microbiol Rev. 2010;23:550–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang JY, Hur J, Kim S, Jeon S, Lee J, Kim YJ, Kim SC, Park YJ, Kim YK, Moon HS. Clinical implications of discrepant results between genotypic MTBDRplus and phenotypic Löwenstein-Jensen method for isoniazid or rifampicin drug susceptibility tests in tuberculosis patients. J Thorac Disease. 2019;11:400.

Article  Google Scholar 

Ahmad S, Mokaddas E, Al-Mutairi N, Eldeen HS, Mohammadi S. Discordance across phenotypic and molecular methods for drug susceptibility testing of drug-resistant Mycobacterium tuberculosis isolates in a low TB incidence country. PLoS ONE. 2016;11:e0153563.

Article  PubMed  PubMed Central  Google Scholar 

Hofmann-Thiel S, Hoffmann H, Hillemann D, Rigouts L, Van Deun A, Kranzer K. How should discordance between molecular and growth-based assays for rifampicin resistance be investigated? Int J Tuberc Lung Dis. 2017;21:721–6.

Article  CAS  PubMed  Google Scholar 

Susskind MM, Botstein D. Molecular genetics of bacteriophage P22. Microbiol Rev. 1978;42:385–413.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Soolingen D, Qian L, de Haas PE, Douglas JT, Traore H, Portaels F, Qing HZ, Enkhsaikan D, Nymadawa P, van Embden JD. Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia. J Clin Microbiol. 1995;33:3234–8.

Article  PubMed  PubMed Central  Google Scholar 

Nguyen HV, de Haas P, Nguyen HB, Nguyen NV, Cobelens FGJ, Mirtskhulava V, Finlay A, Van Nguyen H, Huyen PTT, Tiemersma EW. Discordant results of Xpert MTB/Rif assay and BACTEC MGIT 960 liquid culture to detect Mycobacterium tuberculosis in community screening in Vietnam. BMC Infect Dis. 2022;22:506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Howard ST, Oughton MT, Haddad A, Johnson WM. Absence of the genetic marker IS6110 from a strain of Mycobacterium tuberculosis isolated in Ontario. Can J Infect Dis. 1998;9(1):48–53.

CAS  PubMed  PubMed Central  Google Scholar 

Park YK, Kang HY, Lim JG, Ha JS, Cho JO, Lee KC, Choi HS, Choi YH, Sheen SS, Bai GH. Analysis of DNA fingerprints of Mycobacterium tuberculosis isolates from patients registered at Health Center in Gyeonggi Province in 2004. Tuberc Respir Dis. 2006;60(3):290–6.

Article  Google Scholar 

Cao Y, Parmar H, Gaur RL, Lieu D, Raghunath S, Via N, Battaglia S, Cirillo DM, Denkinger C, Georghiou S, Kwiatkowski R, Persing D, Alland D, Chakravorty S. 2021. Xpert MTB/XDR: a 10-Color Reflex Assay suitable for point-of-care settings to detect Isoniazid, Fluoroquinolone, and second-line-injectable-drug resistance directly from Mycobacterium tuberculosis-positive Sputum. J Clin Microbiol 59.

McQuaid CF, Vassall A, Cohen T, Fiekert K, White RG. The impact of COVID-19 on TB: a review of the data. Int J Tuberc Lung Dis. 2021;25:436–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Min J, Kim HW, Kim JS, Tuberculosis. Republic of Korea, 2021. Tuberc Respir Dis (Seoul). 2023;86(1):67–9.

Article  PubMed  Google Scholar 

Jnawali HN, Hwang SC, Park YK, Kim H, Lee YS, Chung GT, Choe KH, Ryoo S. Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea. Diagn Microbiol Infect Dis. 2013;76:187–96.

Article  CAS  PubMed  Google Scholar 

Ko DH, Lee EJ, Lee SK, Kim HS, Shin SY, Hyun J, Kim JS, Song W, Kim HS. Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation. Ann Clin Microbiol Antimicrob. 2019;18:2.

Article  PubMed  PubMed Central  Google Scholar 

Farhat MR, Jacobson KR, Franke MF, Kaur D, Sloutsky A, Mitnick CD, Murray M. Gyrase mutations are Associated with variable levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis. J Clin Microbiol. 2016;54:727–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park J, Shin SY, Kim K, Park K, Shin S, Ihm C. Determining Genotypic Drug Resistance by Ion Semiconductor sequencing with the Ion AmpliSeq™ TB Panel in Multidrug-Resistant Mycobacterium tuberculosis isolates. Ann Lab Med. 2018;38:316–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farhat MR, Sultana R, Iartchouk O, Bozeman S, Galagan J, Sisk P, Stolte C, Nebenzahl-Guimaraes H, Jacobson K, Sloutsky A, Kaur D, Posey J, Kreiswirth BN, Kurepina N, Rigouts L, Streicher EM, Victor TC, Warren RM, van Soolingen D, Murray M. Genetic determinants of Drug Resistance in Mycobacterium tuberculosis and their diagnostic value. Am J Respir Crit Care Med. 2016;194:621–30.

Article  CAS  PubMed  PubMed Central  Google Scholar