aKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education

bDepartment of Physiology, Shanxi Medical University

cDepartment of Pathophysiology, Shanxi Medical University

dDepartment of Cardiovascular Surgery, Shanxi Bethune Hospital

eCenter for Hypertension Care, Shanxi Medical University First Hospital

fDepartment of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan,

gState Key Laboratory of Medical Molecular Biology, Department of Cell Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing

hKey Laboratory of Medical Electrophysiology at Southwest Medical University, Ministry of Education, and the Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China

Correspondence to Ji-Min Cao, Shanxi Medical University, Taiyuan 030001, China. Tel: +86 351 4135246; e-mail: [email protected]

Abbreviations: BAPN, β-aminopropionitrile monofumarate; CRISPR/Cas9, clustered regularly interspaced short palindromic repeats; MMP2, matrix metalloproteinase 2; MMP9, matrix metalloproteinase 9; NE, norepinephrine; NGF, nerve growth factor; Sema3A, semaphorin 3A; SNS, sympathetic nervous system; TAAD, thoracic aortic aneurysm dissection; TH, tyrosine hydroxylase; VSMCs, vascular smooth muscle cells

Received 30 August, 2023

Revised 21 November, 2023

Accepted 6 December, 2023

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