Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study

Alagaratnam J, Winston A (2022) Molecular neuroimaging of inflammation in HIV. In Clin Exp Immunol 210(1). https://doi.org/10.1093/cei/uxab013

Anthony IC, Ramage SN, Carnie FW, Simmonds P, Bell JE (2005) Influence of HAART on HIV-related CNS disease and neuroinflammation. J Neuropathol Exp Neurol. https://doi.org/10.1093/jnen/64.6.529

Article  PubMed  Google Scholar 

Banati RB, Egensperger R, Maassen A, Hager G, Kreutzberg GW, Graeber MB (2004) Mitochondria in activated microglia in vitro. J Neurocytol. https://doi.org/10.1007/s11068-004-0515-7

Article  PubMed  Google Scholar 

Boerwinkle AH, Strain JF, Burdo T, Doyle J, Christensen J, Su Y, Wisch JK, Cooley SA, Vaida F, Smith MD, Jafri H, Paul RH, Benzinger TLS, Ances BM (2020) Comparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals. J Acquired Immune Defic Syndr 85(2). https://doi.org/10.1097/QAI.0000000000002435

Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB (2001) In-vivo measurement of activated microglia in dementia. Lancet. https://doi.org/10.1016/S0140-6736(01)05625-2

Article  PubMed  Google Scholar 

Coughlin JM, Wang Y, Ma S, Yue C, Kim PK, Adams AV, Roosa HV, Gage KL, Stathis M, Rais R, Rojas C, McGlothan JL, Watkins CC, Sacktor N, Guilarte TR, Zhou Y, Sawa A, Slusher BS, Caffo B, Pomper MG (2014) Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV. J NeuroVirol. https://doi.org/10.1007/s13365-014-0239-5

Article  PubMed  PubMed Central  Google Scholar 

Drugan RC (1996) Peripheral benzodiazepine receptors: Molecular pharmacology to possible physiological significance in stress-induced hypertension. In Clinical Neuropharmacology. https://doi.org/10.1097/00002826-199619060-00002

Article  Google Scholar 

Edén A, Marcotte TD, Heaton RK, Nilsson S, Zetterberg H, Fuchs D, Franklin D, Price RW, Grant I, Letendre SL, Gisslén M (2016) Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment. PLoS ONE 11(6). https://doi.org/10.1371/journal.pone.0157160

Garvey LJ, Pavese N, Politis M, Ramlackhansingh A, Brooks DJ, Taylor-Robinson SD, Winston A (2014) Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART. AIDS 28(1):67–72. https://doi.org/10.1097/01.aids.0000432467.54003.f7

Article  CAS  PubMed  Google Scholar 

Gavish M, Bachman I, Shoukrun R, Katz Y, Veenman L, Weisinger G, Weizman A (1999) Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev

Gunn RN, Lammertsma AA, Grasby PM (2000) Quantitative analysis of [carbonyl-11C]WAY-100635 PET studies. Nucl Med Biol. https://doi.org/10.1016/S0969-8051(00)00115-3

Article  PubMed  Google Scholar 

Hammoud DA, Endres CJ, Chander AR, Guilarte TR, Wong DF, Sacktor NC, McArthur JC, Pomper MG (2005) Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS. J NeuroVirol 11(4). https://doi.org/10.1080/13550280500187351

Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S (2019) Very Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma. J Infect Dis. https://doi.org/10.1093/infdis/jiz030

Article  PubMed  PubMed Central  Google Scholar 

Hogg RS, Heath KV, Yip B, Craib KJ, O’Shaughnessy MV, Schechter MT, Montaner JS (1998) Improved survival among HIV-infected individuals following initiation of antiretroviral therapy. JAMA, J Am Med Assoc 279(6):450–454. https://doi.org/10.1001/jama.279.6.450

Article  CAS  Google Scholar 

Jučaite A, Cselényi Z, Arvidsson A, Åhlberg G, Julin P, Varnäs K, Stenkrona P, Andersson J, Halldin C, Farde L (2012) Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects. EJNMMI Res. https://doi.org/10.1186/2191-219X-2-15

Article  PubMed  PubMed Central  Google Scholar 

Lavisse S, Guillermier M, Hérard AS, Petit F, Delahaye M, Van Camp NV, Haim LB, Lebon V, Remy P, Dollé F, Delzescaux T, Bonvento G, Hantraye P, Escartin C (2012) Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. J Neurosci. https://doi.org/10.1523/JNEUROSCI.1487-12.2012

Article  PubMed  PubMed Central  Google Scholar 

Liu GJ, Middleton RJ, Hatty CR, Kam WWY, Chan R, Pham T, Harrison-Brown M, Dodson E, Veale K, Banati RB (2014) The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathol. https://doi.org/10.1111/bpa.12196

Article  PubMed  PubMed Central  Google Scholar 

May MT, Gompels M, Delpech V, Porter K, Orkin C, Kegg S, Hay P, Johnson M, Palfreeman A, Gilson R, Chadwick D, Martin F, Hill T, Walsh J, Post F, Fisher M, Ainsworth J, Jose S, Leen C, Sabin C (2014) Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. AIDS (London, England) 28(8):1193–1202. https://doi.org/10.1097/QAD.0000000000000243

Article  PubMed  Google Scholar 

Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C (2002) The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurolog Sci 202(1–2). https://doi.org/10.1016/S0022-510X(02)00207-1

Nightingale S, Dreyer AJ, Saylor D, Gisslén M, Winston A, Joska JA (2021) Moving on From HAND: Why We Need New Criteria for Cognitive Impairment in Persons Living With Human Immunodeficiency Virus and a Proposed Way Forward. Clin Infect Dis 73(6). https://doi.org/10.1093/cid/ciab366

Oliveira MF, Chaillon A, Nakazawa M, Vargas M, Letendre SL, Strain MC, Ellis RJ, Morris S, Little SJ, Smith DM, Gianella S (2017) Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations. PLoS Pathog. https://doi.org/10.1371/journal.ppat.1006112

Article  PubMed  PubMed Central  Google Scholar 

Owen DR, Guo Q, Kalk NJ, Colasanti A, Kalogiannopoulou D, Dimber R, Lewis YL, Libri V, Barletta J, Ramada-Magalhaes J, Kamalakaran A, Nutt DJ, Passchier J, Matthews PM, Gunn RN, Rabiner EA (2014) Determination of [11C]PBR28 binding potential in vivo: A first human TSPO blocking study. J Cereb Blood Flow Metab. https://doi.org/10.1038/jcbfm.2014.46

Article  PubMed  PubMed Central  Google Scholar 

Owen DR, Narayan N, Wells L, Healy L, Smyth E, Rabiner EA, Galloway D, Williams JB, Lehr J, Mandhair H, Peferoen LAN, Taylor PC, Amor S, Antel JP, Matthews PM, Moore CS (2017) Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans. J Cereb Blood Flow Metabol 37(8). https://doi.org/10.1177/0271678X17710182

Pace M, Frater J (2014) A cure for HIV: Is it in sight? Exp Rev Anti-Infect Ther 12(7):783–791. https://doi.org/10.1586/14787210.2014.910112

Article  CAS  Google Scholar 

Paul S, Gallagher E, Liow JS, Mabins S, Henry K, Zoghbi SS, Gunn RN, Kreisl WC, Richards EM, Zanotti-Fregonara P, Morse CL, Hong J, Kowalski A, Pike VW, Innis RB, Fujita M (2019) Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects. J Cereb Blood Flow Metab. https://doi.org/10.1177/0271678X18771250

Article  PubMed  Google Scholar 

Rissanen E, Tuisku J, Vahlberg T, Sucksdorff M, Paavilainen T, Parkkola R, Rokka J, Gerhard A, Hinz R, Talbot PS, Rinne JO, Airas L (2018) Microglial activation, white matter tract damage, and disability in MS. Neurology - Neuroimmunology Neuroinflammation. https://doi.org/10.1212/nxi.0000000000000443

Article  Google Scholar 

Robertson KR, Smurzynski M, Parsons TD, Wu K, Bosch RJ, Wu J, Mcarthur JC, Collier AC, Evans SR, Ellis RJ (2007) The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS (london, England) 21(14):1915–1921. https://doi.org/10.1097/QAD.0b013e32828e4e27

Article  PubMed  Google Scholar 

Rubin LH, Sacktor N, Creighton J, Du Y, Endres CJ, Pomper MG, Coughlin JM (2018) Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy. AIDS 32(12). https://doi.org/10.1097/QAD.0000000000001858

Schouten J, Wit FW, Stolte IG, Kootstra NA, Van Der Valk M, Geerlings SE, Prins M, Reiss P (2014) Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between hiv-infected and uninfected individuals: The age H IV cohort study. Clin Infect Dis 59(12):1787–1797. https://doi.org/10.1093/cid/ciu701

Article  CAS  PubMed  Google Scholar 

Schuitemaker A, van der Doef TF, Boellaard R, van der Flier WM, Yaqub M, Windhorst AD, Barkhof F, Jonker C, Kloet RW, Lammertsma AA, Scheltens P, van Berckel BNM (2012) Microglial activation in healthy aging. Neurobiol Aging. https://doi.org/10.1016/j.neurobiolaging.2010.09.016

Article  PubMed  Google Scholar 

Simioni S, Cavassini M, Annoni J-M, Rimbault Abraham A, Bourquin I, Schiffer V, Calmy A, Chave J-P, Giacobini E, Hirschel B, Du Pasquier RA. (2010) Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS (london, England) 24(9):1243–1250. https://doi.org/10.1097/QAD.0b013e3283354a7b

Article  PubMed  Google Scholar 

Stephenson DT, Schober DA, Smalstig EB, Mincy RE, Gehlert DR, Clemens JA (1995) Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci 15(7 Pt 2):5263–5274. http://www.ncbi.nlm.nih.gov/pubmed/7623150

Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Cervenka S (2019) Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study. Eur J Nucl Med Mol Imaging. https://doi.org/10.1007/s00259-019-04403-7

Ulfhammer G, Eden A, Mellgren S, Fuchs D, Zetterberg H, Hagberg L, Nilsson S, Yilmaz A, Gisslen M (2018) Persistent central nervous system immune activation following more than 10 years of effective HIV antiretroviral treatment. AIDS. https://doi.org/10.1097/QAD.0000000000001950

Article  PubMed  Google Scholar 

Vera JH, Guo Q, Cole JH, Boasso A, Greathead L, Kelleher P, Rabiner EA, Kalk N, Bishop C, Gunn RN, Matthews PM, Winston A (2016) Neuroinflammation in treated HIV-positive individuals: A TSPO PET study. Neurology 86(15):1425–1432. https://doi.org/10.1212/WNL.0000000000002485

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiley CA, Lopresti BJ, Becker JT, Boada F, Lopez OL, Mellors J, Meltzer CC, Wisniewski SR, Mathis CA (2006) Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment. J NeuroVirol 12(4). https://doi.org/10.1080/13550280600873868

Yilmaz A, Price RW, Spudich S, Fuchs D, Hagberg L, Gisslén M (2008) Persistent intrathecal immune activation in HIV-1-infected individuals on antiretroviral therapy. J Acquir Immune Defic Syndr. https://doi.org/10.1097/QAI.0b013e31815ace97

Article  PubMed  PubMed Central  Google Scholar 

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