Jia L, Kim S, Yu H. Tracking spindle checkpoint signals from kinetochores to APC/C. Trends Biochem Sci. 2013;38(6):302–11.

Article  CAS  PubMed  Google Scholar 

Musacchio A. The molecular biology of spindle assembly checkpoint signaling dynamics. Curr Biol. 2015;25(20):R1002–18.

Article  CAS  PubMed  Google Scholar 

Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007;8(5):379–93.

Article  CAS  PubMed  Google Scholar 

Li M, Fang X, Wei Z, York JP, Zhang P. Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol. 2009;185(6):983–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volonte D, Sedorovitz M, Galbiati F. Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non-small cell lung cancer cells. J Biol Chem. 2022;298(10):102405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suijkerbuijk SJ, van Osch MH, Bos FL, Hanks S, Rahman N, Kops GJ. Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Cancer Res. 2010;70(12):4891–900.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol. 2009;19(22):1937–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lara-Gonzalez P, Pines J, Desai A. Spindle assembly checkpoint activation and silencing at kinetochores. Semin Cell Dev Biol. 2021;117:86–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nijenhuis W, von Castelmur E, Littler D, De Marco V, Tromer E, Vleugel M, et al. A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B. J Cell Biol. 2013;201(2):217–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vigneron S, Prieto S, Bernis C, Labbe JC, Castro A, Lorca T. Kinetochore localization of spindle checkpoint proteins: who controls whom? Mol Biol Cell. 2004;15(10):4584–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caldas GV, DeLuca KF, DeLuca JG. KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity. J Cell Biol. 2013;203(6):957–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

London N, Biggins S. Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint. Genes Dev. 2014;28(2):140–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamagishi Y, Yang CH, Tanno Y, Watanabe Y. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components. Nat Cell Biol. 2012;14(7):746–52.

Article  CAS  PubMed  Google Scholar 

Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, et al. Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling. Elife. 2013;2:e01030.

Article  PubMed  PubMed Central  Google Scholar 

Sharp-Baker H, Chen RH. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J Cell Biol. 2001;153(6):1239–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, et al. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol. 2005;15(3):214–25.

Article  PubMed  Google Scholar 

Kulukian A, Han JS, Cleveland DW. Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell. 2009;16(1):105–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burton JL, Solomon MJ. Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev. 2007;21(6):655–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chao WC, Kulkarni K, Zhang Z, Kong EH, Barford D. Structure of the mitotic checkpoint complex. Nature. 2012;484(7393):208–13.

Article  CAS  PubMed  Google Scholar 

Sudakin V, Chan GK, Yen TJ. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol. 2001;154(5):925–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faesen AC, Thanasoula M, Maffini S, Breit C, Muller F, van Gerwen S, et al. Basis of catalytic assembly of the mitotic checkpoint complex. Nature. 2017;542(7642):498–502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Irniger S, Piatti S, Michaelis C, Nasmyth K. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell. 1995;81(2):269–78.

Article  CAS  PubMed  Google Scholar 

King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 1995;81(2):279–88.

Article  CAS  PubMed  Google Scholar 

Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, et al. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell. 1995;6(2):185–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tugendreich S, Tomkiel J, Earnshaw W, Hieter P. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell. 1995;81(2):261–8.

Article  CAS  PubMed  Google Scholar 

Izawa D, Pines J. The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C. Nature. 2015;517(7536):631–4.

Article  CAS  PubMed  Google Scholar 

May KM, Paldi F, Hardwick KG. Fission yeast Apc15 stabilizes MCC-Cdc20-APC/C complexes, ensuring efficient Cdc20 Ubiquitination and checkpoint arrest. Curr Biol. 2017;27(8):1221–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sewart K, Hauf S. Different functionality of Cdc20 binding sites within the mitotic checkpoint complex. Curr Biol. 2017;27(8):1213–20.

Article  CAS  PubMed  Google Scholar 

Prinz S, Hwang ES, Visintin R, Amon A. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis. Curr Biol. 1998;8(13):750–60.

Article  CAS  PubMed  Google Scholar 

King EM, van der Sar SJ, Hardwick KG. Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. Plos One. 2007;2(4):e342.

Article  PubMed  PubMed Central  Google Scholar 

Pan J, Chen RH. Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev. 2004;18(12):1439–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nilsson J, Yekezare M, Minshull J, Pines J. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol. 2008;10(12):1411–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barford D. Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions. Curr Opin Struct Biol. 2020;61:86–97.

Article  CAS  PubMed  Google Scholar 

Gross F, Bonaiuti P, Hauf S, Ciliberto A. Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex. Plos Comput Biol. 2018;14(9):e1006449.

Article  PubMed  PubMed Central  Google Scholar 

Kataria M, Yamano H. Interplay between Phosphatases and the Anaphase-promoting complex/Cyclosome in Mitosis. Cells. 2019;8(8):814.