Protein N-terminal acetylation is entering the degradation end game

Aksnes, H., Ree, R. & Arnesen, T. Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases. Mol. Cell 73, 1097–1114 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bachmair, A., Finley, D. & Varshavsky, A. In vivo half-life of a protein is a function of its amino-terminal residue. Science 234, 179–186 (1986).

Article  CAS  PubMed  Google Scholar 

Varshavsky, A. N-degron and C-degron pathways of protein degradation. Proc. Natl Acad. Sci. USA 116, 358–366 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown, J. L. & Roberts, W. K. Evidence that approximately eighty per cent of the soluble proteins from Ehrlich ascites cells are Nalpha-acetylated. J. Biol. Chem. 251, 1009–1014 (1976).

Article  CAS  PubMed  Google Scholar 

Arnesen, T. et al. Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc. Natl Acad. Sci. USA 106, 8157–8162 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mayer, A., Siegel, N. R., Schwartz, A. L. & Ciechanover, A. Degradation of proteins with acetylated amino termini by the ubiquitin system. Science 244, 1480–1483 (1989).

Article  CAS  PubMed  Google Scholar 

Hwang, C. S., Shemorry, A. & Varshavsky, A. N-terminal acetylation of cellular proteins creates specific degradation signals. Science 327, 973–977 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shemorry, A., Hwang, C. S. & Varshavsky, A. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol. Cell 50, 540–551 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, H. K. et al. The N-terminal methionine of cellular proteins as a degradation signal. Cell 156, 158–169 (2014).

Article  CAS  PubMed  Google Scholar 

Park, S. E. et al. Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway. Science 347, 1249–1252 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kats, I. et al. Mapping degradation signals and pathways in a eukaryotic N-terminome. Mol. Cell 70, 488–501 (2018).

Article  CAS  PubMed  Google Scholar 

Linster, E. et al. Cotranslational N-degron masking by acetylation promotes proteome stability in plants. Nat. Commun. 13, 810 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mueller, F. et al. Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization. Sci. Adv. 7, eabc8590 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Varland, S. et al. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nat. Commun. 14, 6774 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

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