Abisambra JF, Jinwal UK, Blair LJ, O’Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, et al. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci. 2013;33(22):9498–507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct. 2008;33(1):75–89.

Article  CAS  PubMed  Google Scholar 

Ajoolabady A, Liu S, Klionsky DJ, Lip GYH, Tuomilehto J, Kavalakatt S, Pereira DM, Samali A, Ren J. ER stress in obesity pathogenesis and management. Trends Pharmacol Sci. 2022;43(2):97–109.

Article  CAS  PubMed  Google Scholar 

Andruska N, Zheng X, Yang X, Helferich WG, Shapiro DJ. Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor alpha-positive breast cancer. Oncogene. 2015;34(29):3760–9.

Article  CAS  PubMed  Google Scholar 

Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, Bouchecareilh M, Magnin N, Favereaux A, Maitre M, Gaiser T, et al. Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma. Proc Natl Acad Sci U S A. 2010;107(35):15553–8.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Bae D, Jones RE, Piscopo KM, Tyagi M, Shepherd JD, Hollien J. Regulation of Blos1 by IRE1 prevents the accumulation of huntingtin protein aggregates. Mol Biol Cell. 2022;33(13):ar125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barua D, Gupta A, Gupta S. Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: opportunities and challenges. Cancer Lett. 2020;486:29–37.

Article  CAS  PubMed  Google Scholar 

Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene. 2010;29(27):3881–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burris HA, Bakewell S, Bendell JC, Infante J, Jones SF, Spigel DR, Weiss GJ, Ramanathan RK, Ogden A, Von Hoff D. Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort. ESMO Open. 2016;1(6):e000154.

Article  PubMed  Google Scholar 

Cao W, Zhang T, Feng R, Xia T, Huang H, Liu C, Sun C. Hoxa5 alleviates obesity-induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue. J Cell Mol Med. 2019;23(10):7029–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerezo M, Lehraiki A, Millet A, Rouaud F, Plaisant M, Jaune E, Botton T, Ronco C, Abbe P, Amdouni H, et al. Compounds triggering ER stress exert Anti-melanoma effects and overcome BRAF inhibitor resistance. Cancer Cell. 2016;29(6):805–19.

Article  CAS  PubMed  Google Scholar 

Chen X, Cubillos-Ruiz JR. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer. 2021;21(2):71–88.

Article  CAS  PubMed  Google Scholar 

Chen Y, Wu Z, Zhao S, Xiang R. Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity. Sci Rep. 2016;6:27486.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Cisse M, Duplan E, Checler F. The transcription factor XBP1 in memory and cognition: implications in Alzheimer disease. Mol Med. 2017;22:905–17.

Article  PubMed  PubMed Central  Google Scholar 

Credle JJ, Forcelli PA, Delannoy M, Oaks AW, Permaul E, Berry DL, Duka V, Wills J, Sidhu A. Alpha-synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson’s disease. Neurobiol Dis. 2015;76:112–25.

Article  CAS  PubMed  Google Scholar 

Dejeans N, Manie S, Hetz C, Bard F, Hupp T, Agostinis P, Samali A, Chevet E. Addicted to secrete - novel concepts and targets in cancer therapy. Trends Mol Med. 2014;20(5):242–50.

Article  CAS  PubMed  Google Scholar 

Dikic I. Proteasomal and autophagic degradation systems. Annu Rev Biochem. 2017;86:193–224.

Article  CAS  PubMed  Google Scholar 

Dsouza VL, Shivakumar AB, Kulal N, Gangadharan G, Kumar D, Kabekkodu SP. Phytochemical based Modulation of Endoplasmic Reticulum Stress in Alzheimer’s Disease. Curr Top Med Chem. 2022;22(22):1880–96.

Article  CAS  PubMed  Google Scholar 

Du Y, Liu X, Zhu X, Liu Y, Wang X, Wu X. Activating transcription factor 6 reduces Abeta1-42 and restores memory in Alzheimer’s disease model mice. Int J Neurosci. 2020;130(10):1015–23.

Article  CAS  PubMed  Google Scholar 

Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles AO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, et al. IRE1 signaling exacerbates Alzheimer’s disease pathogenesis. Acta Neuropathol. 2017;134(3):489–506.

Article  CAS  PubMed  Google Scholar 

Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles AO, Diaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, et al. The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis. Mol Ther. 2023;31(7):2240–56.

Article  CAS  PubMed  Google Scholar 

El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, et al. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021;17(12):4363–85.

Article  PubMed  PubMed Central  Google Scholar 

Espina M, Di Franco N, Branas-Navarro M, Navarro IR, Brito V, Lopez-Molina L, Costas-Insua C, Guzman M, Gines S. The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington’s disease R6/1 mice. Neurobiol Dis. 2023;184:106225.

Article  CAS  PubMed  Google Scholar 

Ezquerro S, Becerril S, Tuero C, Mendez-Gimenez L, Mocha F, Moncada R, Valenti V, Cienfuegos JA, Catalan V, Gomez-Ambrosi J, et al. Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats. Int J Obes (Lond). 2020;44(2):475–87.

Article  CAS  PubMed  Google Scholar 

Fan P, Jordan VC. How PERK kinase conveys stress signals to nuclear factor-kappab to mediate estrogen-induced apoptosis in breast cancer cells? Cell Death Dis. 2018;9(8):842.

Article  PubMed  PubMed Central  Google Scholar 

Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, et al. Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress. Cancer Discov. 2014;4(6):702–15.

Article  CAS  PubMed  Google Scholar 

Fernandez-Fernandez MR, Ferrer I, Lucas JJ. Impaired ATF6alpha processing, decreased Rheb and neuronal cell cycle re-entry in Huntington’s disease. Neurobiol Dis. 2011;41(1):23–32.

Article  CAS  PubMed  Google Scholar 

Finkbeiner S. Huntington’s Disease. Cold Spring Harb Perspect Biol 2011, 3(6).

Fu Y, Li J, Lee AS. GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer Res. 2007;67(8):3734–40.

Article  CAS  PubMed  Google Scholar 

Ganz J, Shacham T, Kramer M, Shenkman M, Eiger H, Weinberg N, Iancovici O, Roy S, Simhaev L, Da’adoosh B, et al. A novel specific PERK activator reduces toxicity and extends survival in Huntington’s disease models. Sci Rep. 2020;10(1):6875.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013;5(3):a013169.

Article  PubMed  PubMed Central  Google Scholar 

Geng J, Guo Y, Xie M, Li Z, Wang P, Zhu D, Li J, Cui X. Characteristics of endoplasmic reticulum stress in colorectal cancer for predicting prognosis and developing treatment options. Cancer Med. 2023;12(10):12000–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghemrawi R, Khair M. Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases. Int J Mol Sci 2020, 21(17).

Goossens JF, Bailly C. Ursodeoxycholic acid and cancer: from chemoprevention to chemotherapy. Pharmacol Ther. 2019;203:107396.

Article  CAS  PubMed  Google Scholar 

Gorbatyuk MS, Shabashvili A, Chen W, Meyers C, Sullivan LF, Salganik M, Lin JH, Lewin AS, Muzyczka N, Gorbatyuk OS. Glucose regulated protein 78 diminishes alpha-synuclein neurotoxicity in a rat model of Parkinson disease. Mol Ther. 2012;20(7):1327–37.

Article  CAS