Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant

Naot D., Musson D.S., Cornish J. 2019. The activity of peptides of the calcitonin family in bone. Physiol. Rev. 99 (1), 781‒805.

Article  CAS  PubMed  Google Scholar 

Sekiguchi T. 2018. The calcitonin/calcitonin gene-related peptide family in invertebrate deuterostomes. Front. Endocrinol. 9, 695.

Article  Google Scholar 

Hoogwerf B.J., Doshi K.B., Diab D. 2008. Pramlintide, the synthetic analogue of amylin, physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. Vasc. Health Risk. Manage. 4 (2), 355‒362.

Article  CAS  Google Scholar 

Nikitenko L., Fox S., Kehoe S., Rees M., Bicknell R. 2006. Adrenomedullin and tumour angiogenesis. Br. J. Cancer. 94 (1), 1‒7.

Article  CAS  PubMed  Google Scholar 

Caron K.M., Smithies O. 2001. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc. Natl. Acad. Sci. U. S. A. 98 (2), 615‒619.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shindo T., Kurihara Y., Nishimatsu H., Moriyama N., Kakoki M., Wang Y., Imai Y., Ebihara A., Kuwaki T., Ju K.-H. 2001. Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation. 104 (16), 1964‒1971.

Article  CAS  PubMed  Google Scholar 

Cornish J., Callon K., Bava U., Kamona S., Cooper G., Reid I. 2001. Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. Bone. 29 (2), 162‒168.

Article  CAS  PubMed  Google Scholar 

Dacquin R., Davey R.A., Laplace C., Levasseur R., Morris H.A., Goldring S.R., Gebre-Medhin S., Galson D.L., Zajac J.D., Karsenty G. 2004. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J. Cell Biol. 164 (4), 509‒514.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naot D., Cornish J. 2008. The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism. Bone. 43 (5), 813‒818.

Article  CAS  PubMed  Google Scholar 

Kapurniotu A. 2004. Contribution of conformationally constrained calcitonin (Ct) analogs to the understanding of the structural and conformational requirements of calcitonin bioactivity and to the design of potent agonists. Curr. Med. Chem. 11 (21), 2845‒2865.

Article  CAS  PubMed  Google Scholar 

Johansson E., Hansen J.L., Hansen A.M.K., Shaw A.C., Becker P., Schäffer L., Reedtz-Runge S. 2016. Type II turn of receptor-bound salmon calcitonin revealed by X-ray crystallography. J. Biol. Chem. 291 (26), 13689‒13698.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pearse A.G.E. 1966. The cytochemistry of the thyroid C cells and their relationship to calcitonin. Proc. R Soc. London, Ser. B. 164 (996), 478‒487.

Article  CAS  Google Scholar 

Friedman J., Raisz L.G. 1965. Thyrocalcitonin: Inhibitor of bone resorption in tissue culture. Science. 150 (3702), 1465‒1467.

Article  CAS  PubMed  Google Scholar 

Granholm S., Henning P., Lerner U.H. 2011. Comparisons between the effects of calcitonin receptor-stimulating peptide and intermedin and other peptides in the calcitonin family on bone resorption and osteoclastogenesis. J. Cell. Biochem. 112 (11), 3300‒3312.

Article  CAS  PubMed  Google Scholar 

Felsenfeld A.J., Levine B.S. 2015. Calcitonin, the forgotten hormone: Does it deserve to be forgotten? Clin. Kidney J. 8 (2), 180‒187.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stroop S.D., Nakamuta H., Kuestner R.E., Moore E.E., Epand R.M. 1996. Determinants for calcitonin analog interaction with the calcitonin receptor N-terminus and transmembrane-loop regions. Endocrinology. 137 (11), 4752‒4756.

Article  CAS  PubMed  Google Scholar 

Wimalawansa S.J. 1997. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: A peptide superfamily. Crit. Rev. Neurobiol. 11 (2-3), 167‒239.

Article  CAS  PubMed  Google Scholar 

Stevenson C.L. 2009. Advances in peptide pharmaceuticals. Curr. Pharm. Biotechnol. 10 (1), 122‒137.

Article  CAS  PubMed  Google Scholar 

Guggi D., Bernkop-Schnürch A. 2003. In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases. Int. J. Pharm. 252 (1-2), 187‒196.

Article  CAS  PubMed  Google Scholar 

Lang S.R., Staudenmann W., James P., Manz H.-J., Kessler R., Galli B., Moser H.-P., Rummelt A., Merkle H.P. 1996. Proteolysis of human calcitonin in excised bovine nasal mucosa: Elucidation of the metabolic pathway by liquid secondary lonization mass spectrometry (LSIMS) and matrix assisted laser desorption lonization mass spectrometry (MALDI). Pharm. Res. 13 (11), 1679‒1685.

Article  CAS  PubMed  Google Scholar 

Kozono T., Hirata M., Endo K., Satoh K., Takanashi H., Miyauchi T., Fukushima N., Kumagai E., Abe S., Matsuda E. 1992. A chimeric analog of human and salmon calcitonin eliminates antigenicity and reduces gastrointestinal disturbances. Endocrinology. 131 (6), 2885‒2890.

Article  CAS  PubMed  Google Scholar 

Zarei M., Nezafat N., Rahbar M.R., Negahdaripour M., Sabetian S., Morowvat M.H., Ghasemi Y. 2019. Decreasing the immunogenicity of arginine deiminase enzyme via structure-based computational analysis. J. Biomol. Struct. Dyn. 37 (2), 523‒536.

Article  CAS  PubMed  Google Scholar 

Wimalawansa S.J. 1993. Long-and short-term side effects and safety of calcitonin in man: A prospective study. Calcif. Tissue Int. 52 (2), 90‒93.

Article  CAS  PubMed  Google Scholar 

Negahdaripour M., Eslami M., Nezafat N., Hajighahramani N., Ghoshoon M.B., Shoolian E., Dehshahri A., Erfani N., Morowvat M.H., Ghasemi Y. 2017. A novel HPV prophylactic peptide vaccine, designed by immunoinformatics and structural vaccinology approaches. Infect. Genet. Evol. 54, 402‒416.

Article  CAS  PubMed  Google Scholar 

Zarei M., Rahbar M.R., Negahdaripour M., Morowvat M.H., Nezafat N., Ghasemi Y. 2020. Cell penetrating peptide: Sequence-based computational prediction for intercellular delivery of arginine deiminase. Curr. Proteomics. 17 (2), 117‒131.

Article  CAS  Google Scholar 

Rahmatabadi S.S., Nezafat N., Negahdaripour M., Hajighahramani N., Morowvat M.H., Ghasemi Y. 2016. Studying the features of 57 confirmed CRISPR loci in 29 strains of Escherichia coli. J. Basic Microbiol. 56 (6), 645‒653.

Article  CAS  PubMed  Google Scholar 

Karimi Z., Nezafat N., Negahdaripour M., Berenjian A., Hemmati S., Ghasemi Y. 2015. The effect of rare codons following the ATG start codon on expression of human granulocyte-colony stimulating factor in Escherichia coli. Protein Expr. Purif. 114, 108‒114.

Article  CAS  PubMed  Google Scholar 

Rahbar M.R., Zarei M., Jahangiri A., Khalili S., Nezafat N., Negahdaripour M., Fattahian Y., Ghasemi Y. 2020. Pierce into the native structure of Ata, a trimeric autotransporter of Acinetobacter baumannii ATCC 17978. Int. J. Peptide Res. Ther. 26, 1269‒1282.

Article  CAS  Google Scholar 

UniProt Consortium 2019. UniProt: A worldwide hub of protein knowledge. Nucleic Acids Res. 47 (D1), D506‒D515.

Article  Google Scholar 

Gasteiger E., Hoogland C., Gattiker A., Wilkins M.R., Appel R.D., Bairoch A. 2005. Protein identification and analysis tools on the ExPASy server. In The Proteomics Protocols Handbook. Walker J.M., Ed. Humana Press, pp. 571‒607.

Google Scholar 

Doytchinova I.A., Flower D.R. 2007. VaxiJen: A server for prediction of protective antigens, tumour antigens and subunit vaccines. BMC Bioinf. 8, 4.

Article  Google Scholar 

Kolaskar A.S., Tongaonkar P.C. 1990. A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett. 276 (1–2), 172‒174.

Article  CAS  PubMed  Google Scholar 

Kringelum J.V., Lundegaard C., Lund O., Nielsen M. 2012. Reliable B cell epitope predictions: Impacts of method development and improved benchmarking. PLoS Comput. Biol. 8 (12), e1002829.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ponomarenko J., Bui H.-H., Li W., Fusseder N., Bourne P.E., Sette A., Peters B. 2008. ElliPro: A new structure-based tool for the prediction of antibody epitopes. BMC Bioinf. 9 (1), 514.

Article  Google Scholar 

Jespersen M.C., Peters B., Nielsen M., Marcatili P. 2017. BepiPred-2.0: Improving sequence-based B-cell epitope prediction using conformational epitopes. Nucleic Acids Res. 45 (W1), W24‒W29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ligeti B., Vera R., Juhász J., Pongor S. 2017. CX, DPX, and PCW: Web servers for the visualization of interior and protruding regions of protein structures in 3D and 1D. In Prediction of Protein Secondary Structure. Springer, pp. 301‒309.

Google Scholar 

Pandurangan A.P., Ochoa-Montaño B., Ascher D.B., Blundell T.L. 2017. SDM: A server for predicting effects of mutations on protein stability. Nucleic Acids Res. 45 (W1), W229‒W235.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif