Soejima Y, Shimada M, Suehiro T, Kishikawa K, Yoshizumi T, Hashimoto K, et al. Use of steatotic graft in living-donor liver transplantation. Transplantation. 2003;76:344–48. https://doi.org/10.1097/01.TP.0000071205.52835.A4

Article  PubMed  Google Scholar 

Bhangui P, Sah J, Choudhary N, Gautam D, Gupta V, Srinivasan T, et al. Safe use of right lobe live donor livers with up to 20% macrovesicular steatosis without compromising donor safety and recipient outcome. Transplantation. 2020;104:308–16. https://doi.org/10.1097/TP.0000000000002847

Article  CAS  PubMed  Google Scholar 

Yoon YI, Song GW, Lee SG, Park GC, Hwang S, Kim KH, et al. Safe use of right lobe living donor livers with moderate steatosis in adult-to-adult living donor liver transplantation: a retrospective study. Transpl Int. 2021;34:872–81. https://doi.org/10.1111/tri.13859

Article  PubMed  Google Scholar 

Miller CM, Durand F, Heimbach JK, Kim-Schluger L, Lee SG, Lerut J, et al. The international liver transplant society guideline on living liver donation. Transplantation. 2016;100:1238–43. https://doi.org/10.1097/TP.0000000000001247

Article  PubMed  Google Scholar 

Chu MJ, Dare AJ, Phillips AR, Bartlett AS. Donor hepatic steatosis and outcome after liver transplantation: a systematic review. J Gastrointest Surg. 2015;19:1713–24. https://doi.org/10.1007/s11605-015-2832-1

Article  PubMed  Google Scholar 

Rose JT, Vargas P, Seay T, Pesch AJ, Williams T, Sites A, et al. Lose weight to donate: development of a program to optimize potential donors with hepatic steatosis or obesity for living liver donation. Transplant Direct. 2021;7:e702. https://doi.org/10.1097/TXD.0000000000001161

Article  PubMed  PubMed Central  Google Scholar 

Hwang S, Lee SG, Jang SJ, Cho SH, Kim KH, Ahn CS, et al. The effect of donor weight reduction on hepatic steatosis for living donor liver transplantation. Liver Transpl. 2004;10:721–25. https://doi.org/10.1002/lt.20172

Article  PubMed  Google Scholar 

Oshita A, Tashiro H, Amano H, Kobayashi T, Onoe T, Ide K, et al. Safety and feasibility of diet-treated donors with steatotic livers at the initial consultation for living-donor liver transplantation. Transplantation. 2012;93:1024–30. https://doi.org/10.1097/TP.0b013e31824c9e25

Article  CAS  PubMed  Google Scholar 

Doyle A, Adeyi O, Khalili K, Fischer S, Dib M, Goldaracena N, et al. Treatment with Optifast reduces hepatic steatosis and increases candidacy rates for living donor liver transplantation. Liver Transpl. 2016;22:1295–300. https://doi.org/10.1002/lt.24495

Article  PubMed  Google Scholar 

Chung JH, Ryu JH, Yang KH, Choi BH, Park Y, Lee TB, et al. Efficacy and safety of weight reduction of the donor in hepatic steatosis for living donor liver transplantation. Ann Transplant. 2020;25:e923211

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trakroo S, Bhardwaj N, Garg R, Modaresi EJ. Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: a systematic review and meta-analysis. World J Gastroenterol. 2021;27:3682–92. https://doi.org/10.3748/wjg.v27.i24.3682

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pamecha V, Patil NS, Parthasarathy K, Sinha PK, Mohapatra N, Rastogi A, et al. Expanding donor pool for live donor liver transplantation: utilization of donors with non-alcoholic steatohepatitis after optimization. Langenbecks Arch Surg. 2022;407:1575–84. https://doi.org/10.1007/s00423-022-02444-5

Article  PubMed  Google Scholar 

Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol. 2007;102:2708–15

Article  PubMed  Google Scholar 

Park HJ, Kim KW, Kwon HJ, Lee S, Kim DW, Moon HH, et al. CT-based visual grading system for assessment of hepatic steatosis: diagnostic performance and interobserver agreement. Hepatol Int. 2022;16:1075–84. https://doi.org/10.1007/s12072-022-10373-0

Article  PubMed  Google Scholar 

Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA, NASH Clinical Research Network (CRN). Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology. 2011;53:810–20

Article  CAS  PubMed  Google Scholar 

Fujii Y, Kawamura N, Zaitsu M, Watanabe M, Goto R, Kamiyama T, et al. Outcome of living-donor liver transplantation using grafts from donors treated for fatty liver. Ann Transplant. 2020;25:e920677

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian H, Hakkarainen A, Lundbom N, Yki-Järvinen H. Effects of dietary interventions on liver volume in humans. Obesity (Silver Spring). 2014;22:989–95. https://doi.org/10.1002/oby.20623

Article  CAS  PubMed  Google Scholar 

Lewis MC, Phillips ML, Slavotinek JP, Kow L, Thompson CH, Toouli J. Change in liver size and fat content after treatment with Optifast very low calorie diet. Obes Surg. 2006;16:697–701. https://doi.org/10.1381/096089206777346682

Article  PubMed  Google Scholar 

Chu KK, Wong KH, Chok KS. Expanding indications for liver transplant: tumor and patient factors. Gut Liver. 2021;15:19–30. https://doi.org/10.5009/gnl19265

Article  CAS  PubMed  Google Scholar 

Broering DC, Sterneck M, Rogiers X. Living donor liver transplantation. J Hepatol. 2003;38(Suppl 1):S119–S35. https://doi.org/10.1016/s0168-8278(03)00009-6

Article  PubMed  Google Scholar 

Müllhaupt B, Dimitroulis D, Gerlach JT, Clavien PA. Hot topics in liver transplantation: organ allocation—extended criteria donor—living donor liver transplantation. J Hepatol. 2008;48(Suppl 1):S58–S67. https://doi.org/10.1016/j.jhep.2008.01.013

Article  PubMed  Google Scholar 

Goldaracena N, Sapisochin G, Spetzler V, Echeverri J, Kaths M, Cattral MS, et al. Live donor liver transplantation with older (≥50 years) versus younger (<50 years) donors: does age matter? Ann Surg. 2016;263:979–85. https://doi.org/10.1097/SLA.0000000000001337

Article  PubMed  Google Scholar 

Egawa H, Teramukai S, Haga H, Tanabe M, Fukushima M, Shimazu M. Present status of ABO-incompatible living donor liver transplantation in Japan. Hepatology. 2008;47:143–52. https://doi.org/10.1002/hep.21928

Article  PubMed  Google Scholar 

Song GW, Lee SG, Moon DB, Ahn CS, Hwang S, Kim KH, et al. Dual-graft adult living donor liver transplantation: an innovative surgical procedure for live liver donor pool expansion. Ann Surg. 2017;266:10–18. https://doi.org/10.1097/SLA.0000000000001776

Article  PubMed  Google Scholar 

McCormack L, Dutkowski P, El-Badry AM, Clavien PA. Liver transplantation using fatty livers: always feasible? J Hepatol. 2011;54:1055–62. https://doi.org/10.1016/j.jhep.2010.11.004

Article  PubMed  Google Scholar 

Doyle MB, Vachharajani N, Wellen JR, Anderson CD, Lowell JA, Shenoy S, et al. Short- and long-term outcomes after steatotic liver transplantation. Arch Surg. 2010;145:653–60. https://doi.org/10.1001/archsurg.2010.119

Article  PubMed  Google Scholar 

Nagai S, Fujimoto Y, Kamei H, Nakamura T, Kiuchi T. Mild hepatic macrovesicular steatosis may be a risk factor for hyperbilirubinaemia in living liver donors following right hepatectomy. Br J Surg. 2009;96:437–44. https://doi.org/10.1002/bjs.6479

Article  CAS  PubMed  Google Scholar 

El-Badry AM, Breitenstein S, Jochum W, Washington K, Paradis V, Rubbia-Brandt L, et al. Assessment of hepatic steatosis by expert pathologists: the end of a gold standard. Ann Surg. 2009;250:691–97. https://doi.org/10.1097/SLA.0b013e3181bcd6dd

Article  PubMed  Google Scholar 

Machado MV, Cortez-Pinto H. Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal. J Hepatol. 2013;58:1007–19. https://doi.org/10.1016/j.jhep.2012.11.021

Article  PubMed  Google Scholar 

Reeder SB, Hu HH, Sirlin CB. Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration. J Magn Reson Imaging. 2012;36:1011–14. https://doi.org/10.1002/jmri.23741

Article  PubMed  PubMed Central  Google Scholar 

Danis N, Weeks SR, Kim A, Baghdadi A, Ghadimi M, Kamel IR, et al. Noninvasive risk stratification for nonalcoholic fatty liver disease among living liver donor candidates: a proposed algorithm. Liver Transpl. 2022;28:670–77. https://doi.org/10.1002/lt.26365

Article  PubMed  Google Scholar