Agarwal S, Tiwari SK, Seth B, Yadav A, Singh A, Mudawal A, Chauhan LKS, Gupta SK, Choubey V, Tripathi A (2015) Activation of autophagic flux against xenoestrogen bisphenol-A-induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of rapamycin (mTOR) pathways. J Biol Chem 290:21163–21184

Article  PubMed  PubMed Central  Google Scholar 

Alcalay RN, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L, Ross BM, Verbitsky M, Kisselev S, Louis ED, Comella C (2010) Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch Neurol 67:1116–1122

Article  PubMed  PubMed Central  Google Scholar 

Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R (2009) LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 18:4022–4034

Article  PubMed  PubMed Central  Google Scholar 

Annese T, Tamma R, De Giorgis M, Ribatti D (2020) microRNAs biogenesis, functions and role in tumor angiogenesis. Front Oncol 10:581007

Article  PubMed  PubMed Central  Google Scholar 

Ansari A, Maffioletti E, Milanesi E, Marizzoni M, Frisoni GB, Blin O, Richardson JC, Bordet R, Forloni G, Gennarelli M (2019) miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer’s disease. Neurobiol Aging 82:102–109

Article  PubMed  Google Scholar 

Ba R-Q, Liu J, Fan X-J, Jin G-L, Huang B-G, Liu M-W, Yang J-S (2020) Effects of miR-199a on autophagy by targeting glycogen synthase kinase 3β to activate PTEN/AKT/mTOR signaling in an MPP+ in vitro model of Parkinson’s disease. Neurol Res 42:308–318

Article  PubMed  Google Scholar 

Bai X, Dong Q, Zhao L, Yao Y, Wang B (2021) microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson’s disease. Neurosci Lett 760:136094

Article  PubMed  Google Scholar 

Barbato C, Giacovazzo G, Albiero F, Scardigli R, Scopa C, Ciotti M, Strimpakos G, Coccurello R, Ruberti F (2020) Cognitive decline and modulation of Alzheimer’s disease-related genes after inhibition of MicroRNA-101 in Mouse hippocampal neurons. Mol Neurobiol 57:3183–3194

Article  PubMed  Google Scholar 

Bonifati V (2006) Parkinson’s disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson’s disease genetics. Euro J Human Genet: EJHG 14:1061

Article  Google Scholar 

Checkoway H, Lundin JI, Kelada SN (2011) Neurodegenerative diseases. IARC Sci Publ 163:407–419

Google Scholar 

Chen J, Jiang C, Du J, Xie C-L (2020) MiR-142-5p protects against 6-OHDA-induced SH-SY5Y cell injury by downregulating BECN1 and autophagy. Dose Response 18:1559325820907016

Article  PubMed  PubMed Central  Google Scholar 

Chen M-L, Hong C-G, Yue T, Li H-M, Duan R, Hu W-B, Cao J, Wang Z-X, Chen C-Y, Hu X-K (2021) Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer’s disease by enhancing autophagy. Theranostics 11:2395

Article  PubMed  PubMed Central  Google Scholar 

Cheng J, Liao Y, Dong Y, Hu H, Yang N, Kong X, Li S, Li X, Guo J, Qin L (2020) Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice. Autophagy 16:2193–2205

Article  PubMed  PubMed Central  Google Scholar 

Chiu C-C, Yeh T-H, Chen R-S, Chen H-C, Huang Y-Z, Weng Y-H, Cheng Y-C, Liu Y-C, Cheng A-J, Lu Y-C (2019) Upregulated expression of microRNA-204-5p leads to the death of dopaminergic cells by targeting DYRK1A-mediated apoptotic signaling cascade. Front Cell Neurosci 13:399

Article  PubMed  PubMed Central  Google Scholar 

Cho M-H, Cho K, Kang H-J, Jeon E-Y, Kim H-S, Kwon H-J, Kim H-M, Kim D-H, Yoon S-Y (2014) Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 10:1761–1775

Article  PubMed  PubMed Central  Google Scholar 

Choi DC, Yoo M, Kabaria S, Junn E (2018) MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy. Neurosci Lett 678:118–123

Article  PubMed  PubMed Central  Google Scholar 

Coune PG, Bensadoun J-C, Aebischer P, Schneider B (2011) Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson’s disease. J Parkinson’s Dis 1:373–387

Article  Google Scholar 

Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A (2013) TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc Natl Acad Sci USA 110:E1817–E1826

Article  ADS  PubMed  PubMed Central  Google Scholar 

Dello Russo C, Lisi L, Feinstein DL, Navarra P (2013) mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis. Glia 61:301–311

Article  Google Scholar 

Diling C, Yinrui G, Longkai Q, Xiaocui T, Yadi L, Xin Y, Guoyan H, Ou S, Tianqiao Y, Dongdong W (2019) Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding dynamin-1 and adaptor protein 2 B1 in AD-like mice. Aging (albany NY) 11:12002

Article  PubMed  Google Scholar 

Ding Y, Luan W, Wang Z, Cao Y (2022) LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer’s disease. Arch Gerontol Geriatr 99:104614

Article  PubMed  Google Scholar 

Dong L, Zheng Y, Gao L, Luo X (2021) lncRNA NEAT1 prompts autophagy and apoptosis in MPTP-induced Parkinson’s disease by impairing miR-374c-5p. Acta Biochim Biophys Sinica. https://doi.org/10.1093/abbs/gmab055

Article  Google Scholar 

Du G, Liu X, Chen X, Song M, Yan Y, Jiao R, Wang C-C (2010) Drosophila histone deacetylase 6 protects dopaminergic neurons against α-synuclein toxicity by promoting inclusion formation. Mol Biol Cell 21:2128–2137

Article  PubMed  PubMed Central  Google Scholar 

Du X, Huo X, Yang Y, Hu Z, Botchway BO, Jiang Y, Fang M (2017) miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice. Toxicol Lett 280:195–205

Article  PubMed  Google Scholar 

Dugger BN, Dickson DW (2017) Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol 9:a028035

Article  PubMed  PubMed Central  Google Scholar 

Duve CD, Wattiaux R (1966) Functions of lysosomes. Ann Rev Physiol 28:435–492

Article  Google Scholar 

Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861–874

Article  PubMed  Google Scholar 

Fan W, Nassiri A, Zhong Q (2011) Autophagosome targeting and membrane curvature sensing by Barkor/Atg14 (L). Proc Natl Acad Sci USA 108:7769–7774

Article  ADS  PubMed  PubMed Central  Google Scholar 

Fan Y, Zhao X, Lu K, Cheng G (2020) LncRNA BDNF-AS promotes autophagy and apoptosis in MPTP-induced Parkinson’s disease via ablating microRNA-125b-5p. Brain Res Bull 157:119–127

Article  PubMed  Google Scholar 

Felekkis K, Touvana E, Stefanou C, Deltas C (2010) microRNAs: a newly described class of encoded molecules that play a role in health and disease. Hippokratia 14:236

PubMed  PubMed Central  Google Scholar 

Feng Y, He D, Yao Z, Klionsky DJ (2014) The machinery of macroautophagy. Cell Res 24:24–41

Article  PubMed  Google Scholar 

Feng Z, Zhang L, Wang S, Hong Q (2020) Circular RNA circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway in Parkinson’s disease. Biochem Biophys Res Commun 522:388–394

Article  PubMed  Google Scholar 

Fernández-de Frutos M, Galán-Chilet I, Goedeke L, Kim B, Pardo-Marqués V, Pérez-García A, Herrero JI, Fernández-Hernando C, Kim J, Ramírez CM (2019) MicroRNA 7 impairs insulin signaling and regulates Aβ levels through posttranscriptional regulation of the insulin receptor substrate 2, insulin receptor, insulin-degrading enzyme, and liver X receptor pathway. Mol Cell Biol 39:e00170-e1119

Article  PubMed  PubMed Central  Google Scholar 

Fragkouli A, Doxakis E (2014) miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway. Front Cell Neurosci 8:182

Article  PubMed  PubMed Central  Google Scholar 

Fujita N, Hayashi-Nishino M, Fukumoto H, Omori H, Yamamoto A, Noda T, Yoshimori T (2008) An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell 19:4651–4659

Article  PubMed  PubMed Central  Google Scholar 

Ge B, Wu H, Shao D, Li S, Li F (2019) Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1. Aging Pathobiol Ther 1:17–24

Article  Google Scholar 

Ge X, Guo M, Hu T, Li W, Huang S, Yin Z, Li Y, Chen F, Zhu L, Kang C (2020) Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI. Mol Ther 28:503–522

Article  PubMed  Google Scholar 

Gong X, Wang H, Ye Y, Shu Y, Deng Y, He X, Lu G, Zhang S (2016) miR-124 regulates cell apoptosis and autophagy in dopaminergic neurons and protects them by regulating AMPK/mTOR pathway in Parkinson’s disease. Am J Transl Res 8:2127

PubMed  PubMed Central  Google Scholar 

Gourvest M, Brousset P, Bousquet M (2019) Long noncoding RNAs in acute myeloid leukemia: functional characterization and clinical relevance. Cancers (basel). https://doi.org/10.1038/cdd.2015.172

Article  PubMed