High dietary salt intake attenuates nitric oxide mediated endothelium-dependent vasodilation and increases oxidative stress in pregnancy

aDepartment of Gynaecology and Obstetrics, University Hospital Centre Osijek

bDepartment of Gynaecology and Obstetrics, Faculty of Medicine Osijek

cDepartment of Physiology and Immunology, Faculty of Medicine Osijek

dScientific Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Correspondence to Ana Stupin, MD, PhD, Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, HR-31 000, Osijek, Croatia. E-mail: [email protected]

Abbreviations: 8-iso-PGF2α, 8-iso-prostaglandin F2 alpha; ACh, acetylcholine; AChID, ACh-induced dilation; AUC, area under the curve; BP, blood pressure; ECW, extracellular water; FFM, fat-free mass; FFQ, food frequency questionnaire; FMD, flow-mediated dilatation; FRAP, ferric reducing ability of plasma assay; GFR, glomerular filtration rate; GWG, gestational weight gain; HDP, hypertensive disorders of pregnancy; HR, heart rate; ICW, intracellular water; LDF, laser Doppler flowmetry; LTH, local thermal hyperemia; MABP, mean arterial blood pressure; MDA, malondialdehyde; N, number of participants; O, vascular occlusion; PORH, post-occlusive reactive hyperemia; ROS, reactive oxygen species; SD, standard deviation; SNP, sodium nitroprusside; SNPID, SNP-induced dilation; TBARS, thiobarbituric acid reactive substances; TBW, total body water; TPTZ, 2,4,6-tris(2-pyridyl)- s-triazine

Received 30 July, 2023

Revised 6 November, 2023

Accepted 6 December, 2023

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