Associations between lipid-lowering drugs and pregnancy and perinatal outcomes: a Mendelian randomization study

Department of Obstetrics and Gynecology, Hebei General Hospital, Hebei, China

Correspondence to Yan Huo, Department of Obstetrics and Gynecology, Hebei General Hospital, Hebei 000050, China. E-mail: [email protected]

Abbreviations: CHD, coronary heart disease; eQTL, expression quantitative trait loci studies; GLGC, Global Lipid Genetics Consortium; GWAS, genome-wide association studies; HMGCR, hydroxymethylglutaryl-coenzyme reductase; IVW, inverse variance weighting; LDL-C, low-density lipoprotein cholesterol; MAF, minimal allele frequency; NPC1L1i, Niemann–Pick C1- Like 1; PCSK9, proprotein convertase subtilisin/kexin type 9; SMR, summary data-based Mendelian randomization; SNP, single nucleotide polymorphism; UKB, UK Biobank

Received 14 October, 2023

Revised 24 November, 2023

Accepted 4 January, 2024

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