From the Division of Thoracic Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA (P.E.T., N.D.M., I.T., A.-S.W.D., W.A., A.G., F.J.F.); Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany (P.E.T.); Department of Medicine (D.P.K.), Harvard Medical School, Boston, MA (M.L.B., N.D.M., E.J.S., D.P.K., F.J.F.); Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA (B.A., M.L.B.); Department of Orthopedic Surgery, Harvard Medical School, Boston, MA (M.L.B.); Endocrine Division, Massachusetts General Hospital, Boston, MA (M.L.B.); Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA (E.J.S., D.P.K.); and Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.J.S., D.P.K.).

Received for publication May 17, 2023; and accepted for publication, after revision, June 27, 2023.

Conflicts of interest and sources of funding: D.P.K. serves on scientific advisory boards for Reneo, Solarea Bio, and Pfizer, serves on a data monitoring committee for Agnovos, and receives royalties for publication from Wolters Kluwer for UpToDate. F.J.F. receives salary support from the William M. Wood Foundation for unrelated research, consulting fees from Pfizer, and has a related patent. The other authors have no relevant disclosures. The Framingham Heart Study is supported by contract no. HHSN268201500001I from the National Heart, Lung, and Blood Institute (NHLBI) with additional support from other sources. This work was supported by the FHS Core Contract (NHLBI award no. 75N92019D00031) and National Institutes of Health grants R01-AR073019 (M.L.B.), R01 AG041658 (E.J.S.), and R01 AR041398 (D.P.K.) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. This manuscript was not prepared in collaboration with investigators of the Framingham Heart Study and does not necessarily reflect the opinions or conclusions of the Framingham Heart Study or the NHLBI.

Correspondence to: Florian J. Fintelmann, MD, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114. E-mail: [email protected].

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