Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Roarty K, Echeverria GV. Laboratory models for investigating breast cancer therapy resistance and metastasis. Front Oncol. 2021;11:645698.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Westphal T, Gampenrieder SP, Rinnerthaler G, Greil R. Cure in metastatic breast cancer. Memo. 2018;11(3):172–9.

Article  PubMed  PubMed Central  Google Scholar 

Scimeca M, Trivigno D, Bonfiglio R, Ciuffa S, Urbano N, Schillaci O, Bonanno E. Breast cancer metastasis to bone: From epithelial to mesenchymal transition to breast osteoblast-like cells. In: Seminars in cancer biology. 2021. Elsevier.

Riggio AI, Varley KE, Welm AL. The lingering mysteries of metastatic recurrence in breast cancer. Br J Cancer. 2021;124(1):13–26.

Article  PubMed  Google Scholar 

Xiong Z, Deng G, Huang X, Li X, Xie X, Wang J, Shuang Z, Wang X. Bone metastasis pattern in initial metastatic breast cancer: a population-based study. Cancer Manag Res. 2018;10:287–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marazzi F, Orlandi A, Manfrida S, Masiello V, Di Leone A, Massaccesi M, Moschella F, Franceschini G, Bria E, Gambacorta MA. Diagnosis and treatment of bone metastases in breast cancer: radiotherapy, local approach and systemic therapy in a guide for clinicians. Cancers. 2020;12(9):2390.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weidle UH, Birzele F, Kollmorgen G, Ruger R. Molecular mechanisms of bone metastasis. Cancer Genom Proteom. 2016;13(1):1–12.

CAS  Google Scholar 

Rossi L, Longhitano C, Kola F, Del Grande M. State of art and advances on the treatment of bone metastases from breast cancer: a concise review. Chin Clin Oncolrnal. 2020;9(2):18.

Article  Google Scholar 

Salamanna F, Contartese D, Maglio M, Fini M. A systematic review on in vitro 3D bone metastases models: a new horizon to recapitulate the native clinical scenario? Oncotargetrnal. 2016;7(28):44803–20.

Article  Google Scholar 

Jiang ZR, Yang LH, Jin LZ, Yi LM, Bing PP, Zhou J, Yang JS. Identification of novel cuproptosis-related lncRNA signatures to predict the prognosis and immune microenvironment of breast cancer patients. Front Oncol. 2022;12:988680.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang B-X, Li K.-P, Yu T, Feng H-Y. Rosuvastatin promotes osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by the Wnt/β-catenin signal. Eur Rev Med Pharmacol Sci 2019;23(22),10161–8.

Jeong H, Jeong JH, Kim JE, Ahn JH, Jung KH, Koh SJ, Cheon J, Sohn J, Kim GM, Lee KS, Sim SH, Park IH, Kim SB. Final results of the randomized phase 2 LEO trial and bone protective effects of everolimus for premenopausal hormone receptor-positive, HER2-negative metastatic breast cancer. Int J Cancerrnal. 2021;149(4):917–24.

Article  CAS  Google Scholar 

D’Oronzo S, Wood S, Brown JE. The use of bisphosphonates to treat skeletal complications in solid tumours. Bone. 2021;147:115907.

Article  CAS  PubMed  Google Scholar 

Nardin S, Mora E, Varughese FM, D’Avanzo F, Vachanaram AR, Rossi V, Saggia C, Rubinelli S, Gennari A. Breast cancer survivorship, quality of life, and late toxicities. Front Oncol. 2020;10(864):864.

Article  PubMed  PubMed Central  Google Scholar 

Wang C-Y, Hong P-D, Wang D-H, Cherng J-H, Chang S-J, Liu C-C, Fang T-J, Wang Y-W. Polymeric gelatin scaffolds affect mesenchymal stem cell differentiation and its diverse applications in tissue engineering. Int Mol Sci. 2020;21(22):8632.

Article  CAS  Google Scholar 

Rani A, Stebbing J, Giamas G, Murphy J. Endocrine resistance in hormone receptor positive breast cancer-from mechanism to therapy. Front Endocrinol (Lausanne). 2019;10(245):245.

Article  PubMed  Google Scholar 

Fusco N, Malapelle U, Fassan M, Marchio C, Buglioni S, Zupo S, Criscitiello C, Vigneri P, Dei Tos AP, Maiorano E, Viale G. PIK3CA mutations as a molecular target for hormone receptor-positive, HER2-negative metastatic breast cancer. Front Oncol. 2021;11(562):644737.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coleman RE, Brown J, Holen I. Bone metastases. Abeloff's Clin Oncol 2020:809–830. e3. https://doi.org/10.1016/B978-0-323-47674-4.00056-6.

Ban J, Fock V, Aryee DN, Kovar H. Mechanisms, diagnosis and treatment of bone metastases. Cells. 2021;10(11):2944.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riehl BD, Kim E, Bouzid T, Lim JY. The role of microenvironmental cues and mechanical loading milieus in breast cancer cell progression and metastasis. Front Bioeng Biotechnol. 2021;8:608526.

Article  PubMed  PubMed Central  Google Scholar 

Ma X, Yu J. Role of the bone microenvironment in bone metastasis of malignant tumors-therapeutic implications. Cellular Oncologyrnal. 2020;43:751–61.

Article  Google Scholar 

Hofbauer LC, Bozec A, Rauner M, Jakob F, Perner S, Pantel K. Novel approaches to target the microenvironment of bone metastasis. Nat Rev Clin Oncol. 2021;18(8):488–505.

Article  PubMed  Google Scholar 

Ottewell PD, Lawson MA. Advances in murine models of breast cancer bone disease. J Cancer Metastasis Treat. 2021;7:11. https://doi.org/10.20517/2394-4722.2021.14.

Cox TR. The matrix in cancer. J Nat Rev Cancer 2021;21:217–38. https://doi.org/10.1038/s41568-020-00329-7.

Hussain Z, Mehmood S, Liu X, Liu Y, Wang G, Pei R. Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering. J Eng Regener 2023;5(1):21–44. https://doi.org/10.1016/j.engreg.2023.10.003.

Zhang J, Shen Q, Ma Y, Liu L, Jia W, Chen L, Xie J. Calcium homeostasis in Parkinson’s disease: from pathology to treatment. J Neurosci Bull. 2022;38(10):1267–70.

Article  CAS  Google Scholar 

Tertuliano OA, Greer JR. The nanocomposite nature of bone drives its strength and damage resistance. J Nature Mater. 2016;15(11):1195–202.

Article  ADS  CAS  Google Scholar 

Nudelman F, Pieterse K, George A, Bomans PH, Friedrich H, Brylka LJ, Hilbers PA, de With G, Sommerdijk NA. The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors. J Nat Mater. 2010;9(12):1004–9.

Article  ADS  CAS  Google Scholar 

Manduca P, Castagnino A, Lombardini D, Marchisio S, Soldano S, Ulivi V, Zanotti S, Garbi C, Ferrari N, Palmieri D. Role of MT1-MMP in the osteogenic differentiation. J Bone. 2009;44(2):251–65.

Article  CAS  Google Scholar 

Buxton P, Bitar M, Gellynck K, Parkar M, Brown R, Young A, Knowles J, Nazhat S. Dense collagen matrix accelerates osteogenic differentiation and rescues the apoptotic response to MMP inhibition. J Bone. 2008;43(2):377–85.

Article  CAS  PubMed  Google Scholar 

Ganss B, Kim RH, Sodek J. Bone sialoprotein. J Crit Rev Oral Biol Med. 1999;10(1):79–98.

Article  CAS  Google Scholar 

Bi Y, Stuelten CH, Kilts T, Wadhwa S, Iozzo RV, Robey PG, Chen X-D, Young MF. Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem. 2005;280(34):30481–9.

Article  CAS  PubMed  Google Scholar 

Knapinska AM, Singh C, Drotleff G, Blanco D, Chai C, Schwab J, Herd A, Fields GB. Matrix metalloproteinase 13 inhibitors for modulation of osteoclastogenesis: enhancement of solubility and stability. J Chem Med Chem. 2021;16(7):1133–42.

Article  CAS  Google Scholar 

Zhang J-H, Tang J, Wang J, Ma W, Zheng W, Yoneda T, Chen J. Over-expression of bone sialoprotein enhances bone metastasis of human breast cancer cells in a mouse model. Int J Oncol. 2003;23(4):1043–8.

CAS  PubMed  Google Scholar 

Ibrahim T, Leong I, Sanchez-Sweatman O, Khokha R, Sodek J, Tenenbaum HC, Ganss B, Cheifetz S. Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. J Clin Exper Metastasis. 2000;18(3):253–60.

Article  CAS  Google Scholar 

Rustamov V, Keller F, Klicks J, Hafner M, Rudolf R. Bone sialoprotein shows enhanced expression in early, high-proliferation stages of three-dimensional spheroid cell cultures of breast cancer cell line MDA-MB-231. Front Oncol. 2019;9:36.

Article  PubMed  PubMed Central  Google Scholar 

Von Euw S, Wang Y, Laurent G, Drouet C, Babonneau F, Nassif N, Azais T. Bone mineral: new insights into its chemical composition. Sci Rep. 2019;9(1):1–11.

Google Scholar 

Tang S, Zeenath U, Vashishth D. Effects of non-enzymatic glycation on cancellous bone fragility. J Bone. 2007;40(4):1144–51.

Article  CAS  Google Scholar 

Helfrich M, Nesbitt S, Lakkakorpi P, Barnes M, Bodary S, Shankar G, Mason W, Mendrick D, Väänänen H, Horton M. β1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. J Bone. 1996;19(4):317–28.

Article  CAS  Google Scholar 

Helfrich MH, Nesbitt SA, Dorey EL, Horton MA. Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a β3 integrin. J Bone Mineral Res. 1992;7(3):335–43.

Article  CAS  Google Scholar 

Litzenberger JB, Kim J-B, Tummala P, Jacobs CR. β 1 integrins mediate mechanosensitive signaling pathways in osteocytes. J Calcified Tissue Int. 2010;86(4):325–32.

Article  CAS  Google Scholar 

McNamara L, Majeska R, Weinbaum S, Friedrich V, Schaffler MB. Attachment of osteocyte cell processes to the bone matrix. J Anatom Record: Adv Integr Anatom Evol Biol: Advances. 2009;292(3):355–63.

Article  CAS