Kany S, Vollrath JT, Relja B. Cytokines in inflammatory disease. Int J Mol Sci. 2019;20(23):6008. https://doi.org/10.3390/ijms20236008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geginat J, Sallusto F, Lanzavecchia A. Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells. J Exp Med. 2001;194(12):1711–9. https://doi.org/10.1084/jem.194.12.1711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Størling J, et al. Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells. Diabetes. 2009;58(8):1807–15. https://doi.org/10.2337/db08-0178.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G. Neuroinflammation pathways: a general review. Int J Neurosci. 2017;127(7):624–33. https://doi.org/10.1080/00207454.2016.1212854.

Article  CAS  PubMed  Google Scholar 

Schetters STT, Gomez-Nicola D, Garcia-Vallejo JJ, Van Kooyk Y. Neuroinflammation: microglia and T cells get ready to tango. Front Immunol. 2018;25(8):1905. https://doi.org/10.3389/fimmu.2017.01905.

Article  CAS  Google Scholar 

Clark DN, Begg LR, Filiano AJ. Unique aspects of IFN-γ/STAT1 signaling in neurons. Immunol Rev. 2022;311(1):187–204. https://doi.org/10.1111/imr.13092.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guillery RW. Observations of synaptic structures: origins of the neuron doctrine and its current status. Philos Trans R Soc Lond B Biol Sci. 2005;360:1281–307.

Article  CAS  PubMed  Google Scholar 

Yuste R. From the neuron doctrine to neural networks. Nat Rev Neurosci. 2015;16:487–97.

Article  CAS  PubMed  Google Scholar 

Denk W, Briggman K, Helmstaedter M. Structural neurobiology: missing link to a mechanistic understanding of neural computation”. Nat Rev Neurosci. 2012;13:351–8.

Article  CAS  PubMed  Google Scholar 

Hof PR, Kidd G, DeFelipe J, de Vellis J, Gama Sosa MA, Elder GA, et al. Cellular components of nervous tissue. In: Byrne JH, Heidelberger R, Waxham MN, editors., et al., From molecules to networks: an introduction to cellular and molecular neuroscience. 3rd ed. Cambridge: Academic Press; 2014. p. 3–21. https://doi.org/10.1016/B978-0-12-397179-1.00001-4.

Chapter  Google Scholar 

Bernaus A, Blanco S, Sevilla A. Glia crosstalk in neuroinflammatory diseases. Front Cell Neurosci. 2020;29(14):209.

Article  Google Scholar 

Carson MJ, Doose JM, Melchior B, Schmid CD, Ploix CC. CNS immune privilege: hiding in plain sight. Immunol Rev. 2006;213:48–65. https://doi.org/10.1111/j.1600-065X.2006.00441.x.

Article  PubMed  PubMed Central  Google Scholar 

Marin I, Kipnis J. Learning and memory … and the immune system. Learn Mem. 2013;20:601–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shechter R, London A, Schwartz M. Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates. Nat Rev Immunol. 2013;13:206–18.

Article  CAS  PubMed  Google Scholar 

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015;212(7):991–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tracey K. Reflex control of immunity. Nat Rev Immunol. 2009;9:418–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev. 2018;98:477–504.

Article  CAS  PubMed  Google Scholar 

Sawada M, Suzumura A, Marunouchi T. Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells. Int J Dev Neurosci. 1995;13:253–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heinisch S, Kirby LG. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology. 2010;58(2):501–14.

Article  CAS  PubMed  Google Scholar 

Louveau A, Harris TH, Kipnis J. Revisiting the mechanisms of CNS immune privilege. Trends Immunol. 2015;36:569–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McAfoose J, Baune BT. Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev. 2009;33(3):355–66.

Article  CAS  PubMed  Google Scholar 

Nisticò R, Salter E, Nicolas C, Feligioni M, Mango D, Bortolotto ZA, Gressens P, Collingridge GL, Peineau S. Synaptoimmunology—roles in health and disease. Mol Brain. 2017;10(1):26.

Article  PubMed  PubMed Central  Google Scholar 

Depino AM, Alonso M, Ferrari C, del Rey A, Anthony D, Besedovsky H, Medina JH, Pitossi F. Learning modulation by endogenous hippocampal IL-1: blockade of endogenous IL-1 facilitates memory formation. Hippocampus. 2004;14(4):526–35. https://doi.org/10.1002/hipo.10164.

Article  CAS  PubMed  Google Scholar 

Stellwagen D, Malenka R. Synaptic scaling mediated by glial TNF-α. Nature. 2006;440:1054–9.

Article  CAS  PubMed  Google Scholar 

Santello M, Volterra A. TNFα in synaptic function: switching gears. Trends Neurosci. 2012;35(10):638–47.

Article  CAS  PubMed  Google Scholar 

Vezzani A, Viviani B. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability. Neuropharmacology. 2015;96:70–82.

Article  CAS  PubMed  Google Scholar 

Falcicchia C, Tozzi F, Arancio O, Watterson DM, Origlia N. Involvement of p38 MAPK in synaptic function and dysfunction. Int J Mol Sci. 2020;21(16):5624.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bodnar CN, Morganti JM, Bachstetter AD. Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism. Neural Regen Res. 2018;13(10):1693–704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Cheng Q, Malik S, Yang J. Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons. J Pharmacol Exp Ther. 2000;292(2):497–504.

CAS  PubMed  Google Scholar 

Pribiag H, Stellwagen D. TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. J Neurosci. 2013;33(40):15879–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giacco V, Panattoni G, Medelin M, Bonechi E, Aldinucci A, Ballerini C, et al. Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures. J Neuroinflammation. 2019;16(1):127. https://doi.org/10.1186/s12974-019-1519-z.

Article  PubMed  PubMed Central  Google Scholar 

Ren S, Breuillaud L, Yao W, Yin T, Norris KA, Zehntner SP, D’Adamio L. TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer’s disease pathology in young Trem2R47H rats. J Biol Chem. 2021;296:100089.

Article  CAS  PubMed  Google Scholar 

Stellwagen D, Beattie EC, Seo JY, Malenka RC. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci. 2005;25(12):3219–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Den Bosch L, Van Damme P, Bogaert E, Robberecht W. The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta. 2006;1762(11–12):1068–82.

Article  PubMed  Google Scholar 

Schäfers M, Sorkin L. Effect of cytokines on neuronal excitability. Neurosci Lett. 2008;437(3):188–93.

Article  PubMed  Google Scholar 

Sitcheran R, Gupta P, Fisher PB, Baldwin AS. Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression. EMBO J. 2005;24(3):510–20.