Steeg, P. S. Targeting metastasis. Nat. Rev. Cancer 16, 201–218 (2016).
Article CAS PubMed PubMed Central Google Scholar
Wirtz, D., Konstantopoulos, K. & Searson, P. C. The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat. Rev. Cancer 11, 512–522 (2011).
Article CAS PubMed PubMed Central Google Scholar
Gensbittel, V. et al. Mechanical adaptability of tumor cells in metastasis. Dev. Cell 56, 164–179 (2021).
Article CAS PubMed Google Scholar
Nia, H. T., Munn, L. L. & Jain, R. K. Physical traits of cancer. Science 370, eaaz0868 (2020).
Article CAS PubMed PubMed Central Google Scholar
Balestrini, J. L., Chaudhry, S., Sarrazy, V., Koehler, A. & Hinz, B. The mechanical memory of lung myofibroblasts. Integr. Biol. 4, 410–421 (2012).
Yang, C., Tibbitt, M. W., Basta, L. & Anseth, K. S. Mechanical memory and dosing influence stem cell fate. Nat. Mater. 13, 645–652 (2014).
Article CAS PubMed PubMed Central Google Scholar
Lee, J., Abdeen, A. A. & Kilian, K. A. Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment. Sci. Rep. 4, 5188 (2014).
Article CAS PubMed PubMed Central Google Scholar
Heo, S. J. et al. Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells. Sci. Rep. 5, 16895 (2015).
Article CAS PubMed PubMed Central Google Scholar
Frank, V. et al. Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency. Sci. Rep. 6, 24264 (2016).
Article CAS PubMed PubMed Central Google Scholar
Li, C. X. et al. MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells. Nat. Mater. 16, 379–389 (2017).
Article CAS PubMed Google Scholar
Killaars, A. R. et al. Extended exposure to stiff microenvironments leads to persistent chromatin remodeling in human mesenchymal stem cells. Adv. Sci. 6, 1801483 (2019).
Dunham, C., Havlioglu, N., Chamberlain, A., Lake, S. & Meyer, G. Adipose stem cells exhibit mechanical memory and reduce fibrotic contracture in a rat elbow injury model. FASEB J. 34, 12976–12990 (2020).
Article CAS PubMed Google Scholar
Nasrollahi, S. et al. Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory. Biomaterials 146, 146–155 (2017).
Article CAS PubMed PubMed Central Google Scholar
Hammer, A. M. et al. Stromal PDGFR-α activation enhances matrix stiffness, impedes mammary ductal development, and accelerates tumor growth. Neoplasia 19, 496–508 (2017).
Article CAS PubMed PubMed Central Google Scholar
Schrader, J. et al. Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology 53, 1192–1205 (2011).
Article CAS PubMed Google Scholar
Ulrich, T. A., de Juan Pardo, E. M. & Kumar, S. The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Res. 69, 4167–4174 (2009).
Article CAS PubMed PubMed Central Google Scholar
Nguyen, T. V., Sleiman, M., Moriarty, T., Herrick, W. G. & Peyton, S. R. Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening. Biomaterials 35, 5749–5759 (2014).
Article CAS PubMed Google Scholar
Rice, A. J. et al. Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells. Oncogenesis 6, e352 (2017).
Article CAS PubMed PubMed Central Google Scholar
Haage, A. & Schneider, I. C. Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells. FASEB J. 28, 3589–3599 (2014).
Article CAS PubMed Google Scholar
Nukuda, A. et al. Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression. Oncogenesis 4, e165 (2015).
Article CAS PubMed PubMed Central Google Scholar
Wu, S. et al. Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation. J. Exp. Clin. Cancer Res. 37, 99 (2018).
Article PubMed PubMed Central Google Scholar
Li, M. et al. Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma. Cancer Commun. 42, 1162–1184 (2022).
Taufalele, P. V. et al. Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment. Acta Biomater. 163, 365–377 (2022).
Kraning-Rush, C. M., Califano, J. P. & Reinhart-King, C. A. Cellular traction stresses increase with increasing metastatic potential. PLoS ONE 7, e32572 (2012).
Article CAS PubMed PubMed Central Google Scholar
Grasset, E. M. et al. Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells. Cancer Res. 78, 5229–5242 (2018).
Article CAS PubMed Google Scholar
Tian, F. et al. Mechanical responses of breast cancer cells to substrates of varying stiffness revealed by single-cell measurements. J. Phys. Chem. Lett. 11, 7643–7649 (2020).
Article CAS PubMed Google Scholar
Molter, C. W. et al. Prostate cancer cells of increasing metastatic potential exhibit diverse contractile forces, cell stiffness, and motility in a microenvironment stiffness-dependent manner. Front. Cell Dev. Biol. 10, 932510 (2022).
Article PubMed PubMed Central Google Scholar
Baker, E. L., Lu, J., Yu, D., Bonnecaze, R. T. & Zaman, M. H. Cancer cell stiffness: integrated roles of three-dimensional matrix stiffness and transforming potential. Biophys. J. 99, 2048–2057 (2010).
Article CAS PubMed PubMed Central Google Scholar
Rianna, C. & Radmacher, M. Influence of microenvironment topography and stiffness on the mechanics and motility of normal and cancer renal cells. Nanoscale 9, 11222–11230 (2017).
Article CAS PubMed Google Scholar
Wullkopf, L. et al. Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential. Mol. Biol. Cell 29, 2378–2385 (2018).
Article CAS PubMed PubMed Central Google Scholar
Pathak, A. & Kumar, S. Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc. Natl Acad. Sci. USA 109, 10334–10339 (2012).
Article CAS PubMed PubMed Central Google Scholar
Pogoda, K. et al. Soft substrates containing hyaluronan mimic the effects of increased stiffness on morphology, motility, and proliferation of glioma cells. Biomacromolecules 18, 3040–3051 (2017).
Article CAS PubMed PubMed Central Google Scholar
Matte, B. F. et al. Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma. J. Cell Sci. 132, jcs224360 (2019).
PubMed PubMed Central Google Scholar
Acerbi, I. et al. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr. Biol. 7, 1120–1134 (2015).
Sinkus, R. et al. MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography. Magn. Reson. Med. 58, 1135–1144 (2007).
Evans, A. et al. Differentiating benign from malignant solid breast masses: value of shear wave elastography according to lesion stiffness combined with greyscale ultrasound according to BI-RADS classification. Br. J. Cancer 107, 224–229 (2012).
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