A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)
推出的年份: 1993
副标题
树号: C01.207.800, C10.228.228.800, C10.574.843
MeSH 单一 ID: D017096
进入的组:
Dementias, Transmissible
Dementia, Transmissible
Transmissible Dementia
Transmissible Dementias
Encephalopathies, Spongiform, Transmissible
Prion-Induced Disorders
Prion-Induced Disorder
Disorder, Prion-Induced
Disorders, Prion-Induced
Prion Induced Disorder
Transmissible Spongiform Encephalopathies
Prion Disease
Prion-Associated Disorders
Spongiform Encephalopathies, Transmissible
Encephalopathies, Transmissible Spongiform
Encephalopathy, Transmissible Spongiform
Spongiform Encephalopathy, Transmissible
Transmissible Spongiform Encephalopathy
Prion Protein Diseases
Prion Protein Disease
Human Transmissible Spongiform Encephalopathies, Inherited
Inherited Human Transmissible Spongiform Encephalopathies
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